100000 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 100010 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 100020 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 100030 - Statement - Consolidated Statements of Operations link:presentationLink link:calculationLink link:definitionLink 100040 - Statement - Consolidated Statements of Comprehensive Income (Loss) link:presentationLink link:calculationLink link:definitionLink 100050 - Statement - Consolidated Statements of Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 100060 - Statement - Consolidated Statements of Stockholders' Equity (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 100070 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 100080 - Disclosure - Nature of Business link:presentationLink link:calculationLink link:definitionLink 100090 - Disclosure - Basis of Presentation link:presentationLink link:calculationLink link:definitionLink 100100 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 100110 - Disclosure - Collaborative Research and License Agreements link:presentationLink link:calculationLink link:definitionLink 100120 - Disclosure - Leases link:presentationLink link:calculationLink link:definitionLink 100130 - Disclosure - Earnings (Loss) per Share link:presentationLink link:calculationLink link:definitionLink 100140 - Disclosure - Significant Agreements link:presentationLink link:calculationLink link:definitionLink 100150 - Disclosure - Property and Equipment, net link:presentationLink link:calculationLink link:definitionLink 100160 - Disclosure - Fair Value Measurements link:presentationLink link:calculationLink link:definitionLink 100170 - Disclosure - Prepaid Expenses and Other Current Assets link:presentationLink link:calculationLink link:definitionLink 100180 - Disclosure - Accrued Expenses and Other Current Liabilities link:presentationLink link:calculationLink link:definitionLink 100190 - Disclosure - Common Stock link:presentationLink link:calculationLink link:definitionLink 100200 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 100210 - Disclosure - Loan Payable link:presentationLink link:calculationLink link:definitionLink 100220 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 100230 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 100240 - Disclosure - Supplemental Cash Flow Information link:presentationLink link:calculationLink link:definitionLink 100250 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 100260 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 100270 - Disclosure - Earnings (Loss) per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 100280 - Disclosure - Property and Equipment, net (Tables) link:presentationLink link:calculationLink link:definitionLink 100290 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 100300 - Disclosure - Prepaid Expenses and Other Current Assets (Tables) link:presentationLink link:calculationLink link:definitionLink 100310 - Disclosure - Accrued Expenses and Other Current Liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 100320 - Disclosure - Common Stock (Tables) link:presentationLink link:calculationLink link:definitionLink 100330 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 100340 - Disclosure - Loan Payable (Tables) link:presentationLink link:calculationLink link:definitionLink 100350 - Disclosure - Income Taxes (Tables) link:presentationLink link:calculationLink link:definitionLink 100360 - Disclosure - Supplemental Cash Flow Information (Tables) link:presentationLink link:calculationLink link:definitionLink 100370 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100380 - Disclosure - Collaborative Research and License Agreements - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100390 - Disclosure - Leases - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100400 - Disclosure - Leases - Summary of Future Minimum Lease Payments under Operating Leases (Detail) link:presentationLink link:calculationLink link:definitionLink 100410 - Disclosure - Earnings (Loss) per Share - Computation of Basic and Diluted Earnings (Loss) per Share (Detail) link:presentationLink link:calculationLink link:definitionLink 100420 - Disclosure - Earnings (Loss) per Share - Potential Dilutive Securities Excluded from Computation of Diluted Net Loss per Common Share (Detail) link:presentationLink link:calculationLink link:definitionLink 100430 - Disclosure - Earnings (Loss) per Share - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100440 - Disclosure - Significant Agreements - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100450 - Disclosure - Property and Equipment, Net - Property and Equipment, Net (Detail) link:presentationLink link:calculationLink link:definitionLink 100460 - Disclosure - Property and Equipment, Net - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100470 - Disclosure - Fair Value Measurements - Schedule of Fair Values of Financial Assets and Liabilities Measured at Fair Value (Detail) link:presentationLink link:calculationLink link:definitionLink 100480 - Disclosure - Fair Value Measurements - Significant Unobservable Inputs in the Fair Value Measurement (Detail) link:presentationLink link:calculationLink link:definitionLink 100490 - Disclosure - Fair Value Measurements - Summary of Fair Value (Detail) link:presentationLink link:calculationLink link:definitionLink 100500 - Disclosure - Fair Value Measurements - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100510 - Disclosure - Fair Value Measurements - Summary of Available-for-Sale Securities (Detail) link:presentationLink link:calculationLink link:definitionLink 100520 - Disclosure - Prepaid Expenses and Other Current Assets - Schedule of Prepaid Expenses and Other Current Assets (Detail) link:presentationLink link:calculationLink link:definitionLink 100530 - Disclosure - Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) link:presentationLink link:calculationLink link:definitionLink 100540 - Disclosure - Common Stock - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100550 - Disclosure - Common Stock - Schedule of Common Stock Reserved for Future Issuance (Detail) link:presentationLink link:calculationLink link:definitionLink 100560 - Disclosure - Stock-Based Compensation - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100570 - Disclosure - Stock-Based Compensation - Share Based Compensation Expense Related to Issuance of Stock Option Awards to Employees and Non Employees Related to Employee Stock Purchase Plan (Detail) link:presentationLink link:calculationLink link:definitionLink 100580 - Disclosure - Stock-Based Compensation - Grant Date Fair Values of Options Issued to Employees and Non-employees Estimated Using Black-Scholes Option Pricing Model (Detail) link:presentationLink link:calculationLink link:definitionLink 100590 - Disclosure - Stock-Based Compensation - Summary of Company's Stock Option Activity (Detail) link:presentationLink link:calculationLink link:definitionLink 100600 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Units Activity (Detail) link:presentationLink link:calculationLink link:definitionLink 100610 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Units Activity (Parenthetical) (Details) link:presentationLink link:calculationLink link:definitionLink 100620 - Disclosure - Loan Payable - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100630 - Disclosure - Loan Payable - Summary of Maturities of Principal Obligations Under Long-term Debt (Detail) link:presentationLink link:calculationLink link:definitionLink 100640 - Disclosure - Income Taxes - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100650 - Disclosure - Income Taxes - Schedule of Reconciliation of Provision for Income Taxes Computed at Statutory Federal Income Tax Rate to Provision for Income Taxes (Detail) link:presentationLink link:calculationLink link:definitionLink 100660 - Disclosure - Income Taxes - Components of Deferred Tax (Detail) link:presentationLink link:calculationLink link:definitionLink 100670 - Disclosure - Income Taxes - Summary of Reconciliation of Company's Unrecognized Tax Benefits (Detail) link:presentationLink link:calculationLink link:definitionLink 100680 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 100690 - Disclosure - Supplemental Cash Flow Information - Supplemental Disclosures of Cash Flow (Detail) link:presentationLink link:calculationLink link:definitionLink