Entity Central Index Key
Lessee operating lease liability payments due after year three.
Cover [Abstract]
Document Type
Document Type
Amendment Flag
Amendment Flag
Document Period End Date
Document Period End Date
Document Fiscal Year Focus
Document Fiscal Year Focus
Document Fiscal Period Focus
Document Fiscal Period Focus
Trading Symbol
Trading Symbol
Entity Registrant Name
Entity Registrant Name
Entity Central Index Key
Current Fiscal Year End Date
Current Fiscal Year End Date
Entity Filer Category
Entity Filer Category
Entity Small Business
Entity Small Business
Entity Emerging Growth Company
Entity Emerging Growth Company
Title of 12(b) Security
Security12b Title
Entity Common Stock, Shares Outstanding
Entity Common Stock Shares Outstanding
Entity Current Reporting Status
Entity Current Reporting Status
Entity Shell Company
Entity Shell Company
Entity File Number
Entity File Number
Entity Tax Identification Number
Entity Tax Identification Number
Entity Address, Address Line One
Entity Address Address Line1
Entity Address, Address Line Two
Entity Address Address Line2
Entity Address, Address Line Three
Entity Address Address Line3
Entity Address, City or Town
Entity Address City Or Town
Entity Address, State or Province
Entity Address State Or Province
Entity Address, Postal Zip Code
Entity Address Postal Zip Code
City Area Code
City Area Code
Local Phone Number
Local Phone Number
Entity Interactive Data Current
Entity Interactive Data Current
Entity Incorporation, State or Country Code
Entity Incorporation State Country Code
Document Annual Report
Document Annual Report
Document Transition Report
Document Transition Report
Security Exchange Name
Security Exchange Name
Entity Voluntary Filers
Entity Voluntary Filers
Entity Well-known Seasoned Issuer
Entity Well Known Seasoned Issuer
ICFR Auditor Attestation Flag
Icfr Auditor Attestation Flag
Entity Public Float
Entity Public Float
Auditor Name
Auditor Name
Auditor Location
Auditor Location
Auditor Firm ID
Auditor Firm Id
Statement Of Financial Position [Abstract]
ASSETS
Assets [Abstract]
Current assets:
Assets Current [Abstract]
Cash and cash equivalents
Cash And Cash Equivalents At Carrying Value
Restricted cash
Restricted Cash
Short-term investments
Short Term Investments
Prepaid expenses and other current assets
Prepaid Expense And Other Assets Current
Total current assets
Assets Current
Property and equipment, net
Property Plant And Equipment Net
Right-of-use asset
Operating Lease Right Of Use Asset
Other assets
Other Assets Noncurrent
Total assets
Assets
LIABILITIES AND STOCKHOLDERS' EQUITY
Liabilities And Stockholders Equity [Abstract]
Current liabilities:
Liabilities Current [Abstract]
Accounts payable
Accounts Payable Current
Accrued expenses and other current liabilities
Accrued Liabilities And Other Liabilities
Current portion of deferred revenue
Contract With Customer Liability Current
Current portion of right-of-use liability
Operating Lease Liability Current
Current portion of term loan
Loans Payable Current
Derivative liability
Derivative Liabilities Current
Total current liabilities
Liabilities Current
Long-term liabilities:
Liabilities Noncurrent [Abstract]
Deferred revenue, less current portion
Contract With Customer Liability Noncurrent
Right-of-use liability, less current portion
Operating Lease Liability Noncurrent
Term loan, less current portion
Long Term Loans Payable
Other long-term liabilities
Other Liabilities Noncurrent
Total long-term liabilities
Liabilities Noncurrent
Total liabilities
Liabilities
Commitments, contingencies and guarantees (Note 16)
Commitments And Contingencies
Stockholders' equity:
Stockholders Equity [Abstract]
Preferred stock, $0.001 par value, 10,000,000 shares authorized; 0 shares outstanding at December 31, 2021 and December 31, 2020, respectively
Preferred Stock Value
Common stock, $0.0001 par value, 100,000,000 shares authorized; 54,983,105 and 47,881,223 shares outstanding at December 31, 2021 and December 31, 2020, respectively
Common Stock Value
Additional paid-in capital
Additional Paid In Capital Common Stock
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income Loss Available For Sale Securities Adjustment Net Of Tax
Accumulated deficit
Retained Earnings Accumulated Deficit
Total stockholders' equity
Stockholders Equity
Total liabilities and stockholders' equity
Liabilities And Stockholders Equity
Preferred stock, par value
Preferred Stock Par Or Stated Value Per Share
Preferred stock, shares authorized
Preferred Stock Shares Authorized
Preferred stock, shares outstanding
Preferred Stock Shares Outstanding
Common stock, par value
Common Stock Par Or Stated Value Per Share
Common stock, shares authorized
Common Stock Shares Authorized
Common stock, shares outstanding
Common Stock Shares Outstanding
Income Statement [Abstract]
Revenues:
Revenues [Abstract]
Total revenues
Revenue From Contract With Customer Excluding Assessed Tax
Type of revenue [extensible list]
Type Of Revenue Extensible List
Operating expenses:
Operating Expenses [Abstract]
Research and development
Research And Development Expense
General and administrative
General And Administrative Expense
Total operating expenses
Operating Expenses
Income (loss) from operations
Operating Income Loss
Other (expense) income:
Nonoperating Income Expense [Abstract]
Interest expense
Interest Expense
Interest income
Investment Income Interest
Other (expense) income:
Other Nonoperating Income Expense
Total other (expense) income
Nonoperating Income Expense
Net income (loss)
Net Income Loss
Net income (loss) attributable to common stockholders
Net Income Loss Available To Common Stockholders Basic
Net income (loss) Per Share:
Earnings Per Share [Abstract]
Basic earnings (loss) per share attributable to common stockholders
Earnings Per Share Basic
Diluted earnings (loss) per share attributable to common stockholders
Earnings Per Share Diluted
Weighted-average common shares used in calculating:
Weighted Average Number Of Shares Outstanding [Abstract]
Basic earnings (loss) per share attributable to common stockholders
Weighted Average Number Of Shares Outstanding Basic
Diluted earnings (loss) per share attributable to common stockholders
Weighted Average Number Of Diluted Shares Outstanding
Statement Of Income And Comprehensive Income [Abstract]
Net income (loss)
Other comprehensive gain (loss):
Other Comprehensive Income Loss Net Of Tax Period Increase Decrease [Abstract]
Unrealized gains (losses) on marketable securities, net of tax
Other Comprehensive Income Unrealized Holding Gain Loss On Securities Arising During Period Net Of Tax
Comprehensive income (loss)
Comprehensive Income Net Of Tax
Stock issued during period shares at the market offering net.
Stock issued during period value at the market offering net.
Stock issued during period value direct offering.
Stock issued during period value direct offering.
Stock issued during period shares pre funded common stock warrants from direct offering.
Stock issued during period value pre-funded common stock warrants from direct offering.
Stock issued during period value common stock warrant with direct offering.
Adjustments to additional paid in capital deemed dividend from repricing warrants.
Adjustments to additional paid in capital repricing warrants.
Stock issued during period shares exercise of warrants.
Statement Of Stockholders Equity [Abstract]
Statement [Table]
Statement [Table]
Equity Components
Statement Equity Components [Axis]
Equity Component
Equity Component [Domain]
Common Stock [Member]
Common Stock [Member]
Additional Paid-In Capital [Member]
Additional Paid In Capital [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Accumulated Other Comprehensive Income [Member]
Accumulated Deficit [Member]
Retained Earnings [Member]
Collaborative Arrangement and Arrangement Other than Collaborative
Type Of Arrangement [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Arrangements And Nonarrangement Transactions [Member]
Collaboration and license agreement.
Incyte Share Purchase Agreement [Member]
Collaboration And License Agreement [Member]
Sale of Stock
Subsidiary Sale Of Stock [Axis]
Sale of Stock
Sale Of Stock Name Of Transaction [Domain]
Direct placement offering.
Direct Placement Offering [Member]
Direct Placement Offering [Member]
Follow-on public offering one.
Follow-on Public Offering One [Member]
Follow On Public Offering One [Member]
Follow-on public offering two.
Follow-on Public Offering Two [Member]
Follow On Public Offering Two [Member]
Statement [Line Items]
Statement [Line Items]
Beginning balance
Beginning balance, Shares
Shares Outstanding
Proceeds from "At-the-market" offering, net, Value
Stock Issued During Period Value At The Market Offering Net
Proceeds from "At-the-market" offering, net, Shares
Stock Issued During Period Shares At The Market Offering Net
Proceeds from direct offering, net, value
Stock Issued During Period Value Direct Offering
Proceeds from direct offering,net, Shares
Stock Issued During Period Shares Direct Offering
Proceeds from pre-funded common stock warrant from direct offering, net, value
Stock Issued During Period Value Pre Funded Common Stock Warrants From Direct Offering
Proceeds from pre-funded common stock warrant from direct offering, net, Shares
Stock Issued During Period Shares Pre Funded Common Stock Warrants From Direct Offering
Issuance of common stock warrant with direct offering, value
Stock Issued During Period Value Common Stock Warrant With Direct Offering
Deemed dividend from repricing Series 1 and 2 warrants
Adjustments To Additional Paid In Capital Deemed Dividend From Repricing Warrants
Repricing Series 1 and 2 warrants
Adjustments To Additional Paid In Capital Repricing Warrants
Stock purchase under ESPP
Stock Issued During Period Value Employee Stock Purchase Plan
Stock purchase under ESPP, Shares
Stock Issued During Period Shares Employee Stock Purchase Plans
Proceeds from Incyte Share Purchase Agreement
Stock Issued During Period Value New Issues
Proceeds from Incyte Share Purchase Agreement, Shares
Stock Issued During Period Shares New Issues
Stock-based compensation expense
Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value
Unrealized gains (losses) on short-term investments
Exercise of Series 1 and Series 2 warrants, Shares
Stock Issued During Period Shares Exercise Of Warrants
Vesting of RSU,Shares
Stock Issued During Period Shares Restricted Stock Award Gross
Employee withholdings ESPP
Adjustment To Additional Paid In Capital Income Tax Effect From Share Based Compensation Net
Proceeds from exercise of stock options
Stock Issued During Period Value Stock Options Exercised
Proceeds from exercise of stock options, Shares
Stock Issued During Period Shares Stock Options Exercised
Ending balance
Ending balance, Shares
Stock issued during period value at the market offering expenses.
Stock issued during period value direct offering common stock warrant.
Stock issued during period value offering expenses.
Stock issued during period value pre funded common stock warrant.
Stock issued during period value pre-funded common stock warrant offering expenses.
At-the-market, offering expenses
Stock Issued During Period Value At The Market Offering Expenses
Direct offering, common stock warrants
Stock Issued During Period Value Direct Offering Common Stock Warrant
Direct offering, offering expenses
Stock Issued During Period Value Offering Expenses
Pre-funded common stock warrants
Stock Issued During Period Value Pre Funded Common Stock Warrant
Pre-funded common stock warrants offering expenses
Stock Issued During Period Value Pre Funded Common Stock Warrant Offering Expenses
Depreciation and related adjustment.
Non-cash operating lease expense.
Paid in kind interest and interest reversal.
Statement Of Cash Flows [Abstract]
Follow on public offerings.
Follow-on Public Offerings [Member]
Follow On Public Offerings [Member]
At the market stock offering.
At-the-Market Offering [Member]
At The Market Stock Offering [Member]
Derivative liability.
Derivative Liability [Member]
Derivative Liability [Member]
Private Placement [Member]
Private Placement [Member]
Incyte share purchase agreement.
Incyte Share Purchase Agreement [Member]
Incyte Share Purchase Agreement [Member]
CASH FLOWS FROM OPERATING ACTIVITIES:
Net Cash Provided By Used In Operating Activities [Abstract]
Net income (loss)
Profit Loss
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:
Adjustments To Reconcile Net Income Loss To Cash Provided By Used In Operating Activities [Abstract]
Depreciation
Depreciation And Related Adjustment
Amortization and accretion of investments
Accretion Amortization Of Discounts And Premiums Investments
Non-cash operating lease expense
Noncash Operating Lease Expense
Non-cash interest expense
Paid In Kind Interest And Interest Reversal
Changes in fair value of derivate liability
Derivative Gain Loss On Derivative Net
Stock-based compensation
Share Based Compensation
Other
Other Noncash Income Expense
Changes in operating assets and liabilities:
Increase Decrease In Operating Capital [Abstract]
Prepaid expenses and other assets
Increase Decrease In Prepaid Deferred Expense And Other Assets
Accounts payable
Increase Decrease In Accounts Payable
Deferred revenue
Increase Decrease In Contract With Customer Liability
Accrued expenses and other liabilities
Increase Decrease In Accrued Liabilities And Other Operating Liabilities
Net cash provided by (used in) operating activities
Net Cash Provided By Used In Operating Activities
CASH FLOWS FROM INVESTING ACTIVITIES:
Net Cash Provided By Used In Investing Activities [Abstract]
Purchases of property and equipment
Payments To Acquire Property Plant And Equipment
Purchases of short-term investments
Payments To Acquire Short Term Investments
Proceeds from sales and maturities of short-term investments
Proceeds From Sale And Maturity Of Available For Sale Securities
Net cash (used in) provided by investing activities
Net Cash Provided By Used In Investing Activities
CASH FLOWS FROM FINANCING ACTIVITIES:
Net Cash Provided By Used In Financing Activities [Abstract]
Proceeds from issuance of common stock, net
Proceeds From Issuance Of Common Stock
Proceeds from term loan agreement, net
Proceeds From Debt Net Of Issuance Costs
Proceeds from Employee Stock Purchase Plan
Proceeds From Stock Plans
Proceeds from exercise of stock options
Proceeds From Stock Options Exercised
Other
Proceeds From Payments For Other Financing Activities
Net cash provided by financing activities
Net Cash Provided By Used In Financing Activities
NET INCREASE (DECREASE) IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect
CASH, CASH EQUIVALENTS AND RESTRICTED CASH—beginning of year
Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Including Disposal Group And Discontinued Operations
CASH, CASH EQUIVALENTS AND RESTRICTED CASH—end of year
Restricted cash included in current and noncurrent assets
Documents Incorporated by Reference
Documents Incorporated By Reference [Text Block]
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Nature of Business
Nature Of Operations
Accounting Policies [Abstract]
Basis of Presentation
Business Description And Basis Of Presentation [Text Block]
Summary of Significant Accounting Policies
Significant Accounting Policies [Text Block]
Collaborative research and license agreements.
Research And Development [Abstract]
Collaborative Research and License Agreements
Collaborative Research And License Agreements [Text Block]
Lessee Disclosure [Abstract]
Leases
Lessee Operating Leases [Text Block]
Earnings (Loss) per Share
Earnings Per Share [Text Block]
Significant agreements disclosure.
Equity [Abstract]
Significant Agreements
Significant Agreements Disclosure [Text Block]
Property Plant And Equipment [Abstract]
Property and Equipment, net
Property Plant And Equipment Disclosure [Text Block]
Fair Value Disclosures [Abstract]
Fair Value Measurements
Fair Value Measurement Inputs Disclosure [Text Block]
Deferred Costs Capitalized Prepaid And Other Assets Disclosure [Abstract]
Prepaid Expenses and Other Current Assets
Other Current Assets [Text Block]
Payables And Accruals [Abstract]
Accrued Expenses and Other Current Liabilities
Accounts Payable Accrued Liabilities And Other Liabilities Disclosure Current [Text Block]
Common stock disclosure.
Common Stock
Common Stock Disclosure [Text Block]
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Stock-Based Compensation
Disclosure Of Compensation Related Costs Share Based Payments [Text Block]
Debt Disclosure [Abstract]
Loan Payable
Debt Disclosure [Text Block]
Income Tax Disclosure [Abstract]
Income Taxes
Income Tax Disclosure [Text Block]
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies
Commitments And Contingencies Disclosure [Text Block]
Supplemental Cash Flow Elements [Abstract]
Supplemental Cash Flow Information
Cash Flow Supplemental Disclosures [Text Block]
Estimates
Use Of Estimates
Cash Equivalents
Cash And Cash Equivalents Policy [Text Block]
Restricted Cash
Cash And Cash Equivalents Restricted Cash And Cash Equivalents Policy
Short-Term Investments
Marketable Securities Policy
Segment Reporting
Segment Reporting Policy Policy [Text Block]
Concentrations of Credit Risk
Concentration Risk Credit Risk
Property and Equipment
Property Plant And Equipment Policy [Text Block]
Impairment of Long-Lived Assets
Impairment Or Disposal Of Long Lived Assets Policy [Text Block]
Debt Issuance Cost
Debt Policy [Text Block]
Derivative Financial Instruments
Derivatives Policy [Text Block]
Revenue Recognition
Revenue From Contract With Customer Policy [Text Block]
Research and Development
Research And Development Expense Policy
Clinical trial costs.
Clinical Trial Costs
Clinical Trial Costs Policy [Text Block]
Income Taxes
Income Tax Policy [Text Block]
Guarantees and Indemnifications
Guarantees Indemnifications And Warranties Policies
Stock-Based Compensation
Share Based Compensation Option And Incentive Plans Policy
Earnings (Loss) Per Share
Earnings Per Share Policy [Text Block]
Recently Issued and Adopted Accounting Pronouncements
New Accounting Pronouncements Policy Policy [Text Block]
Summary of Future Minimum Lease Payments under Operating Leases
Lessee Operating Lease Liability Maturity Table [Text Block]
Computation of Basic and Diluted Earnings (Loss) per Share
Schedule Of Earnings Per Share Basic And Diluted Table [Text Block]
Potential Dilutive Securities Excluded from Computation of Diluted Net Earnings (Loss) Loss per Common Share
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Text Block]
Property and Equipment, Net
Property Plant And Equipment [Text Block]
Schedule of Fair Values of Financial Assets and Liabilities Measured at Fair Value
Schedule Of Fair Value Assets And Liabilities Measured On Recurring Basis Table [Text Block]
Significant Unobservable Inputs in the Fair Value Measurement
Fair Value By Balance Sheet Grouping [Text Block]
Summary of Fair Value
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Text Block]
Summary of Available-for-Sale Securities
Debt Securities Available For Sale Table [Text Block]
Schedule of Prepaid Expenses and Other Current Assets
Deferred Costs Capitalized Prepaid And Other Assets Disclosure [Text Block]
Schedule of Accrued Expenses and Other Current Liabilities
Schedule Of Accounts Payable And Accrued Liabilities Table [Text Block]
Schedule of Common Stock Reserved for Future Issuance
Schedule Of Stockholders Equity Note Warrants Or Rights [Text Block]
Share Based Compensation Expense Related to Issuance of Stock Option Awards to Employees and Non Employees Related to Employee Stock Purchase Plan
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Text Block]
Grant Date Fair Values of Options Issued to Employees and Non-employees Estimated Using Black-Scholes Option Pricing Model
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis Valuation Techniques Table [Text Block]
Summary of Employee and Non-Employee Option Activity
Schedule Of Share Based Compensation Stock Options Activity Table [Text Block]
Summary of Restricted Stock Units Activity
Schedule Of Share Based Compensation Restricted Stock Units Award Activity Table [Text Block]
Summary of Maturities of Principal Obligations Under Long-term Debt
Schedule Of Maturities Of Long Term Debt Table [Text Block]
Schedule of Reconciliation of Provision for Income Taxes Computed at Statutory Federal Income Tax Rate to Provision for Income Taxes
Schedule Of Effective Income Tax Rate Reconciliation Table [Text Block]
Components of Deferred Tax
Schedule Of Deferred Tax Assets And Liabilities Table [Text Block]
Summary of Reconciliation of Company's Unrecognized Tax Benefits
Summary Of Income Tax Contingencies [Text Block]
Supplemental Disclosures of Cash Flow Information
Schedule Of Cash Flow Supplemental Disclosures Table [Text Block]
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Statistical Measurement
Range [Axis]
Statistical Measurement
Range [Member]
Minimum [Member]
Minimum [Member]
Maximum [Member]
Maximum [Member]
Cost-Sharing Collaborations [Member]
Collaborative Arrangement [Member]
Guarantor Obligations, Nature
Guarantee Obligations By Nature [Axis]
Guarantor Obligations, Nature
Guarantee Obligations Nature [Domain]
Guarantees and Indemnifications [Member]
Indemnification Guarantee [Member]
Accounting Standards Update
Adjustments For New Accounting Pronouncements [Axis]
Accounting Standards Update
Type Of Adoption [Member]
ASU No. 2019-12 [Member]
Accounting Standards Update201912 [Member]
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Number of operating segments
Number Of Operating Segments
Estimated useful lives
Property Plant And Equipment Useful Life
Impairment charge
Tangible Asset Impairment Charges
Costs related to cost sharing collaborations.
Increase decrease in research and development expense.
External costs related to cost-sharing collaborations
Costs Related To Cost Sharing Collaborations
Cost-sharing collaborations recorded as a reduction to research and development expense
Increase Decrease In Research And Development Expense
Percentage of income tax contingency realized.
Percentage of income tax contingency realized
Percentage Of Income Tax Contingency Realized
Indemnification obligations claims reserves.
Indemnification obligations, claims outstanding
Loss Contingency Pending Claims Number
Indemnification obligations claims, reserves established
Indemnification Obligations Claims Reserves
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Change In Accounting Principle Accounting Standards Update Adoption Date
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Change In Accounting Principle Accounting Standards Update Adopted
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Change In Accounting Principle Accounting Standards Update Immaterial Effect
Development costs associated with clinical trials.
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Schedule Of Research And Development Arrangement Contract To Perform For Others [Table]
Incyte Agreement [Member]
Geographical
Statement Geographical [Axis]
Geographical
Segment Geographical [Domain]
Global and united states.
Global and U.S. [Member]
Global And United States [Member]
Ex-U.S. Countries [Member]
Non Us [Member]
Counterparty Name
Counterparty Name [Axis]
Counterparty Name
Repurchase Agreement Counterparty Name [Domain]
Incyte corporation.
Incyte Corporation [Member]
Incyte Corporation [Member]
Asset Class
Fair Value By Asset Class [Axis]
Asset Class
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation By Asset Class [Domain]
Non refundable cash payments.
Non-Refundable Cash Payments [Member]
Non Refundable Cash Payments [Member]
License agreement.
License Agreement [Member]
License Agreement [Member]
Kyowa Kirin Co., Ltd.
Kyowa Kirin Co., Ltd. [Member]
Kyowa Kirin Co Ltd [Member]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Development costs associated with clinical trials
Development Costs Associated With Clinical Trials
Upfront payments.
Potential milestone payments upon achievement of milestone.
Commercialization milestones and tiered royalties.
Upfront milestone payable
Upfront Payments
Potential milestone payments to be made
Potential Milestone Payments Upon Achievement Of Milestone
Commercialization milestones and tiered royalties
Commercialization Milestones And Tiered Royalties
Upfront payments received.
Collaboration and license agreement cash consideration.
License agreement upfront payment received
Upfront Payments Received
Common stock shares purchased
Purchase price per share
Shares Issued Price Per Share
Aggregate purchase price
Total cash consideration
Collaboration And License Agreement Cash Consideration
Collaboration and license agreement allocated consideration received to derivative liability.
Upfront payments to be returned upon termination of agreement.
Common stock issued at fair value
Allocated consideration received to derivative liability
Collaboration And License Agreement Allocated Consideration Received To Derivative Liability
Upfront payments returned upon termination of agreement
Upfront Payments To Be Returned Upon Termination Of Agreement
Collaboration and license agreement consideration transaction price.
Estimated standalone selling price of license agreement.
Revenue recognized upon transfer of license agreement.
Total transaction price
Collaboration And License Agreement Consideration Transaction Price
Estimated standalone selling price of license agreement
Estimated Standalone Selling Price Of License Agreement
Revenue recognized upon transfer of license agreement
Revenue Recognized Upon Transfer Of License Agreement
Upfront payment allocated to equity purchase.
Non refundable up front payment received.
Potential milestone payments receivable.
Period of termination after first commercial sale of first licensed product.
Up-front payment allocated to equity purchase
Upfront Payment Allocated To Equity Purchase
Up-front license fee received
Non Refundable Up Front Payment Received
Milestone payment receivable upon achievement of development and commercial milestone
Potential Milestone Payments Receivable
Period of termination after first commercial sale of first licensed product
Period Of Termination After First Commercial Sale Of First Licensed Product
Upfront payments allocated to equity purchase fair value.
Upfront payment allocated to license fee.
Up-front payment allocated to preferred stock value
Upfront Payments Allocated To Equity Purchase Fair Value
Up-front payment allocated to license fee
Upfront Payment Allocated To License Fee
Revenue from contract with customer milestone method factors.
Milestone payment agreement terms
Revenue From Contract With Customer Milestone Method Factors
Milestone payment received
Contract With Customer Liability Revenue Recognized
Upfront payment allocation to performance obligation
Revenue Remaining Performance Obligation
Performance obligation period
Revenue Remaining Performance Obligation Expected Timing Of Satisfaction Year1
Deferred revenue
Contract With Customer Liability
Lessee Lease Description [Table]
Lessee Lease Description [Table]
Waltham, Massachusetts [Member]
MASSACHUSETTS
New York [Member]
NEW YORK
Lessee Lease Description [Line Items]
Lessee Lease Description [Line Items]
Lease option to extend
Lessee Operating Lease Existence Of Option To Extend
Lease option to termination
Lessee Operating Lease Existence Of Option To Terminate
Lease commencement date.
Operating lease term of contract
Lessor Operating Lease Term Of Contract
Area of leased property
Area Of Real Estate Property
Lease Commencement Date
Lease Commencement Date
Remaining lease term
Operating Lease Weighted Average Remaining Lease Term1
Right-of-use asset, net
Lease liability
Operating Lease Liability
Operating lease discount rate
Operating Lease Weighted Average Discount Rate Percent
Operating lease expense
Operating Lease Expense
Lease payments
Operating Lease Payments
Lessee, Operating Lease, Option to Extend
Lessee Operating Lease Option To Extend
Operating Lease Liabilities Payments Due [Abstract]
2021
Lessee Operating Lease Liability Payments Due Next Twelve Months
2022
Lessee Operating Lease Liability Payments Due Year Two
2023
Lessee Operating Lease Liability Payments Due Year Three
Thereafter
Lessee Operating Lease Liability Payments Due After Year Three
Total lease payments
Lessee Operating Lease Liability Payments Due
Less: imputed interest
Lessee Operating Lease Liability Undiscounted Excess Amount
Future minimum lease payments under capital leases
Finance Lease Liability Payments Due
Schedule Of Earnings Per Share Basic By Common Class [Table]
Schedule Of Earnings Per Share Basic By Common Class [Table]
Award Type
Award Type [Axis]
Award Type
Share Based Compensation Arrangements By Share Based Payment Award Award Type And Plan Name [Domain]
Options to Purchase Common Stock [Member]
Employee Stock Option [Member]
Non-Vested Restricted Stock Units (RSUs) [Member]
Restricted Stock Units R S U [Member]
ESPP to Purchase Common Stock
Employee Stock [Member]
Earnings Per Share Basic [Line Items]
Earnings Per Share Basic [Line Items]
Numerator:
Net Income Loss [Abstract]
Net income (loss)
Deemed dividend due to warrant reset
Warrant Down Round Feature Increase Decrease In Equity Amount
Net income (loss) attributable to common stockholders
Denominator:
Weighted-average common shares outstanding
Dilutive potential common shares
Incremental Common Shares Attributable To Share Based Payment Arrangements
Shares used in calculating diluted earnings (loss) per share
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Antidilutive Securities
Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities [Axis]
Antidilutive Securities, Name
Antidilutive Securities Name [Domain]
Warrants to purchase common stock.
Warrants to Purchase Common Stock [Member]
Warrants To Purchase Common Stock [Member]
Employee stock purchase plan.
Employee Stock Purchase Plan [Member]
Employee Stock Purchase Plan [Member]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Anti-dilutive securities excluded from computation of diluted net loss per common share
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount
Number of common stock converted to warrants.
Number of common stock warrants issued.
Class of warrant or right issued.
Number of pre-funded warrants exchanged for common stock.
Number of pre funded warrants cashless exchanged for common stock.
Pre funded warrants.
Pre-Funded Warrants [Member]
Pre Funded Warrants [Member]
Biotechnology Value Fund, L.P.
Biotechnology Value Fund, L.P. [Member]
Biotechnology Value Fund L P [Member]
Number of common stock converted to warrants
Number Of Common Stock Converted To Warrants
Number of common stock warrants issued
Number Of Common Stock Warrants Issued
Warrant issued
Class Of Warrant Or Right Issued
Warrant exercise price per share
Class Of Warrant Or Right Exercise Price Of Warrants Or Rights1
Pre-funded warrants exchange
Number Of Pre Funded Warrants Exchanged For Common Stock
Pre-funded warrants cashless exchange
Number Of Pre Funded Warrants Cashless Exchanged For Common Stock
Warrants outstanding
Class Of Warrant Or Right Outstanding
License agreements expiration period.
Aggregate potential milestone payable.
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Allergan license agreement.
Allergan License Agreement [Member]
Allergan License Agreement [Member]
Vitae Pharmaceuticals, Inc.
Vitae Pharmaceuticals Inc [Member]
Vitae Pharmaceuticals Inc [Member]
UCB license agreement.
UCB License Agreement [Member]
Ucb License Agreement [Member]
UCB Biopharma.
UCB Biopharma [Member]
U C B Biopharma [Member]
Clinical trial.
Clinical Trial [Member]
Clinical Trial [Member]
Eastern Cooperative Oncology Group.
Eastern Cooperative Oncology Group [Member]
Eastern Cooperative Oncology Group [Member]
Bayer Pharma AG .
Bayer Pharma AG [Member]
Bayer Pharma Ag [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Aggregate potential milestone payable
Aggregate Potential Milestone Payable
License expiration year
License Agreements Expiration Period
Research and development expense
Accrued milestone expenses.
Accrued milestone expenses
Accrued Milestone Expenses
Milestone payment due.
Increase decrease in contractual obligation.
Remaining contractual obligation.
Contractual obligations term.
Accrued contractual obligation.
Milestone payment payable
Milestone Payment Due
Increase in contractual obligation
Increase Decrease In Contractual Obligation
Aggregate payment obligation
Contractual Obligation
Remaining contractual obligation
Remaining Contractual Obligation
Period of contractual obligation
Contractual Obligations Term
Accrued contractual obligation
Accrued Contractual Obligation
Upfront license fees paid.
Up-front license fee paid
Upfront License Fees Paid
Schedule Of Property Plant And Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Long-Lived Tangible Asset
Property Plant And Equipment By Type [Axis]
Long-Lived Tangible Asset
Property Plant And Equipment Type [Domain]
Equipment [Member]
Equipment [Member]
Leasehold Improvements [Member]
Leasehold Improvements [Member]
Furniture and Fixtures [Member]
Furniture And Fixtures [Member]
Office and computer equipment.
Office and Computer Equipment [Member]
Computer And Office Equipment [Member]
Office Equipment Under Capital Lease [Member]
Office Equipment [Member]
Property Plant And Equipment [Line Items]
Property Plant And Equipment [Line Items]
Property and equipment, gross
Property Plant And Equipment Gross
Accumulated depreciation
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Property and equipment, net
Depreciation expense
Depreciation
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Fair Value Hierarchy and NAV
Fair Value By Fair Value Hierarchy Level [Axis]
Fair Value Hierarchy and NAV
Fair Value Measurements Fair Value Hierarchy [Domain]
Quoted Prices in Active Markets Level 1 [Member]
Fair Value Inputs Level1 [Member]
Significant Other Observable Inputs Level 2 [Member]
Fair Value Inputs Level2 [Member]
Significant Unobservable Inputs Level 3 [Member]
Fair Value Inputs Level3 [Member]
Measurement Basis
Fair Value By Measurement Basis [Axis]
Fair Value Disclosure Item Amounts [Default]
Portion At Fair Value Fair Value Disclosure [Member]
Fair Value Measurement
Fair Value Disclosure Item Amounts [Domain]
Carrying Value [Member]
Carrying Reported Amount Fair Value Disclosure [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Cash equivalents
Cash And Cash Equivalents Fair Value Disclosure
Total assets
Assets Fair Value Disclosure
Derivative Liability
Derivative Liabilities
Total Liabilities
Liabilities Fair Value Disclosure
Derivative liability expected timing of the termination right.
Fair value measurements.
Fair Value Measurements [Table]
Fair Value Measurements [Table]
Fair Value Measurements [Table]
Weighted Average [Member]
Weighted Average [Member]
Valuation Approach and Technique
Valuation Technique [Axis]
Valuation Approach and Technique
Valuation Technique [Domain]
Valuation technique Black Scholes Model.
Black Scholes Model [Member]
Valuation Technique Black Scholes Model [Member]
Measurement Input Type
Measurement Input Type [Axis]
Measurement Input Type
Measurement Input Type [Domain]
Discount Rate [Member]
Measurement Input Discount Rate [Member]
Volatility [Member]
Measurement Input Option Volatility [Member]
Measurement Input, Expected Term [Member]
Measurement Input Expected Term [Member]
Fair Value Measurements [Line Items]
Fair Value Measurements [Line Items]
Derivative Liability, Measurement Input
Derivative Liability Measurement Input
Expected timing of the Termination Right
Derivative Liability Expected Timing Of Termination Right
Fair value measurement with unobservable inputs reconciliations recurring basis liability value additions.
Fair Value Measurement With Unobservable Inputs Reconciliations Recurring Basis Liability Change In Fair Value
Derivative Liability:
Derivative Liabilities [Abstract]
Beginning Balance 1/1/2021
Fair Value Measurement With Unobservable Inputs Reconciliations Recurring Basis Liability Value
Additions
Fair Value Measurement With Unobservable Inputs Reconciliations Recurring Basis Liability Value Additions
Change in fair value
Fair Value Measurement With Unobservable Inputs Reconciliations Recurring Basis Liability Change In Fair Value
Ending Balance 12/31/2021
Realized gains or losses recognized on the sale or maturity of available-for-sale securities
Debt Securities Available For Sale Realized Gain Loss
Available For Sale Securities Fair Value Disclosure [Abstract]
Available For Sale Securities Fair Value Disclosure [Abstract]
Debt Securities Available For Sale [Table]
Debt Securities Available For Sale [Table]
Commercial Paper [Member]
Commercial Paper Not Included With Cash And Cash Equivalents [Member]
Corporate Bonds [Member]
Corporate Debt Securities [Member]
U.S. Treasury [Member]
U S Treasury Securities [Member]
Schedule Of Available For Sale Securities [Line Items]
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost
Available For Sale Debt Securities Amortized Cost Basis
Unrealized Gains
Available For Sale Debt Securities Accumulated Gross Unrealized Gain Before Tax
Unrealized Losses
Available For Sale Debt Securities Accumulated Gross Unrealized Loss Before Tax
Fair Value
Available For Sale Securities Debt Securities
Reimbursable costs.
Short-term deposits
Deposits Assets Current
Prepaid insurance
Prepaid Insurance
Interest receivable on investments
Interest Receivable Current
Prepaid clinical supplies
Supplies
Reimbursable costs
Reimbursable Costs
Other
Other Prepaid Expense Current
Total prepaid expenses and other current assets
Accrued clinical costs current.
Accrued clinical costs
Accrued Clinical Costs Current
Accrued compensation and related costs
Employee Related Liabilities Current
Accrued professional fees
Accrued Professional Fees Current
Other
Other Accrued Liabilities Current
Total accrued expenses
Schedule Of Stock By Class [Table]
Schedule Of Stock By Class [Table]
Initial Public Offering [Member]
I P O [Member]
Legal Entity
Legal Entity [Axis]
Entity
Entity [Domain]
Cowen and Company LLC.
Cowen and Company LLC [Member]
Cowen And Company L L C [Member]
Related Party Transaction
Related Party Transaction [Axis]
Related Party Transaction
Related Party Transaction [Domain]
At the market equity offering sales agreement.
At The Market Equity Offering Sales Agreement [Member]
At The Market Equity Offering Sales Agreement [Member]
Series warrants.
Series Warrants [Member]
Series Warrants [Member]
Series one warrants.
Series 1 Warrants [Member]
Series One Warrants [Member]
Series two warrants.
Series 2 Warrants [Member]
Series Two Warrants [Member]
Series one and series two warrants.
Series 1 and Series 2 Warrants [Member]
Series One And Series Two Warrants [Member]
Incyte collaboration agreement and share purchase agreement.
Incyte Collaboration Agreement and Share Purchase Agreement [Member]
Incyte Collaboration Agreement And Share Purchase Agreement [Member]
Class Of Stock [Line Items]
Class Of Stock [Line Items]
Proceeds from issuance of common stock in follow-on public stock offering, net
Common stock, new shares issued
Warrant expiration term.
Exercise of warrants upper limit after exercise as percentage of common stock.
Warrant exercise price per share
Warrant expiration period
Warrant Expiration Term
Maximum percentage of common stock can be held upon exercise of warrant
Exercise Of Warrants Upper Limit After Exercise As Percentage Of Common Stock
Number of series of warrants.
Class of warrant or right term.
Offering price per share.
Gross proceeds from offering.
Offering cost.
Number of series of warrants
Number Of Series Of Warrants
Warrants issued (in shares)
Class Of Warrant Or Right Number Of Securities Called By Warrants Or Rights
Warrant term
Class Of Warrant Or Right Term
Offering price
Offering Price Per Share
Gross proceeds from offering
Gross Proceeds From Offering
Offering costs
Offering Cost
Warrants exercised period.
Warrants exercised period
Warrants Exercised Period
Maximum period allowed to increase beneficial ownership limitation after notice.
Exercise of warrants lower limit after exercise as percentage of common stock.
Maximum beneficial ownership limitation percentage.
Maximum period allowed to increase beneficial ownership limitation after notice
Maximum Period Allowed To Increase Beneficial Ownership Limitation After Notice
Minimum percentage of common stock can be held upon exercise of warrant
Exercise Of Warrants Lower Limit After Exercise As Percentage Of Common Stock
Maximum beneficial ownership limitation percentage
Maximum Beneficial Ownership Limitation Percentage
Fair value of warrants.
Number of warrants exercised in cashless exercise.
Total fair value of warrant
Fair Value Of Warrants
Warrants and rights outstanding, measurement input
Warrants And Rights Outstanding Measurement Input
Weighted average expected term
Warrants And Rights Outstanding Term
Warrants exercised
Number Of Warrants Exercised In Cashless Exercise
Shares issued for exercise of warrants
Deemed dividend transferred to the warrant holders
Common stock reserved for future issuance
Common Stock Capital Shares Reserved For Future Issuance
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Plan Name
Plan Name [Axis]
Plan Name
Plan Name [Domain]
Two thousand fifteen omnibus incentive plan.
2015 Plan [Member]
Two Thousand Fifteen Omnibus Incentive Plan [Member]
Subsequent Event Type
Subsequent Event Type [Axis]
Subsequent Event Type
Subsequent Event Type [Domain]
Subsequent Event [Member]
Subsequent Event [Member]
Two thousand seven and two thousand fifteen stock incentive plan.
2007 and 2015 [Member]
Two Thousand Seven And Two Thousand Fifteen Stock Incentive Plan [Member]
Performance Based Shares [Member]
Performance Shares [Member]
service based options.
Service Based Options [Member]
Service Based Options [Member]
Two thousand and seventeen performance awards.
2017 Performance Awards [Member]
Two Thousand And Seventeen Performance Awards [Member]
Title of Individual
Title Of Individual [Axis]
Title of Individual
Title Of Individual With Relationship To Entity [Domain]
Employees.
Employees [Member]
Employees [Member]
Two thousand and nineteen performance awards.
2019 Performance Awards
Two Thousand And Nineteen Performance Awards [Member]
Two thousand and seven stock incentive plan.
2007 Plan [Member]
Two Thousand And Seven Stock Incentive Plan [Member]
Scenario
Statement Scenario [Axis]
Scenario
Scenario Unspecified [Domain]
Scenario Forecast [Member]
Scenario Forecast [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock reserved for issuance
Share Based Compensation Arrangement By Share Based Payment Award Number Of Shares Available For Grant
Shares available for issuance
Share based compensation arrangement by share based payment award annual increase percentage in number of shares available for grant.
Common stock outstanding
Share Based Compensation Arrangement By Share Based Payment Award Annual Increase Percentage In Number Of Shares Available For Grant
Income Statement Location
Income Statement Location [Axis]
Income Statement Location
Income Statement Location [Domain]
Research and Development [Member]
Research And Development Expense [Member]
General and Administrative [Member]
General And Administrative Expense [Member]
Share based compensation expense, total
Allocated Share Based Compensation Expense
Unrecognized compensation expense related to stock option
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Stock Options
Weighted average period to recognize compensation expense
Employee Service Share Based Compensation Nonvested Awards Total Compensation Cost Not Yet Recognized Period For Recognition1
Employee service share based compensation recognized stock options.
Share-based compensation, stock options granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Gross
Share-based compensation, stock options vested
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Number
Share-based compensation, stock options cancelled
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures In Period
Stock compensation expense
Employee Service Share Based Compensation Recognized Stock Options
Stock option granted to certain employees
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period
Employee service share based compensation recognized stock options not met.
Recognized compensation expense related to stock option not met
Employee Service Share Based Compensation Recognized Stock Options Not Met
Number of employees retirement.
Share-based compensation, stock options vested
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested Number Of Shares
Number of employees retirement
Number Of Employees Retirement
Stock compensation expense
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions And Methodology [Abstract]
Expected term (in years)
Sharebased Compensation Arrangement By Sharebased Payment Award Fair Value Assumptions Expected Term1
Volatility rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Volatility Rate
Risk-free interest rate
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Risk Free Interest Rate
Expected dividend yield
Share Based Compensation Arrangement By Share Based Payment Award Fair Value Assumptions Expected Dividend Rate
Share Based Arrangements To Obtain Goods And Services [Abstract]
Options outstanding, Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number
Options granted
Options exercised
Options canceled, forfeited or expired
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period
Options outstanding, Ending balance
Options exercisable, Ending balance
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Number
Options vested, exercisable or expected to vest, Ending balance
Options outstanding, Weighted Average Exercise Price, Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price
Options granted, Weighted Average Exercise Price
Share Based Compensation Arrangements By Share Based Payment Award Options Grants In Period Weighted Average Exercise Price
Options exercised, Weighted Average Exercise Price
Share Based Compensation Arrangements By Share Based Payment Award Options Exercises In Period Weighted Average Exercise Price
Options canceled, forfeited or expired, Weighted Average Exercise Price
Share Based Compensation Arrangement By Share Based Payment Award Options Forfeitures And Expirations In Period Weighted Average Exercise Price
Options outstanding, Weighted Average Exercise Price, Ending balance
Options exercisable, Weighted Average Exercise Price, Ending balance
Share Based Compensation Arrangement By Share Based Payment Award Options Exercisable Weighted Average Exercise Price
Options vested, exercisable or expected to vest, Weighted Average Exercise Price, Ending balance
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Exercise Price
Options outstanding, Weighted Average Remaining Contractual Term
Sharebased Compensation Arrangement By Sharebased Payment Award Options Outstanding Weighted Average Remaining Contractual Term2
Options exercisable, Weighted Average Remaining Contractual Term, Ending balance
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Weighted Average Remaining Contractual Term1
Options vested, exercisable or expected to vest, Weighted Average Remaining Contractual Term, Ending balance
Sharebased Compensation Arrangement By Sharebased Payment Award Options Vested And Expected To Vest Outstanding Weighted Average Remaining Contractual Term1
Share based compensation arrangement by share based payment award options canceled, forfeited or expired in period total intrinsic value.
Options outstanding, Aggregate Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Intrinsic Value
Options Exercised, Aggregate Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Exercises In Period Total Intrinsic Value
Options Canceled, forfeited or expired, Aggregate Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Canceled Forfeited Or Expired In Period Total Intrinsic Value
Options exercisable, Aggregate Intrinsic Value
Sharebased Compensation Arrangement By Sharebased Payment Award Options Exercisable Intrinsic Value1
Options vested, exercisable or expected to vest, Aggregate Intrinsic Value
Share Based Compensation Arrangement By Share Based Payment Award Options Vested And Expected To Vest Outstanding Aggregate Intrinsic Value
Weighted-average grant date fair value of options granted
Share Based Compensation Arrangement By Share Based Payment Award Options Grants In Period Weighted Average Grant Date Fair Value
Vesting period
Share Based Compensation Arrangement By Share Based Payment Award Award Vesting Period1
Stock options exercised, shares
Stock options exercised
Intrinsic value of options exercised
Number of Shares, Unvested, Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Number
Number of Shares, Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period
Number of Shares, Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period
Number of Shares, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeited In Period
Number of Shares, Unvested, Ending balance
Weighted Average Grant Date Fair Value, Unvested, Beginning balance
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Nonvested Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Granted
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Grants In Period Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Forfeited
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Forfeitures Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Unvested, Ending balance
Restricted stock units granted
Fair value of restricted stock units vested
Share Based Compensation Arrangement By Share Based Payment Award Equity Instruments Other Than Options Vested In Period Total Fair Value
Restricted stock units vested
Weighted average grant date fair value per share
Sharebased Compensation Arrangement By Sharebased Payment Award Options Nonvested Options Forfeited Weighted Average Grant Date Fair Value
Share-based compensation arrangement by share-based payment award payroll deductions offering period.
Share based compensation arrangement by share based payment award offering period discount rate.
Shares authorized for issuance
Share Based Compensation Arrangement By Share Based Payment Award Number Of Additional Shares Authorized
Number of shares issued under plan
Periodic payroll deductions offering periods
Share Based Compensation Arrangement By Share Based Payment Award Payroll Deductions Offering Period
Offering period discount rate
Share Based Compensation Arrangement By Share Based Payment Award Offering Period Discount Rate
Contributions by the company
Defined Contribution Plan Employer Discretionary Contribution Amount
Line of credit facility elected not to draw.
Payment of facility charges.
Debt Instrument [Table]
Debt Instrument [Table]
Lender Name
Line Of Credit Facility [Axis]
Line of Credit Facility, Lender
Line Of Credit Facility Lender [Domain]
Hercules Capital, Inc.
Hercules [Member]
Hercules Capital Inc [Member]
Credit Facility
Credit Facility [Axis]
Credit Facility
Credit Facility [Domain]
Loan and security agreement.
Loan Agreement [Member]
Loan And Security Agreement [Member]
Debt Instrument
Debt Instrument [Axis]
Debt Instrument, Name
Debt Instrument Name [Domain]
Term loan.
Term Loan [Member]
Term Loan [Member]
Additional term loan.
Additional Term Loan [Member]
Additional Term Loan [Member]
Variable Rate
Variable Rate [Axis]
Variable Rate
Variable Rate [Domain]
Wall Street Journal Prime Rate [Member]
Prime Rate [Member]
First amendment to loan and security agreement.
First Amendment to Loan Agreement [Member]
First Amendment To Loan And Security Agreement [Member]
Debt instrument tranche two
Tranche 2 [Member]
Debt Instrument Tranche Two [Member]
Debt instrument, tranche three.
Tranche 3 [Member]
Debt Instrument Tranche Three [Member]
Scenario one.
Available through April 30, 2022 [Member]
Scenario One [Member]
Scenario two.
Available through November 30, 2022 [Member]
Scenario Two [Member]
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Aggregate maximum borrowings
Line Of Credit Facility Maximum Borrowing Capacity
Line of credit facility elected not to draw
Line Of Credit Facility Elected Not To Draw
Interest rate description
Line Of Credit Facility Interest Rate Description
Interest rate
Debt Instrument Interest Rate Stated Percentage
Basis spread on variable rate
Debt Instrument Basis Spread On Variable Rate1
Facility charge paid
Payment Of Facility Charges
Aggregate maximum borrowing capacity increase
Line Of Credit Facility Increase Decrease For Period Net
Borrowings to date
Debt Instrument Carrying Amount
Percentage of prepayment premium of principal amount outstanding in first year.
Percentage of prepayment premium of principal amount outstanding in second year.
Percentage of prepayment premium of principal amount outstanding thereafter.
Percentage of end of term charge to future draws.
Percentage of facility charge of future draws.
Debt instrument interest only period expiration date.
Debt instrument interest only period extendable upon partial or full draw of Tranche 2.
Interest-only period, terms
Line Of Credit Facility Frequency Of Payment And Payment Terms
Interest-only period expiration date
Debt Instrument Interest Only Period Expiration Date
Interest-only period, extendable upon partial or full draw of Tranche 2
Debt Instrument Interest Only Period Extendable Upon Partial Or Full Draw Of Tranche Two
Maturity date
Debt Instrument Maturity Date
Percentage of prepayment premium of principal amount outstanding in first year
Percentage Of Prepayment Premium Of Principal Amount Outstanding In First Year
Percentage of prepayment premium of principal amount outstanding in second year
Percentage Of Prepayment Premium Of Principal Amount Outstanding In Second Year
Percentage of prepayment premium of principal amount outstanding thereafter prior to maturity date
Percentage Of Prepayment Premium Of Principal Amount Outstanding Thereafter
Percentage of facility charge of future draws
Percentage Of Facility Charge Of Future Draws
Percentage of end of term charge to future draws
Percentage Of End Of Term Charge To Future Draws
Line of credit facility minimum cash covenant.
Additional default interest rate.
Line of credit facility minimum cash covenant waived.
Minimum cash covenant
Line Of Credit Facility Minimum Cash Covenant
Minimum cash covenant waived
Line Of Credit Facility Minimum Cash Covenant Waived
Default interest rate
Additional Default Interest Rate
Interest expense related to the loan agreement
Interest Expense Debt
Amortized losses reacquired debt noncurrent.
2022
Long Term Debt Maturities Repayments Of Principal In Next Twelve Months
2023
Long Term Debt Maturities Repayments Of Principal In Year Two
2024
Long Term Debt Maturities Repayments Of Principal In Year Three
Total principal outstanding
Amortized final fee
Amortized Losses Reacquired Debt Noncurrent
Unamortized debt issuance costs
Unamortized Debt Issuance Expense
Total
Loans Payable
Income taxes.
Income Taxes [Table]
Income Taxes [Table]
Income Taxes [Table]
Income Tax Authority
Income Tax Authority [Axis]
Income Tax Authority
Income Tax Authority [Domain]
Federal [Member]
Domestic Country [Member]
State [Member]
State And Local Jurisdiction [Member]
Tax Period
Tax Period [Axis]
Tax Period
Tax Period [Domain]
Indefinite carryforward period.
Indefinite Carryforward Period [Member]
Indefinite Carryforward Period [Member]
Begin to expire in 2026.
Begin to Expire in 2026 [Member]
Begin To Expire In Two Thousand And Twenty Six [Member]
Income Tax Authority, Name
Income Tax Authority Name [Axis]
Income Tax Authority, Name
Income Tax Authority Name [Domain]
Internal Revenue Service [Member]
Internal Revenue Service I R S [Member]
Income Taxes [Line Items]
Income Taxes [Line Items]
Net tax provision
Income Tax Expense Benefit
Effective Income Tax Rate Continuing Operations Tax Rate Reconciliation [Abstract]
Income tax computed at federal statutory rate
Effective Income Tax Rate Reconciliation At Federal Statutory Income Tax Rate
State taxes, net of federal benefit
Effective Income Tax Rate Reconciliation State And Local Income Taxes
General business credit carryovers
Effective Income Tax Rate Reconciliation Tax Credits
Non-deductible expenses
Effective Income Tax Rate Reconciliation Nondeductible Expense
Change in valuation allowance
Effective Income Tax Rate Reconciliation Change In Deferred Tax Assets Valuation Allowance
Other
Effective Income Tax Rate Reconciliation Other Adjustments
Effective income tax rate
Effective Income Tax Rate Continuing Operations
Deferred tax asset, capitalized start-up and other costs.
Deferred tax asset, capitalized research and development costs.
Components Of Deferred Tax Assets [Abstract]
Deferred tax assets (liabilities):
Components Of Deferred Tax Assets And Liabilities [Abstract]
Net operating loss carryforwards
Deferred Tax Assets Operating Loss Carryforwards
Research and development credits
Deferred Tax Assets In Process Research And Development
Capitalized start-up and other costs
Deferred Tax Assets Capitalized Start Up And Other Costs
Capitalized research and development costs
Deferred Tax Assets Capitalized Research And Development Costs
Deferred revenue
Deferred Tax Assets Deferred Income
Equity based compensation
Deferred Tax Assets Tax Deferred Expense Compensation And Benefits Share Based Compensation Cost
Accruals
Deferred Tax Assets Tax Deferred Expense Reserves And Accruals Accrued Liabilities
Other temporary differences
Deferred Tax Assets Other
Deferred tax assets before valuation allowance
Deferred Tax Assets Gross
Valuation allowances
Deferred Tax Assets Valuation Allowance
Net deferred tax assets
Deferred Tax Assets Net
Increase (decrease) in valuation allowance
Valuation Allowance Deferred Tax Asset Change In Amount
Valuation allowance for deferred tax assets, description
Valuation Allowance Methodologies And Assumptions
Deferred tax assets operating loss carryforwards expiration period.
Deferred tax assets research credits expiration period.
Federal net operating losses
Deferred Tax Assets Operating Loss Carryforwards Domestic
State net operating losses
Deferred Tax Assets Operating Loss Carryforwards State And Local
Operating loss carryforward expiration period
Deferred Tax Assets Operating Loss Carryforwards Expiration Period
Deferred tax assets research credits
Deferred Tax Assets Tax Credit Carryforwards Research
Deferred tax assets research credits expiration period
Deferred Tax Assets Research Credits Expiration Period
Uncertain tax positions
Unrecognized Tax Benefits Period Increase Decrease
Interest or penalties recorded during the period
Unrecognized Tax Benefits Income Tax Penalties And Interest Expense
Unrecognized income tax benefits that would affect effective tax rate
Unrecognized Tax Benefits That Would Impact Effective Tax Rate
Reconciliation Of Unrecognized Tax Benefits Excluding Amounts Pertaining To Examined Tax Returns Roll Forward
Unrecognized tax benefit--beginning of year
Unrecognized Tax Benefits
Decreases related to prior period positions
Unrecognized Tax Benefits Decreases Resulting From Prior Period Tax Positions
Unrecognized tax benefit--end of year
Commitment and contingencies.
Commitment And Contingencies [Table]
Commitment And Contingencies [Table]
Commitment And Contingencies [Table]
Equity Investment [Member]
Equity Method Investments [Member]
Registration Payment Arrangement by Arrangement
Registration Payment Arrangement By Arrangement [Axis]
Registration Payment Arrangement, Arrangement
Registration Payment Arrangement Arrangement [Domain]
Series B-1 purchase agreement.
Eddingpharm Purchase Agreement [Member]
Series B1 Purchase Agreement [Member]
Commitment And Contingencies [Line Items]
Commitment And Contingencies [Line Items]
Purchase agreement obligation
Purchase Obligation
Contingent liabilities
Business Combination Contingent Consideration Liability
Supplemental Cash Flow Information [Abstract]
Supplemental Disclosures of Non-Cash Investing and Financing Activities:
Noncash Investing And Financing Items [Abstract]
Interest paid
Interest Paid Net
Issuance costs included in accounts payable and accrued expenses
Debt Issuance Costs Incurred During Noncash Or Partial Noncash Transaction