0001193125-26-076536 | 10-K | XBRL Viewer | Syndax Pharmaceuticals INC

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Leases - Summary of Future Minimum Lease Payments under Operating Leases (Detail) - USD ($) $ in Thousands	Dec. 31, 2025	Oct. 31, 2024
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
2026	$ 656
2027	676
2028	403
Thereafter	0
Total lease payments	1,735
Less: imputed interest	(214)
Total operating lease liability	$ 1,521	$ 1,500

Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (285,422)	$ (318,758)	$ (209,360)
Adjustments to reconcile net loss to net cash provided (used in) provided by operating activities:
Depreciation	6	8	12
Accretion of investments	(10,753)	(13,468)	(14,803)
Non-cash operating lease expense	946	989	739
Stock-based compensation	47,503	43,026	30,951
Amortization of debt issuance costs	228	30	0
Provision for credit losses	3,667	0	0
Inventory reserves	163	0	0
Changes in operating assets and liabilities:
Accounts receivable	(30,394)	(7,602)	0
Inventory	(32,091)	(366)	0
Prepaid expenses and other current assets	(14,542)	(8,393)	676
Collaboration (payable) receivable, net	(42,976)	11,999	10,706
Other receivable	(6,436)	(3,635)	0
Other assets	0	463	0
Accounts payable	4,954	1,665	5,611
Accrued expenses and other current liabilities	42,167	19,139	14,867
Net cash used in operating activities	(322,980)	(274,903)	(160,601)
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of property and equipment	(187)	0	0
Purchases of short and long-term investments	(195,807)	(557,052)	(354,606)
Proceeds from maturities of short-term investments	486,030	337,277	472,215
Net cash provided by (used in) investing activities	290,036	(219,775)	117,609
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from Purchase and Sale agreement, net	0	343,652	0
Proceeds from ESPP	1,538	1,715	910
Proceeds from stock option exercises	12,138	8,000	5,128
Net cash provided by financing activities	13,676	353,367	264,132
NET (DECREASE) INCREASE IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH	(19,268)	(141,311)	221,140
CASH, CASH EQUIVALENTS AND RESTRICTED CASH—beginning of year	154,300	295,611	74,471
CASH, CASH EQUIVALENTS AND RESTRICTED CASH—end of year	135,032	154,300	295,611
Cash and cash equivalents	134,930	154,083	295,394
Restricted cash	102	217	217
Supplemental Cash Flow Information [Abstract]
Issuance costs in accounts payable and accrued expenses	0	0	250
Lease assets recognized upon lease remeasurement	0	1,524	0
Follow-on Public Offerings [Member]
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from issuance of common stock in follow-on public stock offering, net	0	0	215,955
At-the-Market Offering [Member]
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from issuance of common stock in follow-on public stock offering, net	$ 0	$ 0	$ 42,139

Stock-Based Compensation - Summary of Restricted Stock Units Activity (Detail) - Non-Vested Restricted Stock Units (RSUs) [Member]

12 Months Ended

Dec. 31, 2025

$ / shares

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Number of Shares, Unvested - December 31, 2024 | shares

1,304,087

Number of Shares, Granted | shares

2,001,335

^[1]

Number of Shares, Vested | shares

(410,707)

Number of Shares, Cancelled/Forfeited | shares

(277,153)

Number of Shares, Unvested - December 31, 2025 | shares

2,617,562

Weighted Average Grant Date Fair Value, Unvested - December 31, 2024 | $ / shares

$ 19.46

Weighted Average Grant Date Fair Value, Granted | $ / shares

13.37

^[1]

Weighted Average Grant Date Fair Value, Vested | $ / shares

21.31

Weighted Average Grant Date Fair Value, Cancelled/Forfeited | $ / shares

15.13

Weighted Average Grant Date Fair Value, Unvested - December 31, 2025 | $ / shares

$ 16.22

[1]	RSUs granted in 2025 and 2024 had a weighted average grant date fair value of $13.37 and $18.80, respectively. The fair values of RSUs vested in 2025 and 2024 totaled $8.8 million and $1.8 million, respectively.

Purchase and Sale Agreement - Schedule of Term Loan Payables (Details) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Purchase and Sale Agreement [Abstract]
Current portion of royalty interest financing	$ 0	$ 12,116
Royalty interest financing, less current portion	350,000	337,884
Debt issuance costs	(6,091)	(6,319)
Royalty interest financing, net	$ 343,909	$ 343,681

Basis of Presentation

12 Months Ended

Dec. 31, 2025

Accounting Policies [Abstract]

Basis of Presentation

2. Basis of Presentation

The Company has prepared the accompanying consolidated financial statements in conformity with accounting principles generally accepted in the United States of America or U.S. GAAP.

Certain prior amounts reported in the accompanying consolidated financial statements and notes thereto have been reclassified to conform to the current year presentation. Specifically, the change in royalty payable presented within the consolidated balance sheet for the period ended December 31, 2024, of $0.3 million was originally reported within the caption royalty payable and had been separately presented in the comparative presentation. For the period ended December 31, 2025, the royalties payable to AbbVie and UCB, based on net sales of Revuforj and Niktimvo, respectively, is included in accrued expenses and other current liabilities. Additionally, the interest expense recognized as part of the Royalty Pharma Purchase and Sale Agreement is presented separately on the consolidated statement of operations. For the period ended December 31, 2024, this expense was reported within interest expense. Such reclassification did not affect loss from operations, total assets, total liabilities, cash used in operations, or net loss.

In 2011, the Company established a wholly-owned subsidiary in the United Kingdom, which the Company dissolved in June 2024. In 2014, the Company established a wholly-owned U.S. subsidiary, which the Company dissolved in July 2025. In 2021, the Company established a wholly-owned subsidiary in the Netherlands. To date, there have been no material activities for these entities. All intercompany balances and transactions have been eliminated in consolidation.

Common Stock - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Millions		1 Months Ended			12 Months Ended
	Jan. 24, 2023	Dec. 31, 2023	May 31, 2023	Dec. 31, 2021	Dec. 31, 2023	Dec. 31, 2025	Dec. 31, 2024	May 09, 2023	Apr. 12, 2023	Mar. 08, 2016
Class Of Stock [Line Items]
Common stock, shares authorized						200,000,000	200,000,000
Proceeds from issuance of common stock in follow-on public stock offering, net				$ 81.2
Common stock, new shares issued	86,000	12,432,431		3,802,144
Shares available for issuance						30,335,981
Number Of Pre Funded Warrants Exercised For Common Stock	85,998							498,137	272,996
Offering price		$ 18.5
Gross proceeds from offering		$ 230.0
Common stock, par value						$ 0.0001	$ 0.0001
Incyte Collaboration Agreement and Share Purchase Agreement [Member]
Class Of Stock [Line Items]
Common stock issued at fair value					$ 14.0
Common stock issuable under pre-funded warrants
Class Of Stock [Line Items]
Shares available for issuance						285,714			273,000
Number Of Pre Funded Warrants Exercised For Common Stock								498,142
Warrants issued (in shares)				1,142,856
Offering price				$ 17.4999
Series Warrants [Member]
Class Of Stock [Line Items]
Offering price				$ 17.5
At The Market Equity Offering Sales Agreement [Member]
Class Of Stock [Line Items]
Proceeds from issuance of common stock in follow-on public stock offering, net					$ 42.1
Common stock, new shares issued					2,719,744
Cowen and Company LLC [Member] \| At The Market Equity Offering Sales Agreement [Member]
Class Of Stock [Line Items]
Proceeds from issuance of common stock in follow-on public stock offering, net			$ 200.0
Initial Public Offering [Member]
Class Of Stock [Line Items]
Common stock, shares authorized										200,000,000

Fair Value Measurements

12 Months Ended

Dec. 31, 2025

Fair Value Disclosures [Abstract]

Fair Value Measurements

11. Fair Value Measurements

The carrying amounts of cash and cash equivalents, restricted cash, accounts payable, and accrued expenses approximated their estimated fair values due to the short-term nature of these financial instruments. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value are performed in a manner to maximize the use of observable inputs and minimize the use of unobservable inputs.

The accounting standard describes a fair value hierarchy based on three levels of inputs, of which the first two are considered observable and the last unobservable, that may be used to measure fair value, which are the following:

Level 1—Quoted prices (unadjusted) in active markets that are accessible at the market date for identical unrestricted assets or liabilities.

Level 2—Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs for which all significant inputs are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

The table below presents information about the Company’s assets and liabilities that are regularly measured and carried at fair value and indicate the level within the fair value hierarchy of valuation techniques the Company utilized to determine such fair values (in thousands):


			Fair Value Measurements Using
	Total Carrying Value		Quoted Prices in Active Markets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
December 31, 2025
Assets:
Cash equivalents	$	115,358	$	115,358	$	—	$	—
Short-term investments		259,140		—		259,140		—
Long-term investments		—		—		—		—
Total assets	$	374,498	$	115,358	$	259,140	$	—


December 31, 2024
Assets:
Cash equivalents	$	154,083	$	129,187	$	24,896	$	—
Short-term investments		418,801		—		418,801		—
Long-term investments		119,520		—		119,520		—
Total assets	$	692,404	$	129,187	$	563,217	$	—

There have been no material impairments of our assets measured and carried at fair value during the years ended December 31, 2025, and 2024. In addition, there have been no changes in valuation techniques during the years ended December 31, 2025, and 2024. The fair value of Level 1 instruments classified as cash equivalents are valued using quoted market prices in active markets. The fair value of Level 2 instruments classified as cash equivalents, short- and long-term investments and Royalty interest financing was determined other than quoted prices in active markets, which are either directly or indirectly observable as of the reporting date and fair value is determined using models or other valuation methodologies.

The short- and long-term investments are classified as available-for-sale securities. As of December 31, 2025, the remaining contractual maturities of the available-for-sale securities were 1 to 12 months, and the balance in the Company’s accumulated other comprehensive income was comprised solely of activity related to the Company’s available-for-sale securities. There were no realized gains or losses recognized on the sale or maturity of available-for-sale securities during the three years ended December 31, 2025. As a result, the Company did not reclassify any amounts out of accumulated other comprehensive income for the same periods. The Company has a limited number of available-for-sale securities in insignificant loss positions as of December 31, 2025, which the Company does not intend to sell and has concluded will not be required to sell before recovery of the amortized cost for the investment at maturity.

The following table summarizes the available-for-sale securities (in thousands):


	Amortized Cost		Unrealized Gains		Unrealized (Losses)			Fair Value
December 31, 2025
Commercial paper	$	86,066	$	15	$	—		$	86,081
Corporate bonds		28,227		30		—			28,257
US Treasury		144,395		407		—			144,802
	$	258,688	$	452	$	—		$	259,140
December 31, 2024
Commercial paper	$	263,952	$	—	$	(56	)	$	263,896
Corporate bonds		40,261		—		—			40,261
US Treasury		233,945		219		—			234,164
	$	538,158	$	219	$	(56	)	$	538,321

Stock-Based Compensation - Grant Date Fair Values of Options Issued to Employees and Non-employees Estimated Using Black-Scholes Option Pricing Model (Detail)	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions and Methodology [Abstract]
Expected term (in years)	6 years 3 days	6 years 18 days	6 years 10 days
Volatility rate	68.01%	71.64%	75.13%
Risk-free interest rate	4.08%	4.15%	3.65%
Expected dividend yield	0.00%	0.00%	0.00%

Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2025

Share-Based Payment Arrangement [Abstract]

Share Based Compensation Expense Related to Issuance of Stock Option Awards to Employees and Non Employees Related to Employee Stock Purchase Plan

The Company recognized stock-based compensation expense related to the issuance of stock option awards to employees and non-employees and related to the Employee Stock Purchase Plan in the consolidated statements of operations as follows (in thousands):


	Years Ended December 31,
	2025		2024		2023
Research and development	$	16,032	$	19,934	$	14,147
Selling, general and administrative	$	31,471		23,092		16,804
Total	$	47,503	$	43,026	$	30,951

Grant Date Fair Values of Options Issued to Employees and Non-employees Estimated Using Black-Scholes Option Pricing Model

The grant date fair values of options issued to employees and non-employees were estimated using the Black-Scholes option-pricing model with the following assumptions:


	Years Ended December 31,
	2025			2024			2023
Expected term (in years)		6.01			6.05			6.03
Volatility rate		68.01	%		71.64	%		75.13	%
Risk-free interest rate		4.08	%		4.15	%		3.65	%
Expected dividend yield		0.00	%		0.00	%		0.00	%

Summary of Employee and Non-Employee Option Activity

A summary of employee and non-employee option activity under the Company’s equity award plans is presented below (in thousands, except share data):


	Number of Options			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (in years)		Aggregate Intrinsic Value
Outstanding—January 1, 2025		11,688,079		$	18.63		6.6	$	9,746
Granted		3,976,819		$	13.64
Exercised		(1,135,977	)	$	10.67
Cancelled, forfeited or expired		(1,400,615	)	$	19.62
Outstanding—December 31, 2025		13,128,306		$	17.74		7.0	$	56,881
Exercisable—December 31, 2025		7,525,866					5.6	$	30,174

Summary of Restricted Stock Units Activity

The following table summarizes our RSU activity:


	Number of Shares			Weighted Average Grant Date Fair Value
Unvested—December 31, 2024		1,304,087		$	19.46
Granted (1)		2,001,335		$	13.37
Vested		(410,707	)	$	21.31
Cancelled/Forfeited		(277,153	)	$	15.13
Unvested—December 31, 2025		2,617,562		$	16.22

(1) RSUs granted in 2025 and 2024 had a weighted average grant date fair value of $13.37 and $18.80, respectively. The fair values of RSUs vested in 2025 and 2024 totaled $8.8 million and $1.8 million, respectively.

Summary of Significant Accounting Policies - Additional Information (Detail)	3 Months Ended	12 Months Ended
	Dec. 31, 2025 USD ($) Claim	Dec. 31, 2025 USD ($) Segment Claim	Dec. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)
Summary Of Significant Accounting Policies [Line Items]
Number of operating segments \| Segment		1
Allowance for credit losses	$ 0	$ 0	$ 0
Commercial milestone expense	10,000,000
Net Sales	$ 150,000,000	150,000,000
Impairment charge		0
Advertising Expense		$ 14,400,000	$ 7,300,000	$ 6,100,000
Customer Concentration Risk Member \| Accounts Receivable [Member] \| Four Customer [Member]
Summary Of Significant Accounting Policies [Line Items]
Customers represented percentage		92.00%
Customer Concentration Risk Member \| Accounts Receivable [Member] \| Five Customer [Member]
Summary Of Significant Accounting Policies [Line Items]
Customers represented percentage			100.00%
Guarantees and Indemnifications [Member]
Summary Of Significant Accounting Policies [Line Items]
Indemnification obligations, claims outstanding \| Claim	0	0
Indemnification obligations claims, reserves established		$ 0
Minimum [Member]
Summary Of Significant Accounting Policies [Line Items]
Estimated useful lives	3 years	3 years
Percentage of income tax contingency realized		50.00%
Maximum [Member]
Summary Of Significant Accounting Policies [Line Items]
Estimated useful lives	5 years	5 years

Inventory - Schedule of consisted inventries (Details) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Inventory, Finished Goods and Work in Process, Gross [Abstract]
Raw materials	$ 29,027	$ 0
Work-in-process	2,112	330
Finished goods	1,615	36
Total Inventory	$ 32,754	$ 366

Cybersecurity Risk Management, Strategy, and Governance	12 Months Ended
Cybersecurity Risk Management, Strategy, and Governance	Dec. 31, 2025
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]	Item 1C. Cyber Security Risk Management and Strategy We have implemented and maintain various information security processes designed to identify, assess and manage material risks from cybersecurity threats to our critical computer networks, third-party hosted services, communications systems, hardware and software, and our critical data, including intellectual property, confidential information that is proprietary, strategic or competitive in nature, and our clinical trial and related data, or Information Systems and Data. Our information security function, which is led by our Vice President of Information Technology, or VP of IT, helps identify, assess and manage our cybersecurity threats and risks. The information security function identifies and assesses cybersecurity threats and risks by monitoring and evaluating our threat environment and our risk profile using various methods including, for example: manual and automated tools, subscribing to reports and services that identify cybersecurity threats, analyzing reports of threats, evaluating threats reported to us, internal and external audits, leveraging third party threat assessments, conducting vulnerability identification assessments, and leveraging external threat intelligence. Depending on the environment or system, we implement and maintain various technical, physical, and organizational measures, processes, standards and policies designed to manage and mitigate material risks from cybersecurity threats to our Information Systems and Data, including, for example: incident detection and response, disaster recovery and business continuity plans, encryption of certain data, network security controls, data segregation for certain data, access controls, physical controls, systems monitoring, penetration testing, and cybersecurity insurance. Certain information about our assessment and management of material risks from cybersecurity threats is included in risk management reports as applicable to senior leadership and the audit committee. We use third-party service providers to assist us from time to time to identify, assess, and manage material risks from cybersecurity threats, including, for example: cybersecurity consultants, managed cybersecurity service providers, and professional service firms, including legal counsel, forensic investigators, and penetration testing service providers. We also use third-party service providers to perform a variety of functions throughout our business, such as software-as-a-service providers, hosting companies, supply chain resources, contract research organizations, and contract manufacturing organizations. Depending on the nature of the services provided, the sensitivity of the critical systems, information and assets at issue, and the identity of the provider, we may conduct a review of security assessments provided by the vendor and impose contractual obligations related to cybersecurity on the vendor. For a description of the risks from cybersecurity threats that may materially affect the Company and how they may do so, see our risk factors under Part 1. Item 1A. “Risk Factors” in this Annual Report, including “If our information technology systems or those of third parties with whom we work, or our data are or were compromised, we could experience adverse consequences resulting from such compromise, including but not limited to regulatory investigations or actions; fines and penalties; disruptions of our business operations; reputational harm; loss of revenue or profits; and other adverse consequences.” Governance Our board of directors addresses the Company’s cybersecurity risk management as part of its general oversight function. Our board of directors’ audit committee is responsible for overseeing the Company’s cybersecurity risk management processes. Our cybersecurity risk assessment and management processes are implemented and maintained by certain Company management, including our VP of IT, who has over 25 years of experience in information technology including IT leadership in Department of Defense Research. Our VP of IT who reports to our Chief Financial Officer, or CFO, who has 23 years of experience as a CFO, including supervisory responsibility over IT and cybersecurity functions. Our VP of IT is responsible for hiring appropriate personnel, helping to integrate cybersecurity risk considerations into the Company’s overall risk management strategy, and communicating key priorities to relevant personnel. Our VP of IT is also responsible for approving budgets, helping prepare for cybersecurity incidents, approving cybersecurity processes, and reviewing security assessments and other security-related reports. Our cybersecurity incident processes are designed to escalate certain cybersecurity incidents to members of management depending on the circumstances, including our CFO, General Counsel, or GC, and Chief Executive Officer, or CEO. Our GC, CFO, and other leadership personnel work with our incident response team to help assess impact and mitigate and remediate cybersecurity incidents of which they are notified, in addition to notifying the audit committee of our board of directors, as appropriate. Our board of directors’ audit committee receives annual reports from our CFO concerning our significant cybersecurity threats and risk and the processes the Company has implemented to address them. Our audit committee also has access to various reports, summaries or presentations related to cybersecurity threats, risk and mitigation.
Cybersecurity Risk Management Processes Integrated [Flag]	true
Cybersecurity Risk Management Processes Integrated [Text Block]	Our information security function, which is led by our Vice President of Information Technology, or VP of IT, helps identify, assess and manage our cybersecurity threats and risks. The information security function identifies and assesses cybersecurity threats and risks by monitoring and evaluating our threat environment and our risk profile using various methods including, for example: manual and automated tools, subscribing to reports and services that identify cybersecurity threats, analyzing reports of threats, evaluating threats reported to us, internal and external audits, leveraging third party threat assessments, conducting vulnerability identification assessments, and leveraging external threat intelligence.
Cybersecurity Risk Management Third Party Engaged [Flag]	true
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]	true
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]	false
Cybersecurity Risk Board of Directors Oversight [Text Block]	Our board of directors addresses the Company’s cybersecurity risk management as part of its general oversight function. Our board of directors’ audit committee is responsible for overseeing the Company’s cybersecurity risk management processes. Our cybersecurity risk assessment and management processes are implemented and maintained by certain Company management, including our VP of IT, who has over 25 years of experience in information technology including IT leadership in Department of Defense Research. Our VP of IT who reports to our Chief Financial Officer, or CFO, who has 23 years of experience as a CFO, including supervisory responsibility over IT and cybersecurity functions. Our VP of IT is responsible for hiring appropriate personnel, helping to integrate cybersecurity risk considerations into the Company’s overall risk management strategy, and communicating key priorities to relevant personnel. Our VP of IT is also responsible for approving budgets, helping prepare for cybersecurity incidents, approving cybersecurity processes, and reviewing security assessments and other security-related reports. Our cybersecurity incident processes are designed to escalate certain cybersecurity incidents to members of management depending on the circumstances, including our CFO, General Counsel, or GC, and Chief Executive Officer, or CEO. Our GC, CFO, and other leadership personnel work with our incident response team to help assess impact and mitigate and remediate cybersecurity incidents of which they are notified, in addition to notifying the audit committee of our board of directors, as appropriate. Our board of directors’ audit committee receives annual reports from our CFO concerning our significant cybersecurity threats and risk and the processes the Company has implemented to address them. Our audit committee also has access to various reports, summaries or presentations related to cybersecurity threats, risk and mitigation.
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]	Our board of directors’ audit committee is responsible for overseeing the Company’s cybersecurity risk management processes.
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]	Our board of directors’ audit committee receives annual reports from our CFO concerning our significant cybersecurity threats and risk and the processes the Company has implemented to address them.
Cybersecurity Risk Role of Management [Text Block]	Our cybersecurity incident processes are designed to escalate certain cybersecurity incidents to members of management depending on the circumstances, including our CFO, General Counsel, or GC, and Chief Executive Officer, or CEO. Our GC, CFO, and other leadership personnel work with our incident response team to help assess impact and mitigate and remediate cybersecurity incidents of which they are notified, in addition to notifying the audit committee of our board of directors, as appropriate. Our board of directors’ audit committee receives annual reports from our CFO concerning our significant cybersecurity threats and risk and the processes the Company has implemented to address them. Our audit committee also has access to various reports, summaries or presentations related to cybersecurity threats, risk and mitigation.
Cybersecurity Risk Management Positions or Committees Responsible [Flag]	true
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]	Our VP of IT is responsible for hiring appropriate personnel, helping to integrate cybersecurity risk considerations into the Company’s overall risk management strategy, and communicating key priorities to relevant personnel. Our VP of IT is also responsible for approving budgets, helping prepare for cybersecurity incidents, approving cybersecurity processes, and reviewing security assessments and other security-related reports.
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]	Our cybersecurity risk assessment and management processes are implemented and maintained by certain Company management, including our VP of IT, who has over 25 years of experience in information technology including IT leadership in Department of Defense Research. Our VP of IT who reports to our Chief Financial Officer, or CFO, who has 23 years of experience as a CFO, including supervisory responsibility over IT and cybersecurity functions.
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]	Our audit committee also has access to various reports, summaries or presentations related to cybersecurity threats, risk and mitigation.

Property and Equipment, net (Tables)

12 Months Ended

Dec. 31, 2025

Property, Plant and Equipment [Abstract]

Property and Equipment, Net

Property and equipment, net, consisted of the following (in thousands):


	December 31,
	2025			2024
Equipment	$	271		$	84
Leasehold improvements		167			167
Furniture and fixtures		134			134
Office and computer equipment		34			34
Total property and equipment		606			419
Accumulated depreciation		(425	)		(419	)
Property and equipment, net	$	181		$	—

Income Taxes (Tables)

12 Months Ended

Dec. 31, 2025

Income Tax Disclosure [Abstract]

Schedule of Reconciliation of Provision for Income Taxes Computed at Statutory Federal Income Tax Rate to Provision for Income Taxes

Reconciliation of the differences between the effective income tax rate and federal statutory rate for the year ended December 31, 2025 (in thousands):


	Amount			Percent
Income tax computed at federal statutory rate	$	(59,830	)		21.0		%
State taxes, net of federal benefit		342			(0.1	)
Tax Credits
Research and development		2,529			(0.9	)
Orphan drug		(26,991	)		9.5
Nontaxable or Nondeductible items
Stock option deduction		3,060			(1.1	)
Non-deductible officer compensation		3,234			(1.1	)
Other		202			(0.1	)
Other Adjustments
Other		363			(0.1	)
Change in valuation allowance		77,524			(27.3	)
Effective tax rate	$	433			(0.2	)	%


	Years Ended December 31,
	2024			2023
Income tax computed at federal statutory rate		21.0	%		21.0	%
State taxes, net of federal benefit		-0.1	%		13.2	%
General business credit carryovers		1.1	%		1.5	%
Non-deductible expenses		-1.0	%		-1.0	%
Change in valuation allowance		-17.3	%		-34.9	%
Return to provision true up		-3.8	%		0.0	%
Other		0.0	%		0.0	%
		-0.1	%		-0.2	%

Components of Deferred Tax

The significant components of the Company’s deferred tax are as follows (in thousands):


	Years Ended December 31,
	2025			2024
Deferred tax assets (liabilities):
Net operating loss carryforwards	$	135,517		$	43,362
Research and development credits		13,519			16,074
Orphan drug credits		26,991			—
Capitalized start-up and other costs		80,089			84,870
Capitalized research and development costs		59,475			97,780
Equity based compensation		15,348			13,687
Accruals		5,021			2,829
Disallowed interest		2,489			—
Other temporary differences		1,257			36
Deferred tax assets before valuation allowance		339,706			258,638
Valuation allowances		(339,706	)		(258,638	)
Net deferred tax assets	$	—		$	—

Schedule of Supplemental Disclosure of Cash Paid for Income Taxes (Net of Refunds Received)

Supplemental disclosure of cash paid during the period for income taxes (net of refunds received):


	Year Ended December 31,
	2025
Tennessee	$	0.07
New York		0.06
Massachusetts		0.01
Other		0.01
Total cash taxes paid, net of refunds received	$	0.15

Summary of Reconciliation of Company's Unrecognized Tax Benefits

A reconciliation of the Company’s unrecognized tax benefits is as follows (in thousands):


	Years Ended December 31,
	2025		2024		2023
Unrecognized tax benefit--beginning of year	$	143	$	143	$	143
Decreases related to prior period positions		—		—		—
Unrecognized tax benefit--end of year	$	143	$	143	$	143

Inventory (Tables)

12 Months Ended

Dec. 31, 2025

Inventory Disclosure [Abstract]

Schedule Of consisted inventroies

Inventory consisted of the following (in thousands):


	December 31,
	2025		2024
Raw materials	$	29,027	$	—
Work-in-process		2,112		330
Finished goods		1,615		36
Total Inventory	$	32,754	$	366

Income Taxes - Schedule of Supplemental Disclosure of Cash paid During the Period for Income Taxes (Net of Refunds Received) (Details)	12 Months Ended
	Dec. 31, 2025 USD ($)
Income Tax Paid, by Individual Jurisdiction [Line Items]
Total cash taxes paid, net of refunds received	$ 150
Tennessee
Income Tax Paid, by Individual Jurisdiction [Line Items]
Total cash taxes paid, net of refunds received	70.00
New York
Income Tax Paid, by Individual Jurisdiction [Line Items]
Total cash taxes paid, net of refunds received	60.00
Massachusetts
Income Tax Paid, by Individual Jurisdiction [Line Items]
Total cash taxes paid, net of refunds received	10.00
Other
Income Tax Paid, by Individual Jurisdiction [Line Items]
Total cash taxes paid, net of refunds received	$ 10.00

Property and Equipment, Net - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Property, Plant and Equipment [Abstract]
Depreciation expense	$ 6,000	$ 8,000

Consolidated Statements of Stockholders' Equity (Parenthetical) $ in Thousands	12 Months Ended
	Dec. 31, 2023 USD ($)
At-the-market, offering expenses	$ 1,086
Direct Placement Offering [Member]
Direct offering, offering expenses	$ 14,044

Summary of Significant Accounting Policies (Policies)	12 Months Ended
Summary of Significant Accounting Policies (Policies)	Dec. 31, 2025
Accounting Policies [Abstract]
Estimates	Estimates The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of costs and expenses during the reporting period. The Company bases estimates and assumptions on historical experience when available and on various factors that it believes to be reasonable under the circumstances. The Company evaluates its estimates and assumptions on an ongoing basis. The Company’s actual results may differ from these estimates under different assumptions or conditions. Estimates and assumptions about future events and their effects cannot be determined with certainty and therefore require the exercise of judgment. As of the date of issuance of these financial statements, the Company is not aware of any specific event or circumstance that would require the Company to update its estimates, assumptions and judgments or revise the carrying value of its assets or liabilities. These estimates may change as new events occur and additional information is obtained and are recognized in the consolidated financial statements as soon as they become known. Actual results could differ from those estimates and any such differences may be material to the Company’s consolidated financial statements.
Cash Equivalents	Cash Equivalents Cash equivalents include all highly liquid investments maturing within 90 days or less from the date of purchase. Cash equivalents include money market funds, corporate debt securities, U.S. government agency notes, and overnight deposits.
Restricted Cash	Restricted Cash The Company classifies as restricted cash all cash pledged as collateral to secure long-term obligations and all cash whose use is otherwise limited by contractual provisions. Amounts are reported as non-current unless restrictions are expected to be released in the next 12 months.
Marketable Securities	Marketable Securities All investments in marketable securities are classified as available-for-sale and are reported at fair value with unrealized gains and losses excluded from earnings and reported net of tax in accumulated other comprehensive income, which is a component of stockholders’ equity. Unrealized losses that are determined to be other-than-temporary, based on current and expected market conditions, are recognized in earnings. Declines in fair value determined to be credit related are charged to earnings. The cost of marketable securities sold is determined by the specific identification method.
Segment Reporting	Segment Reporting Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision maker, or CODM, or decision-making group, in making decisions regarding resource allocation and assessing performance. The CODM is the Company's Chief Executive Officer. The Company has one operating and reportable segment.
Concentrations of Credit Risk	Concentrations of Credit Risk Cash and cash equivalents, restricted cash, and short- and long-term investments are financial instruments that potentially subject the Company to concentrations of credit risk. Substantially all of the Company’s cash, cash equivalents, and short- and long-term investments were deposited in accounts at two financial institutions, and at times, such deposits may exceed federally insured limits. The Company has not experienced any losses in such accounts, and management believes that the Company is not exposed to significant credit risk due to the financial position of the depository institutions in which those deposits are held. The Company’s available-for-sale investments primarily consist of government money market funds, corporate debt securities, commercial paper, credit card asset-backed securities and overnight deposits and potentially subject the Company to concentrations of credit risk.
Customer and Supplier Concentration	Customer and Supplier Concentration The Company has exposure to credit risk in accounts receivable from sales of Revuforj. Revuforj is sold to Specialty Distributors and Specialty Pharmacies, who subsequently sell Revuforj to pharmacies, hospitals and other customers. Four customers represented 92% of the Company's accounts receivable and net product sales as of and for the year ended December 31, 2025. Five customers represented 100% of the Company's accounts receivable and net product sales as of and for the year ended December 31, 2024. The Company outsources the manufacturing of its products to contract manufacturers. In addition, the Company currently relies on a limited number of suppliers for the active pharmaceutical ingredients in its products. Accordingly, the Company has concentration risk associated with its commercial manufacturing.
Accounts Receivable	Accounts Receivable Accounts receivable primarily relates to amounts due from customers, which are typically due within 45 to 65 days. The Company analyzes accounts that are past due for collectability. To date, the Company has not experienced any credit losses with respect to the collection of its accounts receivable and has not recorded an allowance for credit losses as of December 31, 2025 and 2024. The Company has no financial instruments with off balance sheet risk of loss.
Inventory	Inventory Inventories are stated at the lower of cost or net realizable value. Costs of inventories, which include amounts related to materials and manufacturing overhead, are determined on a first-in, first-out basis. An assessment of the recoverability of capitalized inventory is performed during each reporting period and any excess and obsolete inventories are reserved for or written down to their estimated net realizable value in the period in which the impairment is first identified. The Company has recognized prepaid inventory within prepaid expenses and other current assets for the year ended December 31, 2025, representing the cost of goods purchased in advance from vendors, which will be recognized as inventory upon delivery and acceptance to the Company's designated location.
Property and Equipment	Property and Equipment Property and equipment are recorded at cost. Depreciation is recorded using the straight-line method over the estimated useful lives of the assets (three to five years). Assets under capital leases are amortized over the shorter of their useful lives or lease term using the straight-line method. Major replacements and improvements are capitalized, while general repairs and maintenance are expensed as incurred.
Impairment of Long-Lived Assets	Impairment of Long-Lived Assets Long-lived assets are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of the asset may not be recoverable. When such events occur, the Company compares the carrying amounts of the assets to their undiscounted expected future cash flows. If this comparison indicates that there is impairment, the amount of impairment is calculated as the difference between the carrying value and fair value. To date, no such impairments have been recognized.
Revenue Recognition	Revenue Recognition The Company recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration which we expect to receive in exchange for those goods or services. The Company recognize revenue following the five – step model prescribed under FASB Accounting Standards Codification (ASC 606), Revenue from Contracts with Customers: (i) identify contract(s) with customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) we satisfy the performance obligations. The Company only recognizes revenue when it is probable that it will collect the consideration to which it is entitled in exchange for the goods or services that will be transferred to the customer. Product Revenue: The Company sells Revuforj to specialty distributors and specialty pharmacies, or collectively, Customers. These Customers subsequently resell Revuforj to healthcare providers, patients and other pharmacies. In addition to agreements with Customers, the Company enters into arrangements with healthcare providers and payors that provide for government-mandated and/or privately-negotiated rebates, chargebacks and discounts for the purchase of Revuforj. The Company recognizes revenue from product sales at the point Customers obtain control of the product, which generally occurs upon delivery. The transaction price that is recognized as product revenue includes an estimate of variable consideration which is described below. Payment terms with Customers do not exceed one year and, therefore, the Company does not account for a financing component in its arrangements. The Company expenses incremental costs of obtaining a contract with a Customer (for example, sales commissions) when incurred as the period of benefit is less than one year. Shipping and handling costs for product shipments to Customers are recorded as selling, general and administrative expenses. Revenue from products is recognized at the estimated net sales price (transaction price), which includes estimates of variable consideration. The Company includes estimated amounts in the transaction price to the extent it is determined probable that a significant reversal of cumulative revenue recognized will not occur when the uncertainty associated with the variable consideration is resolved. The Company’s estimates of variable consideration and determination of whether to include estimated amounts in the transaction price are based largely on an assessment of its anticipated performance and all information (historical, current and forecasted) that is reasonably available. The components of the Company's variable consideration include the following: Provider Chargebacks and Discounts Chargebacks for fees and discounts to providers represent the estimated obligations resulting from contractual commitments to sell products to qualified healthcare providers at prices lower than the list prices charged to Customers who directly purchase the product from the Company. Customers charge the Company for the difference between what they pay for the product and the ultimate selling price to the qualified healthcare providers. These components of variable consideration are established in the same period that the related revenue is recognized, resulting in a reduction of product revenue and accounts receivable. These reserves are recorded as a reduction of revenue and accounts receivable in the period in which the related product revenue is recognized. Trade Discounts and Allowances The Company generally provides Customers with discounts that include incentive fees which are explicitly stated in the Company’s contracts. These discounts are recorded as a reduction of revenue and accounts receivable in the period in which the related product revenue is recognized. These reserves are recorded as a reduction of revenue and accounts receivable in the period in which the related product revenue is recognized. Product Returns Consistent with industry practice, the Company has a product returns policy that provides Customers a right of return for product purchased within a specified period prior to and subsequent to the product’s expiration date. The Company estimates the amount of its products that may be returned and presents this amount as a reduction of revenue in the period the related product revenue is recognized, in addition to establishing a current liability. The Company considers several factors in the estimation process, including expiration dates of product shipped to Customers, inventory levels within the distribution channel, product shelf life, prescription trends and other relevant factors. These reserves are recorded as a reduction of revenue in the period in which the related product revenue is recognized. Government Rebates The Company is subject to discount obligations under state Medicaid programs and Medicare. Reserves related to these discount obligations are recorded in the same period the related revenue is recognized, resulting in a reduction of product revenue and the establishment of a current liability. The Company’s liability for these rebates consists of estimates of claims for the current reporting period and estimated future claims that will be made for product that has been recognized as revenue but remains in the distribution channel inventories at the end of the reporting period. These reserves are recorded as a reduction of revenue in the period in which the related product revenue is recognized. Patient Assistance Other programs that the Company offers include voluntary co-pay patient assistance programs intended to provide financial assistance to eligible patients with prescription drug co-payments required by payors and coupon programs for cash payors. The calculation of the current liability for this assistance is based on an estimate of claims and the cost per claim that the Company expects to receive associated with product that has been recognized as revenue but remain as in the distribution channel inventories at the end of each reporting period. These reserves are recorded as a reduction of revenue in the period in which the related product revenue is recognized. Distribution and Other Fees We pay distribution and other fees to certain customers in connection with the sales of our products. We record distribution and other fees paid to our customers as a reduction of revenue, unless the payment is for a distinct good or service from the customer and we can reasonably estimate the fair value of the goods or services received. If both conditions are met, we record the consideration paid to the customer as an operating expense. These costs are typically known at the time of sale, resulting in minimal adjustments subsequent to the period of sale. These reserves are recorded as a reduction of revenue in the period in which the related product revenue is recognized. Development Milestone Payments: The Company evaluates whether milestones are considered probable of being reached and estimates the amount to be included in the transaction price using the most likely amount method. If it is probable that a significant revenue reversal would not occur, the associated milestone value is included in the transaction price. Milestone payments that are not within the control of the Company or the licensee, such as regulatory approvals, are generally not considered probable of being achieved until those approvals are received. The transaction price is then allocated to each performance obligation on a relative stand-alone selling price basis, for which the Company recognizes revenue as or when the performance obligations under the contract are satisfied. At the end of each subsequent reporting period, the Company re-evaluates the probability of achievement of such development milestones and any related constraint, and if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect license fees and earnings in the period of adjustment. Commercial Milestone Payments and Royalties: For arrangements that include sales-based royalties, including milestone payments based on the level of commercial sales, and the license is deemed to be the predominant item to which the royalties or commercial milestones relate, the Company will recognize revenue at the later of when the related sales occur or when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied). A $10.0 million commercial milestone expense was recognized as part of selling, general and administrative expenses in the fourth quarter of 2025 upon the achievement of $150.0 million of net sales of Niktimvo. When no performance obligations are required of the Company, or following the completion of the performance obligation period, such amounts are recognized as revenue upon transfer of control of the goods or services to the customer. Generally, all amounts received or due other than sales-based milestones and royalties are classified as license fees. Deferred revenue arises from amounts received in advance of the culmination of the earnings process and is recognized as revenue in future periods as performance obligations are satisfied. Deferred revenue expected to be recognized within the next twelve months is classified as a current liability. Upfront payment contract liabilities resulting from the Company’s license agreements do not represent a financing component as the payment is not financing the transfer of goods or services, and the technology underlying the licenses granted reflects research and development expenses already incurred by the Company. For additional information on our collaboration and license arrangements, please read Note 4, Collaborative Research and License Agreements, to these consolidated financial statements.
Advertising expenses	Advertising expenses The Company expenses the costs of advertising, including promotional expenses, as incurred. Advertising expenses were $14.4 million, $7.3 million, and $6.1 million for the years ended December 31, 2025, 2024, and 2023, respectively.
Research and Development	Research and Development Research and development costs are expensed as incurred. Research and development expenses include payroll and personnel expenses, consulting costs, external contract research and development expenses, and allocated overhead, including rent, equipment depreciation, and utilities. Research and development costs that are paid in advance of performance are capitalized as a prepaid expense and amortized over the service period as the services are provided. The Company expenses upfront license payments related to acquired technologies that have not yet reached technological feasibility and have no alternative future use. In instances where the Company enters into cost-sharing arrangements, all research and development costs reimbursed by the collaborators are accounted for as reductions to research and development expense. During the years ended December 31, 2025, 2024 and 2023 the Company has incurred external costs related to the Incyte cost-sharing collaboration.
Clinical Costs	Clinical Costs Clinical study and trial costs are a component of research and development expenses. The Company expenses clinical trial activities performed by third parties based on an evaluation of the progress to completion of specific contract tasks using data such as patient enrollment, clinical site activations, or other information provided to us by our vendors. Depending on the progression of the contract and timing of invoicing and payment the research and development expense can be an accrued expense or a prepaid expense. Prepaid clinical study and trial costs are included in short-term deposits on the accompanying consolidated balance sheet.
Income Taxes	Income Taxes The Company records deferred tax assets and liabilities for the expected future tax consequences of temporary differences between the Company’s financial statement carrying amounts and the tax bases of assets and liabilities and for loss and credit carryforwards using enacted tax rates expected to be in effect in the years in which the differences reverse. A valuation allowance is provided to reduce the net deferred tax assets to the amount that will more likely than not be realized. The Company determines whether it is more likely than not that a tax position will be sustained upon examination. If it is not more likely than not that a position will be sustained, none of the benefit attributable to the position is recognized. The tax benefit to be recognized for any tax position that meets the more-likely-than-not recognition threshold is calculated as the largest amount that is more than 50% likely of being realized upon resolution of the contingency. The Company accounts for interest and penalties related to uncertain tax positions as part of its provision for income taxes.
Guarantees and Indemnifications	Guarantees and Indemnifications As permitted under Delaware law, the Company indemnifies its officers, directors, and employees for certain events or occurrences that happen by reason of the relationship with, or position held at, the Company. The Company has standard indemnification arrangements under office leases (as described in Note 5, Leases to these consolidated financial statements) that require it to indemnify the landlord against all costs, expenses, fines, suits, claims, demands, liabilities, and actions directly resulting from any breach, violation, or nonperformance of any covenant or condition of the Company’s lease. Through December 31, 2025, the Company had not experienced any losses related to these indemnification obligations and no claims were outstanding. The Company does not expect significant claims related to these indemnification obligations, and consequently, concluded that the fair value of these obligations is negligible, and no related reserves were established.
Stock-Based Compensation	Stock-Based Compensation The Company accounts for all stock option awards granted to employees and non-employees using a fair value method. Stock-based compensation is measured at the grant date fair value of the stock option grants and is recognized over the requisite service period of the awards (usually the vesting period) on a straight-line basis. For equity awards that have a performance condition, the Company recognizes compensation expense based on its assessment of the probability that the performance condition will be achieved. The Company accounts for forfeitures as they occur.
(Loss) Earnings Per Share	(Loss) Earnings Per Share Basic earnings per share is computed by dividing undistributed net income attributable to the Company by the weighted-average number of common shares outstanding during the period. Diluted earnings per share is computed based on the treasury method by dividing net income by the weighted-average number of common shares outstanding during the period plus potentially dilutive common equivalent shares outstanding.
Recently Issued and Adopted Accounting Pronouncements	Recently Issued and Adopted Accounting Pronouncements From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board FASB or other accounting standard setting bodies that we adopt as of the specified effective date. Unless otherwise discussed below, we do not believe that the adoption of recently issued standards have or may have a material impact on our consolidated financial statements or disclosures. In December 2023, the FASB issued Accounting Standards Update (“ASU”) 2023-09, Improvements to Income Tax Disclosures (“ASU 2023-09”), which intends to enhance the transparency, as well as the usefulness, of income tax disclosures, primarily related to the rate reconciliation and income taxes paid. The Company has adopted the guidance relevant to ASU 2023-09 prospectively, expanding its applicable income tax disclosures. In November 2024, the FASB issued ASU 2024-03, Income Statement—Reporting Comprehensive Income—Expense Disaggregation Disclosures (Subtopic 220-40): Disaggregation of Income Statement Expenses (ASU “2024-03”). Among other items, the requirements include expanded disclosures around employee compensation and selling expenses. ASU 2024-03 will be effective for the Company for the year ending December 31, 2027. The Company is still evaluating the impact of this new guidance on its unaudited consolidated financial statements but expects the adoption to result in disclosure changes only.

Fair Value Measurements (Tables)

12 Months Ended

Dec. 31, 2025

Fair Value Disclosures [Abstract]

Schedule of Fair Values of Financial Assets and Liabilities Measured at Fair Value


			Fair Value Measurements Using
	Total Carrying Value		Quoted Prices in Active Markets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
December 31, 2025
Assets:
Cash equivalents	$	115,358	$	115,358	$	—	$	—
Short-term investments		259,140		—		259,140		—
Long-term investments		—		—		—		—
Total assets	$	374,498	$	115,358	$	259,140	$	—


December 31, 2024
Assets:
Cash equivalents	$	154,083	$	129,187	$	24,896	$	—
Short-term investments		418,801		—		418,801		—
Long-term investments		119,520		—		119,520		—
Total assets	$	692,404	$	129,187	$	563,217	$	—

Summary of Available-for-Sale Securities

The following table summarizes the available-for-sale securities (in thousands):


	Amortized Cost		Unrealized Gains		Unrealized (Losses)			Fair Value
December 31, 2025
Commercial paper	$	86,066	$	15	$	—		$	86,081
Corporate bonds		28,227		30		—			28,257
US Treasury		144,395		407		—			144,802
	$	258,688	$	452	$	—		$	259,140
December 31, 2024
Commercial paper	$	263,952	$	—	$	(56	)	$	263,896
Corporate bonds		40,261		—		—			40,261
US Treasury		233,945		219		—			234,164
	$	538,158	$	219	$	(56	)	$	538,321

- Definition

Tabular disclosure of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

+ References

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-Paragraph 3
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481800/320-10-50-3

+ Details

Segment Reporting - Schedule of Operating Financial Results (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Segment Reporting Information [Line Items]
Total Revenue	$ 172,352	$ 23,680	$ 0
Less: Significant and other segment expenses
Cost of product sales	6,970	826	0
Research and development expenses	258,784	241,647	163,032
Royalty interest expense	33,779	4,930	0
Net income	(285,422)	(318,758)	(209,360)
Biopharmaceutical Cancer Therapeutics [Member]
Segment Reporting Information [Line Items]
Total Revenue	172,352	23,680	0
Less: Significant and other segment expenses
Cost of product sales	6,970	826	0
Other R&D programs	4,154	2,564	5,441
Personnel cost and other expenses	77,887	61,602	47,208
Commercial related expenses	53,630	33,541	13,115
Personnel cost and other expenses	71,271	46,893	22,898
Other SG&A expenses	23,310	17,353	14,105
Stock-based compensation	47,503	43,026	30,951
Royalty interest expense	33,779	4,930	0
Interest (income) expense, net	(22,724)	(26,091)	(20,955)
Other expense, net	1,283	247	361
Net income	(285,422)	(318,758)	(209,360)
Revumenib-related costs [Member] \| Biopharmaceutical Cancer Therapeutics [Member]
Less: Significant and other segment expenses
Research and development expenses	112,422	107,909	64,122
Axatilimab-related costs [Member] \| Biopharmaceutical Cancer Therapeutics [Member]
Less: Significant and other segment expenses
Research and development expenses	$ 48,289	$ 49,638	$ 32,114

CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Statement of Comprehensive Income [Abstract]
Net loss	$ (285,422)	$ (318,758)	$ (209,360)
Other comprehensive income (loss):
Unrealized gain (loss) on marketable securities, net of tax	289	(55)	1,024
Comprehensive loss	$ (285,133)	$ (318,813)	$ (208,336)

- Definition

Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners.

+ References + Details

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

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+ Details

Segment Reporting

12 Months Ended

Dec. 31, 2025

Segment Reporting [Abstract]

Segment Reporting

19. Segment Reporting

The Company manages its business activities on a consolidated basis and operate as a single operating and reportable segment: Syndax Pharmaceuticals. The Company derives revenue in the United States through milestone revenue and product sales on the recently approved products, Revuforj and Niktimvo. The accounting policies of the segment are the same as those described in Note 3 – Summary of Significant Accounting Policies.

To assess performance, the Company's Chief Operating Decision Maker, or CODM, the Chief Executive Officer, or CEO, Michael Metzger, uses consolidated net loss as the segment's measure of segment profit or loss. The CODM uses net loss in the budget and forecasting process and considers budget-to actual variances on a quarterly bases when making decisions about the allocation of operating and capital resources.

The following table provides the operating financial results of our biopharmaceutical cancer therapeutics segment:


	Year Ended December 31,
	2025			2024			2023

Total Revenue	$	172,352		$	23,680		$	—
Less: Significant and other segment expenses
Cost of product sales		6,970			826			—
Research and development expenses
Revumenib-related costs		112,422			107,909			64,122
Axatilimab-related costs		48,289			49,638			32,114
Other R&D programs		4,154			2,564			5,441
Personnel cost and other expenses		77,887			61,602			47,208
General and administrative expenses
Commercial related expenses		53,630			33,541			13,115
Personnel cost and other expenses		71,271			46,893			22,898
Other SG&A expenses		23,310			17,353			14,105
Stock-based compensation		47,503			43,026			30,951
Royalty interest expense		33,779			4,930			—
Interest (income) expense, net		(22,724	)		(26,091	)		(20,955	)
Other expense, net		1,283			247			361
Segment net loss	$	(285,422	)	$	(318,758	)	$	(209,360	)

- Definition

The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments.

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+ Details

Loss per Share

12 Months Ended

Dec. 31, 2025

Earnings Per Share [Abstract]

Loss per Share

6. Loss per Share

Basic and diluted loss per share are calculated as follows (in 000s except share data):


	Years Ended December 31,
	2025			2024			2023
Numerator - basic and diluted:
Net loss - basic and diluted	$	(285,422	)	$	(318,758	)	$	(209,360	)
Net loss attributable to common stockholders - basic and diluted	$	(285,422	)	$	(318,758	)	$	(209,360	)
Denominator - basic and diluted:
Weighted-average common shares outstanding - basic and diluted		86,625,610			85,622,065			70,370,519

The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares outstanding because such securities have an antidilutive impact due to losses reported (in common stock equivalent shares, in 000s):


	December 31,
	2025		2024		2023
Options to purchase common		13,128		11,688		10,685
Non-vested RSUs		2,618		1,304		309
ESPP to purchase common stock		127		70		35

For additional information related to the Company's common stock see Note 14, Common Stock to these consolidated financial statements.

Stock-Based Compensation - Summary of Company's Stock Option Activity (Detail) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Share-Based Payment Arrangement, Disclosure [Abstract]
Outstanding - January 1, 2025	11,688,079
Number of Options, Granted	3,976,819
Number of Options, Exercised	(1,135,977)	(717,413)	(662,042)
Number of Options, Cancelled, forfeited or expired	(1,400,615)
Number of Options, Outstanding - December 31, 2025	13,128,306	11,688,079
Number of Options, Exercisable - December 31, 2025	7,525,866
Weighted Average Exercise Price, Outstanding - January 1, 2025	$ 18.63
Weighted Average Exercise Price, Granted	13.64
Weighted Average Exercise Price, Exercised	10.67
Weighted Average Exercise Price, Cancelled, forfeited or expired	19.62
Weighted Average Exercise Price, Outstanding - December 31, 2025	$ 17.74	$ 18.63
Weighted Average Remaining Contractual Term (in years), Outstanding - January 1, 2025	7 years	6 years 7 months 6 days
Weighted Average Remaining Contractual Term (in years), Exercisable - December 31, 2025	5 years 7 months 6 days
Weighted Average Remaining Contractual Term (in years), Outstanding - December 31, 2025	$ 56,881	$ 9,746
Aggregate Intrinsic Value, Exercisable - December 31, 2025	$ 30,174

Leases - Additional Information (Detail) $ in Thousands		1 Months Ended						12 Months Ended
Leases - Additional Information (Detail) $ in Thousands	Aug. 17, 2021 USD ($)	Oct. 31, 2024 USD ($)	May 31, 2023 USD ($) ft²	Aug. 31, 2022 USD ($)	Mar. 31, 2021	Sep. 30, 2016 ft²	Dec. 31, 2015 ft²	Dec. 31, 2025 USD ($)	Dec. 31, 2024 USD ($)	Feb. 28, 2021
Lessee Lease Description [Line Items]
Remaining lease term								32 months
Right-of-use asset, net		$ 1,500						$ 1,342	$ 2,022
Operating lease liabilities		$ 1,500						1,521
Operating lease expense								900
Lease payments								800
Future minimum lease payments under capital leases								$ 2,244	$ 9,435
Maximum [Member]
Lessee Lease Description [Line Items]
Operating lease discount rate								14.00%
Minimum [Member]
Lessee Lease Description [Line Items]
Operating lease discount rate								10.00%
Massachusetts
Lessee Lease Description [Line Items]
Operating lease term of contract						5 years
Area of leased property \| ft²						12,207
Lease Commencement Date	Mar. 01, 2022					Mar. 01, 2017
Lease payments	$ 1,600
Lessee, Operating Lease, Option to Extend								On August 17, 2021, the Company signed a 36-month extension to the lease for the Waltham, MA office with aggregate payments of $1.6 million, with a lease commencement date of March 1, 2022.
New York
Lessee Lease Description [Line Items]
Operating lease term of contract		36 months	27 months	36 years			62 months			18 months
Area of leased property \| ft²			12,217				4,039
Lease Commencement Date		Oct. 23, 2024	Jun. 01, 2023	Sep. 01, 2022	Mar. 01, 2021		Jan. 01, 2016
Lease payments		$ 2,500	$ 1,600	$ 700

Collaborative Research and License Agreements - Additional Information (Detail) - USD ($) $ in Thousands		1 Months Ended				3 Months Ended	12 Months Ended
	Jan. 24, 2023	Aug. 31, 2024	Dec. 31, 2023	Dec. 31, 2021	Sep. 30, 2021	Dec. 31, 2025	Dec. 31, 2025	Dec. 31, 2024	Apr. 30, 2024
Research And Development Arrangement Contract To Perform For Others [Line Items]
Proceeds from Incyte Share Purchase Agreement shares	86,000		12,432,431	3,802,144
Aggregate purchase price				$ 81,200
Other receivables, net						$ 6,404	$ 6,404	$ 3,635	$ 3,500
Net Sales						150,000	150,000
Incyte Agreement [Member]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Common stock issued at fair value				24,800
Common stock issued at fair value				24,800
Collaboration receivable, net						28,100	28,100
Collaboration expense due to counterparty						4,400	4,400
Other receivables, net						$ 5,000	$ 5,000
Milestone payment received		$ 12,500
Incyte Agreement [Member] \| Maximum [Member]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Potential milestone payments to be made				220,000
Commercialization milestones and tiered royalties				$ 230,000
Incyte Agreement [Member] \| Global and U.S. [Member]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Development costs associated with clinical trials					45.00%
Incyte Agreement [Member] \| Global and U.S. [Member] \| Incyte Corporation [Member]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Development costs associated with clinical trials					55.00%
Incyte Agreement [Member] \| Ex-U.S. Countries [Member]
Research And Development Arrangement Contract To Perform For Others [Line Items]
Development costs associated with clinical trials					100.00%

CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares	Dec. 31, 2025	Dec. 31, 2024
Statement of Financial Position [Abstract]
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, shares authorized	10,000,000	10,000,000
Preferred stock, shares outstanding	0	0
Common stock, par value	$ 0.0001	$ 0.0001
Common stock, shares authorized	200,000,000	200,000,000
Common stock, shares outstanding	87,405,979	85,694,443
Common Stock Shares Issued Not Disclosed	false	false

Significant Agreements

12 Months Ended

Dec. 31, 2025

Equity [Abstract]

Significant Agreements

7. Significant Agreements

Vitae Pharmaceuticals, Inc.

In October 2017, the Company entered into a license agreement, or the Vitae License Agreement, with Vitae Pharmaceuticals, Inc., a subsidiary of AbbVie, or AbbVie, under which Vitae granted the Company an exclusive, sublicensable, worldwide license to a portfolio of preclinical, orally available, small molecule inhibitors of the interaction of menin with Mixed Lineage Leukemia, or MLL, protein, or the Menin Assets. The Company made a nonrefundable upfront payment of $5.0 million to Vitae in the fourth quarter of 2017. Additionally, subject to the achievement of certain milestone events, the Company may be required to pay AbbVie up to $99.0 million in one-time development and regulatory milestone payments over the term of the Vitae License Agreement. In the event that the Company or any of its affiliates or sublicensees commercializes the Menin Assets, the Company will also be obligated to pay AbbVie low single to low double-digit percentage royalties on sales, subject to reduction in certain circumstances, as well as up to an aggregate of $70.0 million in potential one-time, sales-based milestone payments based on achievement of certain annual sales thresholds. Under certain circumstances, the Company may be required to share a percentage of non-royalty income from sublicensees, subject to certain deductions, with AbbVie. The Company is solely responsible for the development and commercialization of the Menin Assets. Each party may terminate the Vitae License Agreement for the other party’s uncured material breach or insolvency; and the Company may terminate the Vitae License Agreement at will at any time upon advance written notice to AbbVie. AbbVie may terminate the Vitae License Agreement if the Company or any of its affiliates or sublicensees institutes a legal challenge to the validity, enforceability, or patentability of the licensed patent rights. Unless terminated earlier in accordance with its terms, the Vitae License Agreement will continue on a country-by-country and product-by-product basis until the later of: (i) the expiration of all of the licensed patent rights in such country; (ii) the expiration of all regulatory exclusivity applicable to the product in such country; and (iii) 10 years from the date of the first commercial sale of the product in such country.

As of the date of the Vitae License Agreement, the asset acquired had no alternative future use nor had it reached a stage of technological feasibility. As the processes or activities that were acquired along with the license do not constitute a “business,” the transaction has been accounted for as an asset acquisition. As a result, in 2017, the upfront payment of $5.0 million was recorded as research and development expense in the consolidated statements of operations. Since the inception of the agreement, the Company achieved certain development and regulatory milestones resulting in $38.0 million in expense, which includes an $18.0 million milestone expense in 2024 and a $12.0 million expense in 2025, related to the submission of a supplemental New Drug Application, or sNDA, for Revuforj and the first United States sale of Revuforj in its second indication.

UCB Biopharma Sprl

In July 2016, the Company entered into a license agreement, or the UCB License Agreement, with UCB Biopharma Sprl, or UCB, under which UCB granted to the Company a worldwide, sublicensable, exclusive license to UCB6352, which the Company refers to as axatilimab, an Investigational New Drug Application-ready anti-CSF-1R monoclonal antibody. The Company made a nonrefundable upfront payment of $5.0 million to UCB in the third quarter of 2016. Additionally, subject to the achievement of certain milestone events, the Company may be required to pay UCB up to $119.5 million in one-time development and regulatory milestone payments over the term of the UCB License Agreement. In the event that the Company or any of its affiliates or sublicensees commercializes axatilimab, the Company will also be obligated to pay UCB low double-digit percentage royalties on sales, subject to reduction in certain circumstances, as well as up to an aggregate of $250.0 million in potential one-time, sales-based milestone payments based on achievement of certain annual sales thresholds. Under certain circumstances, the Company may be required to share a percentage of non-royalty income from sublicensees, subject to certain

deductions, with UCB. The Company will be solely responsible for the development and commercialization of axatilimab, except that UCB is performing a limited set of transitional chemistry, manufacturing and control tasks related to axatilimab. Each party may terminate the UCB License Agreement for the other party’s uncured material breach or insolvency; and the Company may terminate the UCB License Agreement at will at any time upon advance written notice to UCB. UCB may terminate the UCB License Agreement if the Company or any of its affiliates or sublicensees institutes a legal challenge to the validity, enforceability, or patentability of the licensed patent rights. Unless terminated earlier in accordance with its terms, the UCB License Agreement will continue on a country-by-country and product-by-product basis until the later of: (i) the expiration of all of the licensed patent rights in such country; (ii) the expiration of all regulatory exclusivity applicable to the product in such country; and (iii) 10 years from the date of the first commercial sale of the product in such country.

As of the date of the UCB License Agreement, the asset acquired had no alternative future use nor had it reached a stage of technological feasibility. As the processes or activities that were acquired along with the license do not constitute a “business,” the transaction has been accounted for as an asset acquisition. In connection with its most recent amendment of the UCB License Agreement, in the second quarter of 2022 the Company paid UCB $5.8 million, which was recognized as a milestone expense. Since the effective date of the license agreement, the Company achieved certain development and regulatory milestones and has recorded $41.0 million as research and development expense, which includes a $15.0 million milestone paid during the third quarter of 2024 upon the approval of Niktimvo, a $10 million milestone recognized in the first quarter of 2025 for the first patient dosed in a Phase III study with the compound in a combination with another agent. The Company has also recognized a $10.0 million commercial milestone expense in the fourth quarter of 2025 upon the achievement of $150.0 million net sales of Niktimvo.

Bayer Pharma AG (formerly known as Bayer Schering Pharma AG)

In March 2007, the Company entered into a license agreement, or the Bayer Agreement, with Bayer Schering Pharma AG, or Bayer, for a worldwide, exclusive license to develop and commercialize entinostat and any other products containing the same active ingredient. Under the terms of the Bayer Agreement, the Company paid a nonrefundable up-front license fee of $2.0 million and is responsible for the development and marketing of entinostat. The Company recorded the $2.0 million license fee as research and development expense during the year ended December 31, 2007, as it had no alternative future use. The Company will pay Bayer royalties on a sliding scale based on net sales, if any, and make future milestone payments to Bayer of up to $150.0 million in the event that certain specified development and regulatory goals and sales levels are achieved.

Purchase and Sale Agreement

12 Months Ended

Dec. 31, 2025

Purchase and Sale Agreement [Abstract]

Purchase and Sale Agreement

16. Purchase and Sale Agreement

On November 4, 2024, the Company entered into a Purchase and Sale Agreement, or the Purchase and Sale Agreement with Royalty Pharma Development Funding, LLC, or Royalty Pharma, pursuant to which Royalty Pharma purchased rights to certain revenue streams from net sales of products comprising or containing axatilimab (including Niktimvo™) by the Company, its affiliates and its licensees in the United States and its respective territories, districts, commonwealths and possessions (including Guam and Puerto Rico) in exchange for an upfront fee of $350.0 million.

Pursuant to the Purchase and Sale Agreement, Royalty Pharma purchased the right to receive a percentage of net sales equal to a royalty rate of 13.8% on quarterly net sales of Niktimvo in the United States and its respective territories; provided that the royalty rate is subject to certain adjustments based on future aggregate net sales of the Product in the Territory, or the Revenue Participation Right. Aggregate payments made to Royalty Pharma in respect of the Revenue Participation Right will be capped at $822.5 million, or the Royalty Cap.

The Purchase and Sale Agreement contains customary representations, warranties and indemnities of the Company and Royalty Pharma and customary covenants relating to the royalty payments, including the grant of a back-up security interest in the purchased royalties and certain assets related to the Product and restrictions on the incurrence of additional indebtedness and on the existence of liens on the Company’s assets related to the Product.

Upon a change of control, the Company will have the right, but not the obligation, to repurchase the Revenue Participation Right at a repurchase price set forth in the Purchase and Sale Agreement. In addition, the Purchase and Sale Agreement provides that if certain events of default occur, including certain bankruptcy events or certain termination events with respect to the Company’s license agreement with UCB Biopharma Srl, Royalty

Pharma may require the Company to repurchase Royalty Pharma’s interests in the Revenue Participation Right at a repurchase price equal to the Royalty Cap.

The Company assessed the Purchase and Sale Agreement and identified it as a sale of future revenue in the form of a debt instrument to be accounted for as debt under ASC 470. The Company has elected to use the prospective method in its calculation of its effective interest rate and will update this calculation quarterly when there are changes in the projected sales. The debt is allocated on the balance sheet as short term and long term. The short term portion represents the royalty payments owed over the next 12 months. The long term portion is recorded on the balance sheet as net of issuance costs. Issuance costs pursuance to the Purchase and Sale Agreement consisted primarily of bank and legal fees and totaled $6.3 million. These issuance costs were recorded as a direct deduction to the carrying amount of the liability and will be amortized under the effective interest method over the estimated period the liability will be repaid. As of December 31, 2025, the royalty interest financing balance is equal to its fair value, based on the adjusted quarterly interest rate calculation. The balance is a level 2 classified fair value. For the year ended December 31, 2025, the Company estimated an effective annual interest rate of approximately 13.02%. Over the course of the Purchase and Sale agreement, the annual interest rate will be affected by the amount and timing of net Niktimvo revenue recognized and change in timing of forecasted net Niktimvo revenue. On a quarterly basis, the Company reassesses the expected timing of the net Niktimvo revenue, recalculates the amortization and effective interest rate, and adjusts the accounting prospectively, as needed. The Company recognized interest expense of $33.8 million and $5.0 million in the years ended December 31, 2025, and 2024, respectively, related to the Purchase and Sale Agreement. The Company made $13.2 million of payments on the Purchase and Sale agreement during the year ended December 31, 2025.


	December 31,
	2025			2024
Current portion of royalty interest financing	$	-		$	12,116
Royalty interest financing, less current portion		350,000			337,884
Debt issuance costs		(6,091	)		(6,319	)
Royalty interest financing, net	$	343,909		$	343,681

Nature of Business

12 Months Ended

Dec. 31, 2025

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Nature of Business

1. Nature of Business

Syndax Pharmaceuticals, Inc., or the Company or Syndax, is a commercial-stage biopharmaceutical company developing an innovative pipeline of cancer therapies. The Company currently has two commercially approved medicines and a robust slate of clinical development programs.

Revuforj® (revumenib) is a first-in-class menin inhibitor that was FDA-approved in November 2024 for the treatment of relapsed or refractory, or R/R, acute leukemia with a lysine methyltransferase 2A gene, or KMT2A, translocation in adult and pediatric patients one year old and older. In October 2025, Revuforj received a second approval from the FDA for the treatment of R/R acute myeloid leukemia, or AML, with a susceptible nucleophosmin 1 mutation, or NPM1m, in adult and pediatric patients one year and older who have no satisfactory alternative treatment options. We are also studying revumenib in combination with standard-of-care agents in NPM1m AML or KMT2A acute leukemia across the treatment landscape, including in newly diagnosed patients. Additionally, we are exploring the potential for menin inhibition in myelofibrosis.

Niktimvo™ (axatilimab-csfr) is a first-in-class colony stimulating factor-1 receptor, or CSF-1R, blocking antibody that was FDA-approved in August 2024 for the treatment of chronic graft-versus-host disease, or cGVHD, after failure of at least two prior lines of systemic therapy in adult and pediatric patients weighing at least 40 kg. Axatilimab is in development for the treatment of newly diagnosed cGVHD patients in combination with standard of care therapies, as well for the treatment of idiopathic pulmonary fibrosis. The Company plans to continue to leverage the technical and business expertise of its management team and scientific collaborators to license, acquire and develop additional therapeutics to expand its pipeline.

The Company is subject to risks common to companies with newly approved products and robust ongoing clinical programs, including, but not limited to, successful commercialization of its medicines, successful development of additional therapeutics, obtaining additional funding, protection of proprietary therapeutics, compliance with government regulations, fluctuations in operating results, dependence on key personnel and collaborative partners, and risks associated with industry changes. The Company’s long-term success is dependent upon its ability to successfully market its current products, develop new product candidates, expand its oncology drug pipeline, earn revenue, obtain additional capital when needed, and ultimately, achieve profitable operations. Management expects to incur substantial losses on the ongoing development of its product candidates and the Company may not achieve positive cash flow from operations in the near future, if ever. As a result, the Company may continue to require additional capital to move forward with its business plan. While certain amounts of this additional capital were raised in the past, there can be no assurance that funds necessary beyond these amounts will be available in amounts or on terms sufficient to ensure ongoing operations.

The Company’s management believes that the cash, cash equivalents and short-term investments balances as of December 31, 2025, should enable the Company to maintain its planned operations for at least 12 months from the issuance date of these financial statements. The Company’s ability to fund all of its planned operations internally beyond that date, including the successful commercialization of its products and the completion of its ongoing and planned clinical trial activities, may be substantially dependent upon whether the Company can obtain sufficient funding on terms acceptable to the Company. Proceeds from additional capital transactions may allow the Company to accelerate and/or expand its planned research and development activities. In the event that sufficient funds were not available, the Company may be required to delay or reduce expenditures to conserve cash, which could involve scaling back or curtailing development and selling, general and administrative activities.

The Company is subject to challenges and risks specific to its business and ability to execute on the strategy, as well as risks and uncertainties common to companies in the pharmaceutical industry with development and commercial operations, including, without limitation, risks and uncertainties associated with: successfully launching the Company's products; obtaining regulatory approval for additional indications for the Company's products and product candidates; delays or problems in the supply of the Company’s products, loss of single source suppliers or failure to comply with manufacturing regulations; identifying, acquiring or in-licensing additional products or product candidates; pharmaceutical product development and the inherent uncertainty of clinical success; and the challenges of protecting and enhancing the Company’s intellectual property rights; complying with applicable regulatory requirements.

Property and Equipment, net

12 Months Ended

Dec. 31, 2025

Property, Plant and Equipment [Abstract]

Property and Equipment, net

10. Property and Equipment, net

Property and equipment, net, consisted of the following (in thousands):


	December 31,
	2025			2024
Equipment	$	271		$	84
Leasehold improvements		167			167
Furniture and fixtures		134			134
Office and computer equipment		34			34
Total property and equipment		606			419
Accumulated depreciation		(425	)		(419	)
Property and equipment, net	$	181		$	—

Depreciation expense was $6,000 and $8,000 for the years ended December 31, 2025 and 2024, respectively.

Property and Equipment, Net - Property and Equipment, Net (Detail) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Property Plant And Equipment [Line Items]
Property and equipment, gross	$ 606	$ 419
Accumulated depreciation	(425)	(419)
Property and equipment, net	181	0
Equipment [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	271	84
Leasehold Improvements [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	167	167
Furniture and Fixtures [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	134	134
Office and Computer Equipment [Member]
Property Plant And Equipment [Line Items]
Property and equipment, gross	$ 34	$ 34

Collaborative Research and License Agreements

12 Months Ended

Dec. 31, 2025

Research and Development [Abstract]

Collaborative Research and License Agreements

4. Collaborative Research and License Agreements

Incyte Collaboration

In September 2021, the Company entered into the Incyte License and Collaboration Agreement, or the Incyte License, with Incyte covering the worldwide development and commercialization of axatilimab. Also in September 2021, the Company entered into a share purchase agreement with Incyte, or the Incyte Share Purchase Agreement. These agreements are collectively referred to as the Incyte Agreements. Under the terms of the Incyte Agreements, Incyte received exclusive commercialization rights outside of the United States, subject to certain royalty payment obligations set forth below. In the United States, Incyte and the Company are co-commercializing axatilimab as Niktimvo™ (axatilimab-csfr), which was approved in August 2024. The Company and Incyte share equally the profits and losses from co-commercialization efforts in the United States.

Incyte is responsible for leading all aspects of commercialization of axatilimab in the United States. The Company and Incyte will share equally the profits and losses from co-commercialization efforts in the United States. The Company and Incyte have agreed to co-develop axatilimab and to share development costs associated with global and U.S. – specific clinical trials, with Incyte responsible for 55% of such costs and the Company responsible for 45% of such costs. Each company will be responsible for funding any of its own independent development activities. Incyte is responsible for 100% of future development costs for trials that are specific to non-U.S. countries. All development costs related to the collaboration with Incyte will be subject to a joint development plan.

Under the terms of the Incyte Agreements, the Company is eligible to receive up to $220.0 million in future contingent development and regulatory milestones and up to $230.0 million in commercialization milestones as well as tiered royalties ranging in the mid-teens percentage on net sales of the licensed product comprising axatilimab in Europe and Japan and low double digit percentage in the rest of the world outside of the United States. The Company's right to receive royalties in any particular country will expire upon the last to occur of (a) the expiration of licensed patent rights covering the licensed product in that particular country, (b) a specified period of time after the first post - marketing authorization sale of a licensed product in that country, and (c) the expiration of any regulatory exclusivity for that licensed product in that country.

The Incyte Agreement and the Incyte Share Purchase Agreement were executed on the same date and negotiated simultaneously. Management therefore concluded that the Incyte Agreements are to be combined for accounting purposes and therefore allocated the total consideration to the units of account identified. The common stock issued to Incyte was recorded at fair value of $24.8 million.

The Company evaluated the terms of the Incyte Agreement and determined it is within the scope of Accounting Standard Update 2018-18, Collaborative Arrangements (Topic 808), and has elements that are within the scope of Topic 606 and Topic 808.

The Company identified the following promises in the Incyte Agreements that were evaluated under the scope of Topic 606: (i) delivery of a license for axatilimab to develop, commercialize, and conduct medical affairs and (ii) services to be performed in accordance with the development plan. The Company also evaluated whether certain options outlined within the Incyte Agreements represented material rights that would give rise to a performance obligation and concluded that none of the options convey a material right to Incyte and therefore are not considered separate performance obligations within the Incyte Agreements.

The Company assessed the above promises and determined that the license for axatilimab represents the only performance obligation within the scope of Topic 606. The license for axatilimab is considered functional intellectual property and distinct from other promises under the contract as Incyte can benefit from the license on its own or together with other readily available resources. The license represents a separate performance obligation within a contract with a customer under the scope of Topic 606 at contract inception.

The Company considers the collaborative research and development activities and manufacturing activities to be separate units of account within the scope of Topic 808 and are not deliverables under Topic 606. The Company and Incyte are both active participants in the activities and are exposed to significant risks and rewards that are dependent on the commercial success of the activities in the arrangement.

The Company used the most likely amount method to estimate variable consideration and estimated that the most likely amount for each potential preclinical, development, and regulatory variable consideration milestone payment under this agreement is zero, as achievement of those milestones is uncertain and highly susceptible to factors outside the Company’s control. Accordingly, all such milestone payments were excluded from the transaction price. Management will reevaluate the transaction price at the end of each reporting period and as uncertain events are resolved or other changes in circumstances occur, will adjust the transaction price as necessary. Sales based royalties, including milestones based on the level of sales, were also excluded from the transaction price, as the license is deemed to be the predominant item to which the royalties relate. The Company will recognize such revenue at the later of (i) when the related sales occur, or (ii) when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied).

In August 2024, the U.S. Food and Drug Administration, or FDA, approved Niktimvo for the treatment of cGVHD after failure of at least two prior lines of systemic therapy in adult and pediatric patients weighing at least 40 kg (88.2 lbs). As a result of the approval of Niktimvo, the Company earned a revenue milestone of $12.5 million, which was received in the third quarter of 2024. A $5.0 million milestone receivable was recognized in the fourth quarter of 2025 upon the achievement of $150.0 million of net sales of Niktimvo.

As of December 31, 2025, the Company has recorded $28.1 million as a collaboration receivable due from Incyte related to the Company's portion of the profit share, commercialization and development costs under the Incyte Agreements and has recorded approximately $4.4 million as a collaboration payable due to Incyte for development and commercialization costs incurred by Incyte as of December 31, 2025.

Loan Payable - Summary of Maturities of Principal Obligations Under Long-term Debt (Detail) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Debt Disclosure [Abstract]
Current portion of term loan	$ 0	$ 12,116

Other Receivables, net (Additional Information) (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2025	Oct. 31, 2025	Dec. 31, 2024	Apr. 30, 2024
Other Receivables Net [Line Item]
Other receivables, net	$ 6,404	$ 6,404		$ 3,635	$ 3,500
Receivables with Eddingpharm	3,700	3,700
Fee refund received	1,300	1,300
Net Sales	150,000	150,000
License Agreement Terms [Member]
Other Receivables Net [Line Item]
Other receivables, net	$ 5,000	$ 5,000
Food and Drug Administration [Member]
Other Receivables Net [Line Item]
Drug fee paid			$ 1,300

Leases

12 Months Ended

Dec. 31, 2025

Lessee Disclosure [Abstract]

Leases

5. Leases

Leases

The Company accounts for leases in accordance with ASC 842, Leases, and determines whether an arrangement is a lease at inception. Operating lease right-of-use, or ROU, assets and lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at commencement date. Lease agreements with lease and non-lease components are accounted for separately. For leases that do not provide an implicit rate, the Company uses the incremental borrowing rate based on the information available at commencement date in determining the present value of future payments. The ROU asset also includes any lease payments made and excludes lease incentives and initial direct costs incurred. The lease terms may include options to extend or terminate the lease when it is reasonably certain that the Company will exercise that option. Leases with an initial term of 12 months or less are not recorded on the balance sheet as the Company has elected to apply the short-term lease exemption. Lease expense for minimum lease payments is recognized on a straight-line basis over the lease term.

The Company identified three existing building leases under ASC 842 that are classified as operating leases. In September 2016, the Company entered into a five-year operating lease for 12,207 square feet of office space in Waltham, MA, with a lease commencement date of March 1, 2017. On August 17, 2021, the Company signed a

36-month extension to the lease for the Waltham, MA office with aggregate payments of $1.6 million, with a lease commencement date of March 1, 2022. As of December 31, 2025, the lease term has ended.

In December 2015, the Company entered into a 62-month operating lease for 4,039 square feet of space in New York, NY, which commenced on January 1, 2016. In February 2021, the Company signed an 18-month extension to the lease for the New York office, which commenced on March 1, 2021. In August 2022, the Company signed a 36-month extension to the lease for the New York office, with aggregate payments of $0.7 million, with a lease commencement date of September 1, 2022. As of December 31, 2025, the lease term has ended.

In May 2023, the Company entered into a 27-month operating lease for an additional 12,217 square feet of space in New York, NY, with aggregate payments of $1.6 million, with a lease commencement date of June 1, 2023. In October 2024, the Company signed a 36-month extension to the lease for the New York office, with aggregate payments of $2.5 million, with a lease commencement date of October 23, 2024. The Company recognized $1.5 million of ROU asset and lease liability upon the remeasurement of the lease as a result of the extension. The remaining lease term as of December 31, 2025 was 32 months.

As of December 31, 2025, the consolidated balance sheet includes a $1.3 million operating lease ROU asset and a $1.5 million ROU liability. The Company used an incremental borrowing rate of 10%-14% to calculate its lease obligations, and an increase or decrease in the rate does not have a significant impact on the ROU asset or ROU liability. The ROU asset is amortized on a straight-line basis over the remainder of the lease term. For the year ended December 31, 2025, the Company recorded approximately $0.9 million in operating lease expense and made approximately $0.8 million in lease payments.

Future minimum lease payments under the Company’s operating leases, were as follows:


Maturity of lease liabilities	As of
(in thousands)	December 31, 2025
2026		656
2027		676
2028		403
Thereafter		—
Total lease payments	$	1,735
Less: imputed interest		(214	)
Total operating lease liability	$	1,521

Future minimum lease payments under the Company’s capital leases as of December 31, 2025 and 2024, were $2,244 and $9,435, respectively.

Segment Reporting (Tables)

12 Months Ended

Dec. 31, 2025

Segment Reporting [Abstract]

Schedule of Operating Financial Results

The following table provides the operating financial results of our biopharmaceutical cancer therapeutics segment:


	Year Ended December 31,
	2025			2024			2023

Total Revenue	$	172,352		$	23,680		$	—
Less: Significant and other segment expenses
Cost of product sales		6,970			826			—
Research and development expenses
Revumenib-related costs		112,422			107,909			64,122
Axatilimab-related costs		48,289			49,638			32,114
Other R&D programs		4,154			2,564			5,441
Personnel cost and other expenses		77,887			61,602			47,208
General and administrative expenses
Commercial related expenses		53,630			33,541			13,115
Personnel cost and other expenses		71,271			46,893			22,898
Other SG&A expenses		23,310			17,353			14,105
Stock-based compensation		47,503			43,026			30,951
Royalty interest expense		33,779			4,930			—
Interest (income) expense, net		(22,724	)		(26,091	)		(20,955	)
Other expense, net		1,283			247			361
Segment net loss	$	(285,422	)	$	(318,758	)	$	(209,360	)

Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Income Taxes [Line Items]
Increase (decrease) in valuation allowance	$ 81,100	$ 52,700
Valuation allowance for deferred tax assets, description	The Company has provided a valuation allowance for the full amount of the net deferred tax assets as the realization of the deferred tax assets is not determined to be more likely than not. The valuation allowance increased by $81.1 million in 2025 due to the increase in deferred tax assets, primarily driven by the generation of net operating losses, and capitalized research expenses. The valuation allowance increased by $52.7 million in 2024 due to the increase in deferred tax assets, primarily driven by the generation of net operating losses and capitalized research expenses, and capitalized start-up costs.
Federal net operating losses	$ 585,300
State net operating losses	227,700
Internal Revenue Service [Member]
Income Taxes [Line Items]
Interest or penalties recorded during the period	0	0
Unrecognized income tax benefits that would affect effective tax rate	0
In Process Research and Development
Income Taxes [Line Items]
Increase (decrease) in valuation allowance	100	100
Federal [Member]
Income Taxes [Line Items]
Deferred tax assets research credits	9,800
Federal [Member] \| Indefinite Carryforward Period [Member]
Income Taxes [Line Items]
Federal net operating losses	563,200
Federal [Member] \| Begin to Expire in 2026 [Member]
Income Taxes [Line Items]
Federal net operating losses	22,100
State [Member]
Income Taxes [Line Items]
Current State Income Expense	$ 400	$ 300
Operating loss carryforward expiration period	2026
Deferred tax assets research credits	$ 27,000
Deferred tax assets research credits expiration period	2024
State [Member] \| Indefinite Carryforward Period [Member]
Income Taxes [Line Items]
State net operating losses	$ 8,700
State [Member] \| Begin to Expire in 2026 [Member]
Income Taxes [Line Items]
State net operating losses	$ 219,000

Other Receivables, net

12 Months Ended

Dec. 31, 2025

Other Receivables, Net, Current [Abstract]

Other Receivables, net

8. Other Receivables, net

In April 2024, entinostat received marketing approval in China, and as a result, the Company recorded $3.5 million of milestone revenue in 2024. As of December 31, 2025, the Company had recorded a $3.7 million receivable related to milestones (plus accrued interest) under the license, development, and commercialization agreement, or the Eddingpharm License Agreement, with Eddingpharm Investment Company Limited, or Eddingpharm. As the receivable remains outstanding and the Company has assessed the amount as non-recoverable, the Company has recorded a full reserve against the asset as a selling, general and administrative expense as of December 31, 2025.

In April 2025, the Company submitted an sNDA for Revuforj with the FDA. In October 2025, the Company paid a $1.3 million Prescription Drug User Fee Act (PDUFA) fee, while awaiting an FDA-decision on its submitted waiver of such fee. As Revuforj is an orphan drug, it is exempt from the PDUFA fee. As of December 2025, the Company has recorded a $1.3 million receivable for the fee refund, and in February 2026, the refund was received from the FDA.

In December 2025, the Company recorded $5.0 million of milestone revenue as a result of achieving $150.0 million of Niktimvo net sales. As of December 31, 2025, the Company had recorded $5.0 million in milestone receivable under the Incyte Collaboration and License Agreement.

Accrued Expenses and Other Current Liabilities

12 Months Ended

Dec. 31, 2025

Payables and Accruals [Abstract]

Accrued Expenses and Other Current Liabilities

13. Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consisted of the following (in thousands):


	December 31,
	2025		2024
Product revenue allowances	$	9,810	$	849
Accrued clinical study and trial costs		18,977		23,869
Accrued selling, general, and administrative costs		6,316		4,258
Accrued compensation and related costs		24,352		14,477
Accrued professional fees		-		385
Accrued milestone costs		10,000		10,600
Accrued royalty payable		7,372		307
Accrued interest - debt		25,516		4,930
Other		721		421
Total accrued expense and other current liabilities	$	103,064	$	60,096

Stock-Based Compensation

12 Months Ended

Dec. 31, 2025

Share-Based Payment Arrangement [Abstract]

Stock-Based Compensation

15. Stock-Based Compensation

In September 2015, the Company’s board of directors adopted its 2015 Omnibus Incentive Plan, or 2015 Plan, which was subsequently approved by its stockholders and became effective upon the closing of the IPO on March 8, 2016. The 2015 Plan replaced the 2007 Stock Plan, or 2007 Plan and allows for the granting of incentive stock options, nonqualified stock options, stock appreciation rights, restricted stock, unrestricted stock, stock units, dividend equivalent rights, performance awards, annual incentive awards, and other equity-based awards to the Company’s executives and other employees, non-employee members of the board of directors, and consultants of the Company. Any options or awards outstanding under the Company’s 2007 Plan remain outstanding and continue to govern the terms of any equity grants that remain outstanding under the 2007 Plan. Any shares of common stock related to awards outstanding under the 2007 Plan that thereafter terminate by expiration, forfeiture, cancellation or otherwise without the issuance of such shares will be added to, and included in, the 2015 Plan reserve amount. The Company initially reserved 1,750,000 shares of its common stock for the issuance of awards under the 2015 Plan. The 2015 Plan provides that the number of shares reserved and available for issuance under the 2015 Plan will automatically increase each January 1, beginning on January 1, 2017, by 4% of the outstanding number of shares of common stock on the immediately preceding December 31 or such lesser number of shares as determined by the Company’s board of directors. On January 1, 2026, the shares available for issuance under the 2015 Plan was increased to 3,496,239. The 2015 Plan will expire in March 2026.

In February 2023, the Company's board of directors adopted its 2023 Inducement Plan, or the 2023 Inducement Plan, which became effective March 1, 2023. The 2023 Inducement Plan allows for the granting of nonqualified stock options, restricted stock units, and other awards under the 2023 Inducement Plan to persons not previously an employee or director of the Company, or following a bona fide period of non-employment, an inducement material to such persons entering into employment with the Company. The Company initially reserved 1,900,000 shares of its common stock for the issuance of awards under the 2023 Inducement Plan. In December 2024 and 2023, the Company's board of directors approved the increase of the reserve by 1,200,000 and 1,100,000 shares respectively, effective the following year. There is no increase to the 2023 plan in January 2026.

As of December 31, 2025, there were 4,452,162 shares available for issuance under the 2015 Plan and 569,122 shares available for issuance under the 2023 Inducement Plan.


	Years Ended December 31,
	2025		2024		2023
Research and development	$	16,032	$	19,934	$	14,147
Selling, general and administrative	$	31,471		23,092		16,804
Total	$	47,503	$	43,026	$	30,951

Stock Options and Restricted Stock Units

As of December 31, 2025, there was $78.7 million of unrecognized compensation cost related to employee and non-employee unvested stock options and RSUs granted under the 2015 Plan and the 2023 Inducement Plan, which is expected to be recognized over a weighted-average remaining service period of 2.4 years. For the years ended December 31, 2025, and 2024, the Company capitalized $460 and $53 of stock compensation expense to inventory. There was no stock based compensation capitalized for the year ended December 31, 2023.

The Company's stock-based awards are subject to either service or performance-based vesting conditions. Compensation expense related to awards to employees, directors and non-employees with service-based vesting conditions is recognized on a straight-line basis based on the grant date fair value over the associated service period of the award, which is generally the vesting term. Compensation expense related to awards to employees with performance-based vesting conditions is recognized based on the grant date fair value over the requisite service period using the straight-line method to the extent achievement of the performance condition is probable.

In 2022, the Company granted to certain employees 140,000 performance-based stock options, or 2022 Performance Awards, primarily related to the achievement of certain regulatory development milestones related to product candidates. Recognition of stock-based compensation expense associated with these performance-based stock options commences when the performance condition is considered probable of achievement, using management’s best estimates, which consider the inherent risk and uncertainty regarding the future outcomes of the milestones.

In the first quarter of 2022, management estimated one of the milestones, for the 2022 Performance Awards, was probable of achievement. The second performance milestone was achieved in November 2024 and 40,000 options were vested. The Company recorded no stock compensation expense in the year ended December 31, 2025, and $0.4 million, and $0.3 million of stock compensation expense for these awards for the years ended December 31, 2024, and 2023, respectively. As of December 31, 2025, 40,000 stock options outstanding were unvested, and 60,000 options had been cancelled related to employee terminations.

In the second quarter of 2023, the Company granted to certain employees 129,550 performance-based RSUs, or 2023 Performance Awards, primarily related to the achievement of certain regulatory development milestones related to product candidates. The Company recorded approximately $0.8 million and $1.0 million of stock compensation related to the achievement of the performance milestones during the year ended December 31, 2025, and 2024, respectively. The Company recorded no stock compensation expense for these awards in the year ended December 31, 2023. As of December 31, 2025, these awards are fully vested.

In the first quarter of 2024, the Company granted to certain employees 35,500 performance-based RSUs, or 2024 Performance Awards, primarily related to the achievement of certain regulatory development milestones related to product candidates. The Company recorded approximately $0.1 million and $0.5 million of stock compensation related to the achievement of the performance milestones during the years ended December 31, 2025, and 2024, respectively. As of December 31, 2025, these awards are fully vested.

In the first quarter of 2024, the Company granted to certain executives 141,725 performance-based RSUs, or 2024 Executive Performance Awards, primarily related to the achievement of revenue targets for Revuforj. The Company recorded approximately $1.5 million of stock compensation related to the achievement of the performance milestones during the year ended December 31, 2025. The Company recorded no stock compensation expense for these awards in the year ended December 31, 2024. The remaining awards will vest upon the first and second year anniversaries of the performance target being achieved.

In the first quarter of 2025, the Company granted to certain executives 252,800 performance-based RSUs , or 2024 Executive Performance Awards, related to the achievement of revenue targets and regulatory development milestones for Revuforj. The Company recorded approximately $0.3 million of stock compensation related to the achievement of the performance milestones during the year ended December 31, 2025. The awards will vest upon compensation committee approval in February 2028. As of December 31, 2025, it is probable that two thirds of these awards will vest and are being expensed as such.

In connection with the termination of eight employees in 2024 and five employees in 2025, the Company entered into severance and consulting agreements. Under these agreements, the Company extended the vesting term for unvested options, which would not have otherwise vested, and extended the exercise period of the vested options post termination of the consulting agreement. For one employee, the Company accelerated the vesting of unvested options that otherwise would have vested in the following twelve month period and extended the exercise period of the vested options post termination of employment. The Company accounted for the change as a modification of an equity award under ASC 718. As a result of the modifications, the Company recognized approximately $1.1 million and $1.2 million of incremental stock compensation expense in the years ended December 31, 2025, and 2024, respectively.

The fair value of each option award is estimated on the date of grant using the Black-Scholes option-pricing model with the weighted-average assumptions noted in the table below. Expected volatility for the Company’s common stock was determined based on an average of the historical volatility of the Company's public stock price. The Company estimated the expected term of its employee stock options using the “simplified” method, whereby, the expected term equals the average of the vesting term and the original contractual term of the option. The

contractual life of the option was used for the estimated life of the non-employee grants. The assumed dividend yield is based upon the Company’s expectation of not paying dividends in the foreseeable future. The risk-free interest rate for periods within the expected life of the option is based upon the U.S. Treasury yield curve in effect at the time of grant. The Company accounts for forfeitures when they occur. The grant date fair values of options issued to employees and non-employees were estimated using the Black-Scholes option-pricing model with the following assumptions:


	Years Ended December 31,
	2025			2024			2023
Expected term (in years)		6.01			6.05			6.03
Volatility rate		68.01	%		71.64	%		75.13	%
Risk-free interest rate		4.08	%		4.15	%		3.65	%
Expected dividend yield		0.00	%		0.00	%		0.00	%

A summary of employee and non-employee option activity under the Company’s equity award plans is presented below (in thousands, except share data):


	Number of Options			Weighted Average Exercise Price		Weighted Average Remaining Contractual Term (in years)		Aggregate Intrinsic Value
Outstanding—January 1, 2025		11,688,079		$	18.63		6.6	$	9,746
Granted		3,976,819		$	13.64
Exercised		(1,135,977	)	$	10.67
Cancelled, forfeited or expired		(1,400,615	)	$	19.62
Outstanding—December 31, 2025		13,128,306		$	17.74		7.0	$	56,881
Exercisable—December 31, 2025		7,525,866					5.6	$	30,174

The weighted-average grant date fair value of options granted during the years ended December 31, 2025, 2024 and 2023, was $8.74, $14.37, and $16.20 per share, respectively. The fair value is being expensed over the vesting period of the options (usually three to four years) on a straight-line basis as the services are being provided.

There were 1,135,977 options exercised for the year ended December 31, 2025, resulting in total proceeds of $12.1 million; 717,413 options exercised for the year ended December 31, 2024, resulting in total proceeds of $8.0 million; and 662,042 options exercised for the year ended December 31, 2023, resulting in total proceeds of $5.1 million. The intrinsic value of options exercised during the years ended December 31, 2025, 2024 and 2023 was $6.8 million, $7.2 million, and $9.5 million, respectively. In accordance with the Company’s policy, the shares were issued from a pool of shares reserved for issuance under the 2015 Plan and 2023 Inducement Plan.

Restricted Stock Units

RSUs awarded to Board of Directors or employees vest on either i) one – year anniversary date of the related grant or ii) 25% on each anniversary for 4 years. The following table summarizes our RSU activity:


	Number of Shares			Weighted Average Grant Date Fair Value
Unvested—December 31, 2024		1,304,087		$	19.46
Granted (1)		2,001,335		$	13.37
Vested		(410,707	)	$	21.31
Cancelled/Forfeited		(277,153	)	$	15.13
Unvested—December 31, 2025		2,617,562		$	16.22

Employee Stock Purchase Plan

In September 2015, the Company’s Board adopted the ESPP, which was subsequently approved by the Company’s stockholders and became effective in 2016. The ESPP authorized the initial issuance of up to a total of 250,000 shares of common stock to the Company’s employees. The number of shares of common stock available under the ESPP will automatically increase on January 1st of each year, continuing until the expiration of the ESPP, in an amount equal to the lesser of (a) 1% of the total number of shares of common stock outstanding on December 31st of the preceding calendar year, or (b) 250,000 shares. On January 1, 2026, the shares of common stock reserved for issuance under the ESPP was increased to 2,252,859. Under the terms of the ESPP, eligible employees can elect to acquire shares of the Company’s common stock through periodic payroll deductions during a series of six-month offering periods. Purchases under the ESPP are affected on the last business day of each offering period at a 15% discount to the lower of closing price on that day or the closing price on the first day of the offering period. The Company issued 164,852 and 64,903 shares during 2025 and 2024, respectively. The ESPP plan will expire in March 2026.

The ESPP is considered a compensatory plan with the related compensation cost expensed over the six-month offering period. For the years ended December 31, 2025, 2024 and 2023 the Company recorded stock-based compensation expense related to the ESPP of $0.8 million, $0.6 million, and $0.3 million respectively.

Employee Benefit Plan

The Company has a Section 401(k) defined contribution savings plan for its employees. The plan covers substantially all employees who meet minimum age and service requirements and allows participants to defer a portion of their annual compensation on a pre- and after-tax basis, subject to legal limitations. Company contributions to the plan may be made at the discretion of the Board. For the years ended December 31, 2025, 2024 and 2023, the Company made $3.2 million, $2.7 million, and $1.3 million contributions to the plan, respectively.

Loss per Share - Computation of Basic and Diluted Earnings (Loss) per Share (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Numerator - basic and diluted:
Net Income (Loss)	$ (285,422)	$ (318,758)	$ (209,360)
Net loss attributable to common stockholders - basic	(285,422)	(318,758)	(209,360)
Net loss attributable to common stockholders - dulited	$ (285,422)	$ (318,758)	$ (209,360)
Denominator - basic and diluted:
Weighted-average common shares outstanding - basic	86,625,610	85,622,065	70,370,519
Weighted-average common shares outstanding - dulited	86,625,610	85,622,065	70,370,519
Shares used in calculating diluted earnings (loss) per share	86,625,610	85,622,065	70,370,519

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

+ Details

- Definition

Amount, after deduction of tax, noncontrolling interests, dividends on preferred stock and participating securities; of income (loss) available to common shareholders.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org/1943274/2147482689/260-10-45-60B

+ Details

- Definition

Amount, after deduction of tax, noncontrolling interests, dividends on preferred stock and participating securities, and addition from assumption of issuance of common shares for dilutive potential common shares; of income (loss) available to common shareholders.

+ References + Details

Stock-Based Compensation - Share Based Compensation Expense Related to Issuance of Stock Option Awards to Employees and Non Employees Related to Employee Stock Purchase Plan (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share based compensation expense, total	$ 47,503	$ 43,026	$ 30,951
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share based compensation expense, total	16,032	19,934	14,147
Selling, general and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share based compensation expense, total	$ 31,471	$ 23,092	$ 16,804

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

Common Stock - Schedule of Common Stock Reserved for Future Issuance (Detail) - shares	Dec. 31, 2025	Apr. 12, 2023
Class Of Stock [Line Items]
Common Stock, Capital Shares Reserved for Future Issuance	30,335,981
Common stock issuable under pre-funded warrants
Class Of Stock [Line Items]
Common Stock, Capital Shares Reserved for Future Issuance	285,714	273,000
Equity plans
Class Of Stock [Line Items]
Common Stock, Capital Shares Reserved for Future Issuance	5,021,284
Employee Stock Option
Class Of Stock [Line Items]
Common Stock, Capital Shares Reserved for Future Issuance	15,745,868
At-the-market program
Class Of Stock [Line Items]
Common Stock, Capital Shares Reserved for Future Issuance	7,280,256
ESPP to purchase common stock
Class Of Stock [Line Items]
Common Stock, Capital Shares Reserved for Future Issuance	2,002,859

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

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+ Details

Stock-Based Compensation - Summary of Restricted Stock Units Activity (Parenthetical) (Details) - Restricted Stock Units (RSUs) [Member] - USD ($) $ / shares in Units, $ in Millions	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Weighted average grant date fair value per share	$ 13.37	$ 18.8
Fair value of restricted stock units vested	$ 8.8	$ 1.8

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

+ Details

Fair Value Measurements - Additional Information (Detail) $ in Thousands	12 Months Ended
	Dec. 31, 2025 USD ($)
Fair Value Disclosures [Abstract]
Realized gains or losses recognized on the sale or maturity of available-for-sale securities	$ 0

Common Stock (Tables)

12 Months Ended

Dec. 31, 2025

Equity [Abstract]

Schedule of Common Stock Reserved for Future Issuance

The Company has reserved for future issuance the following shares of common stock pursuant to the following outstanding securities or equity plans:


	December 31, 2025
Common stock issuable under pre-funded warrants		285,714
At-the-market program		7,280,256
RSUs and Options to purchase common stock		15,745,868
Equity plans		5,021,284
2015 Employee Stock Purchase Plan (the “ESPP”)		2,002,859
Total		30,335,981

Stock-Based Compensation - Additional Information (Detail) - USD ($)

1 Months Ended

3 Months Ended

12 Months Ended

Jan. 01, 2026

Sep. 30, 2015

Mar. 31, 2025

Mar. 31, 2024

Mar. 31, 2023

Dec. 31, 2025

Dec. 31, 2024

Dec. 31, 2023

Dec. 31, 2022

Dec. 31, 2017

Nov. 30, 2024

Feb. 28, 2023

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Shares available for issuance

30,335,981

Share-based compensation, stock options granted

3,976,819

Stock compensation expense

$ 47,503,000

$ 43,026,000

$ 30,951,000

Weighted-average grant date fair value of options granted

$ 8.74

$ 14.37

$ 16.2

Stock options exercised, shares

1,135,977

717,413

662,042

Stock options exercised

$ 12,138,000

$ 8,000,000

$ 5,128,000

Intrinsic value of options exercised

6,800,000

7,200,000

9,500,000

Contributions by the company

3,200,000

2,700,000

1,300,000

2023 Performance Awards

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Stock compensation expense

$ 800,000

1,000,000

2023 Performance Awards | Employees [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Stock option granted to certain employees

129,550

2022 Performance Awards [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Share-based compensation, stock options vested

40,000

Share-based compensation, stock options cancelled

60,000

Stock compensation expense

$ 0

400,000

$ 300,000

Stock option granted to certain employees

140,000

2024 Performance Awards

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Stock compensation expense

$ 100,000

500,000

2024 Performance Awards | Employees [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Stock option granted to certain employees

35,500

2024 Executive Performance Awards [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Stock compensation expense

Stock option granted to certain employees

300,000

1,500,000

2024 Executive Performance Awards [Member] | Employees [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Stock option granted to certain employees

252,800

141,725

Non-vested RSUs

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Vesting period, description

one – year anniversary date of the related grant or ii) 25% on each anniversary for 4 years

Restricted stock units granted

^[1]

2,001,335

Fair value of restricted stock units vested

$ 8,800,000

$ 1,800,000

Restricted stock units vested

410,707

Weighted average grant date fair value per share

$ 13.37

$ 18.8

Maximum [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Vesting period

4 years

Minimum [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Vesting period

3 years

2015 Plan [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Common stock reserved for issuance

1,750,000

Shares available for issuance

4,452,162

Common stock outstanding

4.00%

2015 Plan [Member] | Maximum [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Shares available for issuance

3,496,239

2015 Plan and 2023 Inducement Plan [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Unrecognized compensation expense related to stock option

$ 78,700,000

Weighted average period to recognize compensation expense

2 years 4 months 24 days

Capitalized stock compensation expenset to inventory

$ 460,000,000

$ 53,000,000

2023 Inducement Plan [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Common stock reserved for issuance

1,200,000

1,100,000

1,900,000

Shares available for issuance

569,122

2007 Plan [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Stock compensation expense

$ 1,100,000

$ 1,200,000

ESPP to purchase common stock

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Stock compensation expense

$ 800,000

$ 600,000

$ 300,000

Number of shares issued under plan

164,852

64,903

Expiration of the ESPP

1.00%

expiration of the ESPP shares

250,000

ESPP to purchase common stock | Subsequent Event [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Periodic payroll deductions offering periods

6 months

Offering period discount rate

15.00%

ESPP to purchase common stock | Maximum [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Shares authorized for issuance

250,000

ESPP to purchase common stock | Maximum [Member] | Subsequent Event [Member]

Share-based Compensation Arrangement by Share-based Payment Award [Line Items]

Shares available for issuance

2,252,859

[1]	RSUs granted in 2025 and 2024 had a weighted average grant date fair value of $13.37 and $18.80, respectively. The fair values of RSUs vested in 2025 and 2024 totaled $8.8 million and $1.8 million, respectively.

CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Current assets:
Cash and cash equivalents	$ 134,930	$ 154,083	$ 295,394
Short-term investments	259,140	418,801
Accounts receivable, net	37,996	7,602
Inventory, net	32,754	366
Short-term deposits	19,616	10,029
Other receivables, net	6,404	3,635
Collaboration receivable, net	23,745	0
Prepaid expenses and other current assets	13,496	8,541
Total current assets	528,081	603,057
Long-Term Investments	0	119,520
Property and equipment, net	181	0
Right-of-use asset	1,342	2,022
Restricted cash	102	217
Total assets	529,706	724,816
Current liabilities:
Accounts payable	16,580	11,626
Collaboration payable, net	0	19,231
Accrued expenses and other current liabilities	103,064	60,096
Current portion of royalty interest financing	0	12,116
Current portion of right-of-use liability	470	471
Current Portion Of Capital Lease	2	9
Total current liabilities	120,116	103,549
Long-term liabilities:
Royalty interest financing, less current portion	343,909	331,565
Right-of-use liability, less current portion	1,051	1,578
Total long-term liabilities	344,960	333,143
Total liabilities	465,076	436,692
Commitments and contingencies (Note 18)
Stockholders' equity:
Preferred stock, $0.001 par value, 10,000,000 shares authorized; 0 shares outstanding at December 31, 2025 and December 31, 2024	0	0
Common stock, $0.0001 par value, 200,000,000 shares authorized at December 31, 2025 and December 31, 2024, respectively; 87,405,979 and 85,694,443 shares outstanding at December 31, 2025 and December 31, 2024, respectively	9	9
Additional paid-in capital	1,570,749	1,509,110
Accumulated other comprehensive income	452	163
Accumulated deficit	(1,506,580)	(1,221,158)
Total stockholders' equity	64,630	288,124	$ 554,196
Total liabilities and stockholders' equity	$ 529,706	$ 724,816

Commitments and Contingencies

12 Months Ended

Dec. 31, 2025

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies

18. Commitments and Contingencies

License Agreements

In April 2013, the Company entered into Eddingpharm License Agreement and a Series B-1 purchase agreement with Eddingpharm. Under the terms of the Eddingpharm License Agreement, Eddingpharm, in exchange for rights to develop and commercialize entinostat in China and certain other Asian countries, purchased $5.0 million of Series B-1 and agreed to make certain contingent milestone and royalty payments based on revenue targets. In certain cases, the Company is required to assist Eddingpharm, and Eddingpharm is required to reimburse the Company for any out-of-pocket expenses incurred in providing this assistance, including reimbursement for person-hours above a certain cap.

The Company is obligated to pay royalties pursuant to the Vitae License Agreement, as a percentage of net product sales for direct licensed products, such as Revuforj. The obligation to pay royalties expires, on a country-by-country basis and licensed product-by-licensed product basis until the later of expiration of the last valid claim of a patent right, the expiration of the applicable regulatory exclusivity for such licensed product in such county, or 10 years from the first commercial sale of a licensed product in each country. These fees were recorded as cost of product sales.

From time to time, the Company may be subject to various claims and proceedings in the ordinary course of business. If the potential loss from any claim, asserted or unasserted, or proceeding is considered probable and the amount is reasonably estimable, the Company will accrue a liability for the estimated loss. There were no contingent liabilities recorded as of December 31, 2025, or 2024.

Insider Trading Arrangements	3 Months Ended
Insider Trading Arrangements	Dec. 31, 2025
Trading Arrangements, by Individual
Rule 10b5-1 Arrangement Adopted	false
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
Non-Rule 10b5-1 Arrangement Terminated	false

Income Taxes - Components of Deferred Tax (Detail) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Deferred tax assets (liabilities):
Net operating loss carryforwards	$ 135,517	$ 43,362
Research and development credits	13,519	16,074
Orphan drug credits	26,991	0
Capitalized start-up and other costs	80,089	84,870
Capitalized research and development costs	59,475	97,780
Equity based compensation	15,348	13,687
Accruals	5,021	2,829
Disallowed interest	2,489	0
Other temporary differences	1,257	36
Deferred tax assets before valuation allowance	339,706	258,638
Valuation allowances	(339,706)	(258,638)
Net deferred tax assets	$ 0	$ 0

Inventory

12 Months Ended

Dec. 31, 2025

Inventory Disclosure [Abstract]

Inventory

9. Inventory, net

Inventory consisted of the following (in thousands):


	December 31,
	2025		2024
Raw materials	$	29,027	$	—
Work-in-process		2,112		330
Finished goods		1,615		36
Total Inventory	$	32,754	$	366

Inventories are stated at the lower of cost or net realizable value, as determined on a first-in, first-out basis.

Prior to the FDA's approval of Revuforj in November 2024, all costs for the manufacturing of product to support clinical development and commercial launch, including pre-launch inventory, were expensed as research and development costs. The pre-launch inventory will continue to be used in commercial production until it is depleted.

We have recorded a reserve of $0.2 million for inventory expected to expire in the first quarter of 2026. This reserve is reflected as a reduction of the carrying value of inventory.

Accrued Expenses and Other Current Liabilities (Tables)

12 Months Ended

Dec. 31, 2025

Payables and Accruals [Abstract]

Schedule of Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consisted of the following (in thousands):


	December 31,
	2025		2024
Product revenue allowances	$	9,810	$	849
Accrued clinical study and trial costs		18,977		23,869
Accrued selling, general, and administrative costs		6,316		4,258
Accrued compensation and related costs		24,352		14,477
Accrued professional fees		-		385
Accrued milestone costs		10,000		10,600
Accrued royalty payable		7,372		307
Accrued interest - debt		25,516		4,930
Other		721		421
Total accrued expense and other current liabilities	$	103,064	$	60,096

Significant Agreements - Additional Information (Detail) - USD ($) $ in Thousands	1 Months Ended				3 Months Ended						12 Months Ended
	Oct. 31, 2017	Jul. 31, 2016	Dec. 31, 2007	Mar. 31, 2007	Dec. 31, 2025	Mar. 31, 2025	Sep. 30, 2024	Jun. 30, 2022	Dec. 31, 2017	Sep. 30, 2016	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2017
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Research and development expense											$ 258,784	$ 241,647	$ 163,032
Accrued expenses					$ 103,064						103,064	60,096
Allergan License Agreement [Member] \| Vitae Pharmaceuticals Inc [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront milestone payable									$ 5,000
Potential milestone payments to be made	$ 99,000
Aggregate potential milestone payable	$ 70,000
License expiration year	10 years
Research and development expense														$ 5,000
Development and regulaotry milestones expenses					38,000						38,000
Milestone expenses paid					12,000						12,000	$ 18,000
UCB License Agreement [Member] \| UCB Biopharma [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront milestone payable										$ 5,000
Potential milestone payments to be made		$ 119,500
Aggregate potential milestone payable		$ 250,000
License expiration year		10 years
Research and development expense						$ 10,000	$ 15,000				41,000
Milestone payment payable					10,000			$ 5,800
Milestone expenses paid					$ 150,000						$ 150,000
License Agreement [Member] \| Bayer Pharma AG [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Research and development expense			$ 2,000
Up-front license fee paid				$ 2,000
License Agreement [Member] \| Bayer Pharma AG [Member] \| Maximum [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Aggregate payment obligation				$ 150,000

Loss per Share (Tables)

12 Months Ended

Dec. 31, 2025

Earnings Per Share [Abstract]

Computation of Basic and Diluted Earnings (Loss) per Share

Basic and diluted loss per share are calculated as follows (in 000s except share data):


	Years Ended December 31,
	2025			2024			2023
Numerator - basic and diluted:
Net loss - basic and diluted	$	(285,422	)	$	(318,758	)	$	(209,360	)
Net loss attributable to common stockholders - basic and diluted	$	(285,422	)	$	(318,758	)	$	(209,360	)
Denominator - basic and diluted:
Weighted-average common shares outstanding - basic and diluted		86,625,610			85,622,065			70,370,519

Potential Dilutive Securities Excluded from Computation of Diluted Net Loss per Common Share


	December 31,
	2025		2024		2023
Options to purchase common		13,128		11,688		10,685
Non-vested RSUs		2,618		1,304		309
ESPP to purchase common stock		127		70		35

Summary of Significant Accounting Policies

12 Months Ended

Dec. 31, 2025

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

3. Summary of Significant Accounting Policies

Estimates

The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of costs and expenses during the reporting period. The Company bases estimates and assumptions on historical experience when available and on various factors that it believes to be reasonable under the circumstances. The Company evaluates its estimates and assumptions on an ongoing basis. The Company’s actual results may differ from these estimates under different assumptions or conditions.

Estimates and assumptions about future events and their effects cannot be determined with certainty and therefore require the exercise of judgment. As of the date of issuance of these financial statements, the Company is not aware of any specific event or circumstance that would require the Company to update its estimates, assumptions and judgments or revise the carrying value of its assets or liabilities. These estimates may change as new events occur and additional information is obtained and are recognized in the consolidated financial statements as soon as they become known. Actual results could differ from those estimates and any such differences may be material to the Company’s consolidated financial statements.

Cash Equivalents

Cash equivalents include all highly liquid investments maturing within 90 days or less from the date of purchase. Cash equivalents include money market funds, corporate debt securities, U.S. government agency notes, and overnight deposits.

Restricted Cash

The Company classifies as restricted cash all cash pledged as collateral to secure long-term obligations and all cash whose use is otherwise limited by contractual provisions. Amounts are reported as non-current unless restrictions are expected to be released in the next 12 months.

Marketable Securities

All investments in marketable securities are classified as available-for-sale and are reported at fair value with unrealized gains and losses excluded from earnings and reported net of tax in accumulated other comprehensive income, which is a component of stockholders’ equity. Unrealized losses that are determined to be other-than-temporary, based on current and expected market conditions, are recognized in earnings. Declines in fair value determined to be credit related are charged to earnings. The cost of marketable securities sold is determined by the specific identification method.

Segment Reporting

Operating segments are identified as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision maker, or CODM, or decision-making group, in making decisions regarding resource allocation and assessing performance. The CODM is the Company's Chief Executive Officer. The Company has one operating and reportable segment.

Concentrations of Credit Risk

Cash and cash equivalents, restricted cash, and short- and long-term investments are financial instruments that potentially subject the Company to concentrations of credit risk. Substantially all of the Company’s cash, cash equivalents, and short- and long-term investments were deposited in accounts at two financial institutions, and at times, such deposits may exceed federally insured limits. The Company has not experienced any losses in such accounts, and management believes that the Company is not exposed to significant credit risk due to the financial position of the depository institutions in which those deposits are held. The Company’s available-for-sale investments primarily consist of government money market funds, corporate debt securities, commercial paper, credit card asset-backed securities and overnight deposits and potentially subject the Company to concentrations of credit risk.

Customer and Supplier Concentration

The Company has exposure to credit risk in accounts receivable from sales of Revuforj. Revuforj is sold to Specialty Distributors and Specialty Pharmacies, who subsequently sell Revuforj to pharmacies, hospitals and other customers. Four customers represented 92% of the Company's accounts receivable and net product sales as of and for the year ended December 31, 2025.

Five customers represented 100% of the Company's accounts receivable and net product sales as of and for the year ended December 31, 2024.

The Company outsources the manufacturing of its products to contract manufacturers. In addition, the Company currently relies on a limited number of suppliers for the active pharmaceutical ingredients in its products. Accordingly, the Company has concentration risk associated with its commercial manufacturing.

Accounts Receivable

Accounts receivable primarily relates to amounts due from customers, which are typically due within 45 to 65 days. The Company analyzes accounts that are past due for collectability. To date, the Company has not experienced any credit losses with respect to the collection of its accounts receivable and has not recorded an allowance for credit losses as of December 31, 2025 and 2024. The Company has no financial instruments with off balance sheet risk of loss.

Inventory

Inventories are stated at the lower of cost or net realizable value. Costs of inventories, which include amounts related to materials and manufacturing overhead, are determined on a first-in, first-out basis. An assessment of the

recoverability of capitalized inventory is performed during each reporting period and any excess and obsolete inventories are reserved for or written down to their estimated net realizable value in the period in which the impairment is first identified. The Company has recognized prepaid inventory within prepaid expenses and other current assets for the year ended December 31, 2025, representing the cost of goods purchased in advance from vendors, which will be recognized as inventory upon delivery and acceptance to the Company's designated location.

Property and Equipment

Property and equipment are recorded at cost. Depreciation is recorded using the straight-line method over the estimated useful lives of the assets (three to five years). Assets under capital leases are amortized over the shorter of their useful lives or lease term using the straight-line method. Major replacements and improvements are capitalized, while general repairs and maintenance are expensed as incurred.

Impairment of Long-Lived Assets

Long-lived assets are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of the asset may not be recoverable. When such events occur, the Company compares the carrying amounts of the assets to their undiscounted expected future cash flows. If this comparison indicates that there is impairment, the amount of impairment is calculated as the difference between the carrying value and fair value. To date, no such impairments have been recognized.

Revenue Recognition

The Company recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration which we expect to receive in exchange for those goods or services. The Company recognize revenue following the five – step model prescribed under FASB Accounting Standards Codification (ASC 606), Revenue from Contracts with Customers: (i) identify contract(s) with customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) we satisfy the performance obligations. The Company only recognizes revenue when it is probable that it will collect the consideration to which it is entitled in exchange for the goods or services that will be transferred to the customer.

Product Revenue:

The Company sells Revuforj to specialty distributors and specialty pharmacies, or collectively, Customers. These Customers subsequently resell Revuforj to healthcare providers, patients and other pharmacies. In addition to agreements with Customers, the Company enters into arrangements with healthcare providers and payors that provide for government-mandated and/or privately-negotiated rebates, chargebacks and discounts for the purchase of Revuforj.

The Company recognizes revenue from product sales at the point Customers obtain control of the product, which generally occurs upon delivery. The transaction price that is recognized as product revenue includes an estimate of variable consideration which is described below. Payment terms with Customers do not exceed one year and, therefore, the Company does not account for a financing component in its arrangements. The Company expenses incremental costs of obtaining a contract with a Customer (for example, sales commissions) when incurred as the period of benefit is less than one year. Shipping and handling costs for product shipments to Customers are recorded as selling, general and administrative expenses.

Revenue from products is recognized at the estimated net sales price (transaction price), which includes estimates of variable consideration. The Company includes estimated amounts in the transaction price to the extent it is determined probable that a significant reversal of cumulative revenue recognized will not occur when the uncertainty associated with the variable consideration is resolved. The Company’s estimates of variable consideration and determination of whether to include estimated amounts in the transaction price are based largely on an assessment of its anticipated performance and all information (historical, current and forecasted) that is reasonably available. The components of the Company's variable consideration include the following:

Provider Chargebacks and Discounts

Chargebacks for fees and discounts to providers represent the estimated obligations resulting from contractual commitments to sell products to qualified healthcare providers at prices lower than the list prices charged to

Customers who directly purchase the product from the Company. Customers charge the Company for the difference between what they pay for the product and the ultimate selling price to the qualified healthcare providers. These components of variable consideration are established in the same period that the related revenue is recognized, resulting in a reduction of product revenue and accounts receivable. These reserves are recorded as a reduction of revenue and accounts receivable in the period in which the related product revenue is recognized.

Trade Discounts and Allowances

The Company generally provides Customers with discounts that include incentive fees which are explicitly stated in the Company’s contracts. These discounts are recorded as a reduction of revenue and accounts receivable in the period in which the related product revenue is recognized. These reserves are recorded as a reduction of revenue and accounts receivable in the period in which the related product revenue is recognized.

Product Returns

Consistent with industry practice, the Company has a product returns policy that provides Customers a right of return for product purchased within a specified period prior to and subsequent to the product’s expiration date. The Company estimates the amount of its products that may be returned and presents this amount as a reduction of revenue in the period the related product revenue is recognized, in addition to establishing a current liability. The Company considers several factors in the estimation process, including expiration dates of product shipped to Customers, inventory levels within the distribution channel, product shelf life, prescription trends and other relevant factors. These reserves are recorded as a reduction of revenue in the period in which the related product revenue is recognized.

Government Rebates

The Company is subject to discount obligations under state Medicaid programs and Medicare. Reserves related to these discount obligations are recorded in the same period the related revenue is recognized, resulting in a reduction of product revenue and the establishment of a current liability. The Company’s liability for these rebates consists of estimates of claims for the current reporting period and estimated future claims that will be made for product that has been recognized as revenue but remains in the distribution channel inventories at the end of the reporting period. These reserves are recorded as a reduction of revenue in the period in which the related product revenue is recognized.

Patient Assistance

Other programs that the Company offers include voluntary co-pay patient assistance programs intended to provide financial assistance to eligible patients with prescription drug co-payments required by payors and coupon programs for cash payors. The calculation of the current liability for this assistance is based on an estimate of claims and the cost per claim that the Company expects to receive associated with product that has been recognized as revenue but remain as in the distribution channel inventories at the end of each reporting period. These reserves are recorded as a reduction of revenue in the period in which the related product revenue is recognized.

Distribution and Other Fees

We pay distribution and other fees to certain customers in connection with the sales of our products. We record distribution and other fees paid to our customers as a reduction of revenue, unless the payment is for a distinct good or service from the customer and we can reasonably estimate the fair value of the goods or services received. If both conditions are met, we record the consideration paid to the customer as an operating expense. These costs are typically known at the time of sale, resulting in minimal adjustments subsequent to the period of sale. These reserves are recorded as a reduction of revenue in the period in which the related product revenue is recognized.

Development Milestone Payments: The Company evaluates whether milestones are considered probable of being reached and estimates the amount to be included in the transaction price using the most likely amount method. If it is probable that a significant revenue reversal would not occur, the associated milestone value is included in the transaction price. Milestone payments that are not within the control of the Company or the licensee, such as regulatory approvals, are generally not considered probable of being achieved until those approvals are received. The transaction price is then allocated to each performance obligation on a relative stand-alone selling price basis, for which the Company recognizes revenue as or when the performance obligations under the contract are satisfied. At the end of each subsequent reporting period, the Company re-evaluates the probability of achievement of such development milestones and any related constraint, and if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect license fees and earnings in the period of adjustment.

Commercial Milestone Payments and Royalties: For arrangements that include sales-based royalties, including milestone payments based on the level of commercial sales, and the license is deemed to be the predominant item to which the royalties or commercial milestones relate, the Company will recognize revenue at the later of when the related sales occur or when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied). A $10.0 million commercial milestone expense was recognized as part of selling, general and administrative expenses in the fourth quarter of 2025 upon the achievement of $150.0 million of net sales of Niktimvo.

When no performance obligations are required of the Company, or following the completion of the performance obligation period, such amounts are recognized as revenue upon transfer of control of the goods or services to the customer. Generally, all amounts received or due other than sales-based milestones and royalties are classified as license fees.

Deferred revenue arises from amounts received in advance of the culmination of the earnings process and is recognized as revenue in future periods as performance obligations are satisfied. Deferred revenue expected to be recognized within the next twelve months is classified as a current liability. Upfront payment contract liabilities resulting from the Company’s license agreements do not represent a financing component as the payment is not financing the transfer of goods or services, and the technology underlying the licenses granted reflects research and development expenses already incurred by the Company.

For additional information on our collaboration and license arrangements, please read Note 4, Collaborative Research and License Agreements, to these consolidated financial statements.

Advertising expenses

The Company expenses the costs of advertising, including promotional expenses, as incurred. Advertising expenses were $14.4 million, $7.3 million, and $6.1 million for the years ended December 31, 2025, 2024, and 2023, respectively.

Research and Development

Research and development costs are expensed as incurred. Research and development expenses include payroll and personnel expenses, consulting costs, external contract research and development expenses, and allocated overhead, including rent, equipment depreciation, and utilities. Research and development costs that are paid in advance of performance are capitalized as a prepaid expense and amortized over the service period as the services are provided. The Company expenses upfront license payments related to acquired technologies that have not yet reached technological feasibility and have no alternative future use.

In instances where the Company enters into cost-sharing arrangements, all research and development costs reimbursed by the collaborators are accounted for as reductions to research and development expense. During the years ended December 31, 2025, 2024 and 2023 the Company has incurred external costs related to the Incyte cost-sharing collaboration.

Clinical Costs

Clinical study and trial costs are a component of research and development expenses. The Company expenses clinical trial activities performed by third parties based on an evaluation of the progress to completion of specific contract tasks using data such as patient enrollment, clinical site activations, or other information provided to us by our vendors. Depending on the progression of the contract and timing of invoicing and payment the research and development expense can be an accrued expense or a prepaid expense. Prepaid clinical study and trial costs are included in short-term deposits on the accompanying consolidated balance sheet.

Income Taxes

The Company records deferred tax assets and liabilities for the expected future tax consequences of temporary differences between the Company’s financial statement carrying amounts and the tax bases of assets and liabilities and for loss and credit carryforwards using enacted tax rates expected to be in effect in the years in which the differences reverse. A valuation allowance is provided to reduce the net deferred tax assets to the amount that will more likely than not be realized. The Company determines whether it is more likely than not that a tax position will be sustained upon examination. If it is not more likely than not that a position will be sustained, none of the benefit attributable to the position is recognized. The tax benefit to be recognized for any tax position that meets the more-likely-than-not recognition threshold is calculated as the largest amount that is more than 50% likely of being realized upon resolution of the contingency. The Company accounts for interest and penalties related to uncertain tax positions as part of its provision for income taxes.

Guarantees and Indemnifications

As permitted under Delaware law, the Company indemnifies its officers, directors, and employees for certain events or occurrences that happen by reason of the relationship with, or position held at, the Company. The Company has standard indemnification arrangements under office leases (as described in Note 5, Leases to these consolidated financial statements) that require it to indemnify the landlord against all costs, expenses, fines, suits, claims, demands, liabilities, and actions directly resulting from any breach, violation, or nonperformance of any covenant or condition of the Company’s lease. Through December 31, 2025, the Company had not experienced any losses related to these indemnification obligations and no claims were outstanding. The Company does not expect significant claims related to these indemnification obligations, and consequently, concluded that the fair value of these obligations is negligible, and no related reserves were established.

Stock-Based Compensation

The Company accounts for all stock option awards granted to employees and non-employees using a fair value method. Stock-based compensation is measured at the grant date fair value of the stock option grants and is recognized over the requisite service period of the awards (usually the vesting period) on a straight-line basis. For equity awards that have a performance condition, the Company recognizes compensation expense based on its assessment of the probability that the performance condition will be achieved. The Company accounts for forfeitures as they occur.

(Loss) Earnings Per Share

Basic earnings per share is computed by dividing undistributed net income attributable to the Company by the weighted-average number of common shares outstanding during the period. Diluted earnings per share is computed based on the treasury method by dividing net income by the weighted-average number of common shares outstanding during the period plus potentially dilutive common equivalent shares outstanding.

Recently Issued and Adopted Accounting Pronouncements

From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board FASB or other accounting standard setting bodies that we adopt as of the specified effective date. Unless otherwise discussed below, we do not believe that the adoption of recently issued standards have or may have a material impact on our consolidated financial statements or disclosures.

In December 2023, the FASB issued Accounting Standards Update (“ASU”) 2023-09, Improvements to Income Tax Disclosures (“ASU 2023-09”), which intends to enhance the transparency, as well as the usefulness, of

income tax disclosures, primarily related to the rate reconciliation and income taxes paid. The Company has adopted the guidance relevant to ASU 2023-09 prospectively, expanding its applicable income tax disclosures.

In November 2024, the FASB issued ASU 2024-03, Income Statement—Reporting Comprehensive Income—Expense Disaggregation Disclosures (Subtopic 220-40): Disaggregation of Income Statement Expenses (ASU “2024-03”). Among other items, the requirements include expanded disclosures around employee compensation and selling expenses. ASU 2024-03 will be effective for the Company for the year ending December 31, 2027. The Company is still evaluating the impact of this new guidance on its unaudited consolidated financial statements but expects the adoption to result in disclosure changes only.

Fair Value Measurements - Summary of Available-for-Sale Securities (Detail) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	$ 258,688	$ 538,158
Unrealized Gains	452	219
Unrealized Losses	0	(56)
Fair Value	259,140	538,321
Commercial Paper
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	86,066	263,952
Unrealized Gains	15
Unrealized Losses		(56)
Fair Value	86,081	263,896
Corporate Bonds
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	28,227	40,261
Unrealized Gains	30	0
Fair Value	28,257	40,261
US Treasury
Schedule Of Available For Sale Securities [Line Items]
Amortized Cost	144,395	233,945
Unrealized Gains	407	219
Fair Value	$ 144,802	$ 234,164

- Definition

Amount of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

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+ Details

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (b)
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-URI https://asc.fasb.org/1943274/2147481800/320-10-50-2

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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-SubTopic 10
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-Section 50
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-URI https://asc.fasb.org/1943274/2147481800/320-10-50-3

+ Details

Basis of Presentation (Additional Information) (Details) $ in Millions	Dec. 31, 2024 USD ($)
Accounting Policies [Abstract]
Royalty payable	$ 0.3

Purchase and Sale Agreement (Additional Information) (Details) - Purchase and Sale Agreement [Member] - USD ($) $ in Millions		12 Months Ended
	Nov. 04, 2024	Dec. 31, 2025	Dec. 31, 2024
Purchase and Sale Agreement [Line Items]
Bank and legal fees	$ 6.3
Company effective annual interest rate		13.02%
Interest expense		$ 33.8	$ 5.0
Payments on Purchase and Sale agreement		$ 13.2
United States [Member]
Purchase and Sale Agreement [Line Items]
Percentage of net sales to royalty rate	13.80%
Revenue participation right	$ 822.5

- Definition

Amount of interest expense classified as operating and nonoperating. Includes, but is not limited to, cost of borrowing accounted for as interest expense.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 22
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-22

Reference 2: http://www.xbrl.org/2003/role/exampleRef
-Topic 280
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Reference 3: http://www.xbrl.org/2003/role/exampleRef
-Topic 280
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-Section 55
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482785/280-10-55-49

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 270
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-Paragraph 1
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-URI https://asc.fasb.org/1943274/2147482964/270-10-50-1

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
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-Paragraph 32
-Subparagraph (ee)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-32

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
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-Name Accounting Standards Codification
-Section 50
-Paragraph 24
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-URI https://asc.fasb.org/1943274/2147482810/280-10-50-24

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 280
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 22
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482810/280-10-50-22

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 835
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147483013/835-20-50-1

Reference 9: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 946
-SubTopic 220
-Name Accounting Standards Codification
-Section 45
-Paragraph 3
-Subparagraph (i)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479105/946-220-45-3

+ Details

Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Revenue:
Total Revenue	$ 172,352	$ 23,680	$ 0
Type of revenue [extensible list]	us-gaap:LicenseMember	us-gaap:LicenseMember	us-gaap:LicenseMember
Operating expenses:
Cost of product sales	$ 6,970	$ 826	$ 0
Research and development expenses	258,784	241,647	163,032
Selling, general and administrative	179,682	120,879	66,922
Total operating expenses	445,436	363,352	229,954
Loss from operations	(273,084)	(339,672)	(229,954)
Other income (expense):
Royalty interest expense	(33,779)	(4,930)	0
Other interest (expense) income	(6)	1	(208)
Interest income	22,730	26,090	21,163
Other expense, net	(1,283)	(247)	(361)
Total other income	(12,338)	20,914	20,594
Net income	(285,422)	(318,758)	(209,360)
Net loss attributable to common stockholders	$ (285,422)	$ (318,758)	$ (209,360)
Net loss Per Share:
Basic loss per share attributable to common stockholders	$ (3.29)	$ (3.72)	$ (2.98)
Diluted loss per share attributable to common stockholders	$ (3.29)	$ (3.72)	$ (2.98)
Weighted-average common shares used in calculating:
Basic loss per share attributable to common stockholders	86,625,610	85,622,065	70,370,519
Diluted loss per share attributable to common stockholders	86,625,610	85,622,065	70,370,519
Net product revenue
Revenue:
Total Revenue	$ 124,844	$ 7,680	$ 0
Collaboration revenue [Member]
Revenue:
Total Revenue	42,367	0	0
Milestone revenue
Revenue:
Total Revenue	$ 5,141	$ 16,000	$ 0

Segment Reporting (Additional Information) (Details)	12 Months Ended
Segment Reporting (Additional Information) (Details)	Dec. 31, 2025 Segment
Segment Reporting [Abstract]
Number of Reportable Segments	1
Number of Operating Segments	1

Prepaid Expenses and Other Current Assets - Schedule of Prepaid Expenses and Other Current Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Prepaid insurance	$ 1,590	$ 1,276
Interest receivable on investments	2,146	2,634
Prepaid subscriptions	2,221	1,605
Prepaid state and local taxes	13	298
Prepaid rent	55	107
Prepaid inventory	6,252	2,009
Other	1,219	612
Total prepaid expenses and other current assets	$ 13,496	$ 8,541

Income Taxes - Summary of Reconciliation of Company's Unrecognized Tax Benefits (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Unrecognized Tax Benefits [Roll Forward]
Unrecognized tax benefit--beginning of year	$ 143	$ 143	$ 143
Decreases related to prior period positions	0	0	0
Unrecognized tax benefit--end of year	$ 143	$ 143	$ 143

Supplemental Cash Flow Information (Tables)

12 Months Ended

Dec. 31, 2025

Supplemental Cash Flow Elements [Abstract]

Supplemental Disclosures of Cash Flow Information

Supplemental disclosure of cash paid during the period for income taxes (net of refunds received):


	Year Ended December 31,
	2025
Tennessee	$	0.07
New York		0.06
Massachusetts		0.01
Other		0.01
Total cash taxes paid, net of refunds received	$	0.15

Purchase and Sale Agreement (Tables)

12 Months Ended

Dec. 31, 2025

Purchase and Sale Agreement [Abstract]

Schedule of Term Loan Payables


	December 31,
	2025			2024
Current portion of royalty interest financing	$	-		$	12,116
Royalty interest financing, less current portion		350,000			337,884
Debt issuance costs		(6,091	)		(6,319	)
Royalty interest financing, net	$	343,909		$	343,681

Loss per Share - Potential Dilutive Securities Excluded from Computation of Diluted Net Loss per Common Share (Detail) - shares	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Options to purchase common
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Anti-dilutive securities excluded from computation of diluted net loss per common share	13,128	11,688	10,685
Non-vested RSUs
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Anti-dilutive securities excluded from computation of diluted net loss per common share	2,618	1,304	309
ESPP to purchase common stock
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Anti-dilutive securities excluded from computation of diluted net loss per common share	127	70	35

Prepaid Expenses and Other Current Assets (Tables)

12 Months Ended

Dec. 31, 2025

Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]

Schedule of Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consisted of the following (in thousands):


	December 31,
	2025		2024
Prepaid insurance	$	1,590	$	1,276
Interest receivable on investments		2,146		2,634
Prepaid subscriptions		2,221		1,605
Prepaid state and local taxes		13		298
Prepaid rent		55		107
Prepaid inventory		6,252		2,009
Other		1,219		612
Total prepaid expenses and other current assets	$	13,496	$	8,541

Income Taxes

12 Months Ended

Dec. 31, 2025

Income Tax Disclosure [Abstract]

Income Taxes

17. Income Taxes

For the years ending December 31, 2025, and December 31, 2024, the Company recognized current state income tax expense of $0.4 million and $0.3 million, respectively, recorded under selling, general and administrative expense. The Company’s current year profit and historical losses before income tax for the periods presented was generated entirely in the United States.

Reconciliation of the differences between the effective income tax rate and federal statutory rate for the year ended December 31, 2025 (in thousands):


	Amount			Percent
Income tax computed at federal statutory rate	$	(59,830	)		21.0		%
State taxes, net of federal benefit		342			(0.1	)
Tax Credits
Research and development		2,529			(0.9	)
Orphan drug		(26,991	)		9.5
Nontaxable or Nondeductible items
Stock option deduction		3,060			(1.1	)
Non-deductible officer compensation		3,234			(1.1	)
Other		202			(0.1	)
Other Adjustments
Other		363			(0.1	)
Change in valuation allowance		77,524			(27.3	)
Effective tax rate	$	433			(0.2	)	%

As previously disclosed for the years ended December 31, 2024, and 2023, prior to the adoption of ASU 2023-09, the following is a reconciliation of the difference between the effective income tax rate and the federal statutory rate:


	Years Ended December 31,
	2024			2023
Income tax computed at federal statutory rate		21.0	%		21.0	%
State taxes, net of federal benefit		-0.1	%		13.2	%
General business credit carryovers		1.1	%		1.5	%
Non-deductible expenses		-1.0	%		-1.0	%
Change in valuation allowance		-17.3	%		-34.9	%
Return to provision true up		-3.8	%		0.0	%
Other		0.0	%		0.0	%
		-0.1	%		-0.2	%

The significant components of the Company’s deferred tax are as follows (in thousands):


	Years Ended December 31,
	2025			2024
Deferred tax assets (liabilities):
Net operating loss carryforwards	$	135,517		$	43,362
Research and development credits		13,519			16,074
Orphan drug credits		26,991			—
Capitalized start-up and other costs		80,089			84,870
Capitalized research and development costs		59,475			97,780
Equity based compensation		15,348			13,687
Accruals		5,021			2,829
Disallowed interest		2,489			—
Other temporary differences		1,257			36
Deferred tax assets before valuation allowance		339,706			258,638
Valuation allowances		(339,706	)		(258,638	)
Net deferred tax assets	$	—		$	—

Supplemental disclosure of cash paid during the period for income taxes (net of refunds received):


	Year Ended December 31,
	2025
Tennessee	$	0.07
New York		0.06
Massachusetts		0.01
Other		0.01
Total cash taxes paid, net of refunds received	$	0.15

The One Big Beautiful Bill Act, or OBBBA, was signed into law on July 4, 2025. The OBBBA includes significant changes affecting business taxpayers, with various effective dates. Among the provisions impacting the Company is Section 174A, which permits current expensing of domestic research and experimental, or R&E, expenditures. The Company elected to currently deduct domestic R&E costs incurred during the year and did not elect to accelerate deductions for domestic R&E costs capitalized in prior years. Foreign R&E expenditures continue to be amortized over 15 years under Section 174.

For the fiscal year ended December 31, 2025, the Company was subject to the Section 163(j) business interest expense limitation based on its average annual gross receipts (as determined under Section 448(c)). For tax

years beginning after December 31, 2024, the OBBBA modifies the Section 163(j) Adjusted Taxable Income (“ATI”) calculation to allow an add-back for depreciation and amortization.

The Company has provided a valuation allowance for the full amount of the net deferred tax assets as the realization of the deferred tax assets is not determined to be more likely than not. The valuation allowance increased by $81.1 million in 2025 due to the increase in deferred tax assets, primarily driven by the generation of net operating losses, and capitalized research expenses. The valuation allowance increased by $52.7 million in 2024 due to the increase in deferred tax assets, primarily driven by the generation of net operating losses and capitalized research expenses, and capitalized start-up costs.

As of December 31, 2025, the Company had approximately $585.3 million and $227.7 million in federal and state net operating losses, or NOLs, respectively, which may be available to offset future taxable income. The Company has generated federal NOLs of $563.2 million and state NOLs of $8.7 million which have indefinite carryforward period. The remaining $22.1 million of federal NOLs and $219.0 million the Company’s state NOLs will begin to expire at various dates starting in 2026. Effective January 1, 2024, the Company has been reclassified as an active trade or business for tax purposes. This resulted in a reclassification of capitalized start-up and other costs to net operating losses and valuation allowance in the 2025 tax statements.

As of December 31, 2025, the Company had available research and development and orphan drug tax credits of approximately $9.8 million and $27.0 million, respectively. Income tax credits began to expire in 2024.

Realization of future tax benefits is dependent on many factors, including the Company’s ability to generate taxable income within the net operating loss carryforward period. Under the Internal Revenue Code provisions, certain substantial changes in the Company’s ownership, including the sale of the Company or significant changes in ownership due to sales of equity, may have limited, or may limit in the future, the amount of net operating loss carryforwards which could be used annually to offset future taxable income. The Company last completed an analysis from January 1, 2023 through December 31, 2023 and determined that no ownership changes had occurred in that period. Prior analyses determined that on March 30, 2007, August 21, 2015 and May 4, 2020, ownership changes had occurred. The Company may also experience ownership changes in the future as a result of subsequent shifts in our stock ownership, some of which may be outside of our control. As a result, its ability to use its pre- change NOLs to offset U.S. federal taxable income may be subject to limitations, which could potentially result in increased future tax liability. In addition, at the state level, there may be periods during which the use of NOLs is suspended or otherwise limited, which could accelerate or permanently increase state taxes owed.

As of December 31, 2025, and 2024, the Company had uncertain tax positions of $0.1 million related to research and development credits, which reduce the deferred tax assets with a corresponding decrease to the valuation allowance. The Company has elected to recognize interest and penalties related to income tax matters as a component of income tax expense, of which no interest or penalties were recorded for the years ended December 31, 2025 and 2024. The Company expects none of the unrecognized tax benefits to decrease within the next 12 months related to expired statutes or settlement with the taxing authorities. Due to the Company’s valuation allowance as of December 31, 2025, none of the Company’s unrecognized tax benefits, if recognized, would affect the effective tax rate.

A reconciliation of the Company’s unrecognized tax benefits is as follows (in thousands):


	Years Ended December 31,
	2025		2024		2023
Unrecognized tax benefit--beginning of year	$	143	$	143	$	143
Decreases related to prior period positions		—		—		—
Unrecognized tax benefit--end of year	$	143	$	143	$	143

The Company files tax returns in the U.S. and various states. All tax years since inception (October 11, 2005) remain open to examination by major tax jurisdictions to which the Company is subject, as carryforward attributes generated in years past may still be adjusted upon examination by the Internal Revenue Service or state tax authorities if they have or will be used in a future period. The Company is currently not under examination by the Internal Revenue Service or any other jurisdictions for any tax years.

- Definition

The entire disclosure for income tax.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 942
-SubTopic 740
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147477617/942-740-50-1

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
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-Name Accounting Standards Codification
-Section S50
-Paragraph 1
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480738/235-10-S50-1

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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-Section 50
-Paragraph 1
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147478822/944-740-50-1

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482685/740-10-50-12

Reference 5: http://www.xbrl.org/2003/role/exampleRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 55
-Paragraph 231
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482663/740-10-55-231

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12C
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482685/740-10-50-12C

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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-SubTopic 270
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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-SubTopic 10
-Name Accounting Standards Codification
-Section S99
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Reference 10: http://www.xbrl.org/2003/role/disclosureRef
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Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org/1943274/2147480678/235-10-S99-1

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-Name Accounting Standards Codification
-Publisher FASB
-URI https://asc.fasb.org/740/tableOfContent

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
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-Section 50
-Paragraph 14
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482685/740-10-50-14

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
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-Name Accounting Standards Codification
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482685/740-10-50-21

Reference 15: http://www.xbrl.org/2003/role/disclosureRef
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-Section 50
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-Subparagraph (b)
-Publisher FASB
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-Paragraph 2
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-Section 50
-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482603/740-30-50-2

+ Details

Income Taxes - Schedule of Reconciliation of Provision for Income Taxes Computed at Statutory Federal Income Tax Rate to Provision for Income Taxes (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Income tax computed at federal statutory rate	$ (59,830)
State taxes, net of federal benefit	342
Tax Credits Research and development	2,529
Orphan drug	(26,991)
Nontaxable or Nondeductible items Stock option deduction	3,060
Nontaxable or Nondeductible items officer compensation	3,234
Nontaxable or Nondeductible items Other	202
Other Adjustments Other	363
Change in valuation allowance	77,524
Effective tax rate	$ 433
Income tax computed at federal statutory rate	21.00%	21.00%	21.00%
State taxes, net of federal benefit	(0.10%)	(0.10%)	13.20%
Tax Credits Research and development	(0.90%)
Orphan drug	9.50%
General business credit carryovers		1.10%	1.50%
Nontaxable or Nondeductible items Stock option deduction	(1.10%)
Non-deductible expenses	(1.10%)	(1.00%)	(1.00%)
Nontaxable or Nondeductible items Other	(0.10%)
Other Adjustments Other	(0.10%)	0.00%	0.00%
Change in valuation allowance	(27.30%)	(17.30%)	(34.90%)
Return to provision true up		(3.80%)	0.00%
Effective income tax rate	(0.20%)	(0.10%)	(0.20%)

Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Thousands	1 Months Ended
	Sep. 30, 2021	Dec. 31, 2025	Dec. 31, 2024	Apr. 30, 2013
Commitment And Contingencies [Line Items]
Contingent liabilities		$ 0	$ 0
Eddingpharm Purchase Agreement [Member]
Commitment And Contingencies [Line Items]
Purchase agreement obligation				$ 5,000
Incyte Agreement [Member] \| Global and U.S. [Member]
Commitment And Contingencies [Line Items]
Development costs associated with clinical trials	45.00%

Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Payables and Accruals [Abstract]
Product revenue allowances	$ 9,810	$ 849
Accrued clinical study and trial costs	18,977	23,869
Accrued selling, general, and administrative costs	6,316	4,258
Accrued compensation and related costs	24,352	14,477
Accrued professional fees	0	385
Accrued milestone costs	10,000	10,600
Accrued royalty payable	7,372	307
Accrued interest - debt	25,516	4,930
Other	721	421
Total accrued expenses and other current liabilities	$ 103,064	$ 60,096

Common Stock

12 Months Ended

Dec. 31, 2025

Equity [Abstract]

Common Stock

14. Common Stock

The Company is authorized to issue 200,000,000 shares of common stock. The holders of each share of common stock are entitled to one vote per share held and are entitled to receive dividends, if and when declared by

the Board, and to share ratably in the Company’s assets available for distribution to stockholders, in the event of liquidation.

In May 2023, the Company entered into a sales agreement with TD Cowen under which the Company could, from time to time, issue and sell shares of its common stock having aggregate sales proceeds of up to $200.0 million, in a series of one or more ATM equity offerings, or the 2023 ATM Program. TD Cowen is not required to sell any specific share amounts but acts as the Company’s sales agent, using commercially reasonable efforts consistent with its normal trading and sales practices. Pursuant to the new sales agreement, shares will be sold pursuant to the previous shelf registration statement on Form S-3ASR (Registration No. 333-254661), which became automatically effective upon filing on March 24, 2021. The Company’s common stock will be sold at prevailing market prices at the time of the sale, and as a result, prices may vary. In the year ended December 31, 2023, the Company sold 2,719,744 common shares of common stock under the 2023 ATM Program, with net proceeds of approximately $42.1 million.

In December 2021, the Company issued 3,802,144 shares of common stock and pre-funded warrants to purchase 1,142,856 shares of common stock. The offering price for the securities was $17.50 per share or $17.4999 for each Pre-Funded Warrant, with net proceeds of approximately $81.2 million. On January 24, 2023, 86,000 pre-funded warrants were exercised for 85,998 shares of common stock, under a cashless exercise. On April 12, 2023, 273,000 pre-funded warrants were exercised for 272,996 shares of common stock, under a cashless exercise. On May 9, 2023, 498,142 pre-funded warrants were exercised for 498,137 shares of common stock, under a cashless exercise. As of December 31, 2025, 285,714 pre-funded warrants were considered issued and outstanding.

In December 2023, the Company issued 12,432,431 shares of common stock. The offering price for the securities was $18.50 per share, with gross proceeds of approximately $230.0 million, offset by $14.0 million of issuance cost.

The Company has reserved for future issuance the following shares of common stock pursuant to the following outstanding securities or equity plans:


	December 31, 2025
Common stock issuable under pre-funded warrants		285,714
At-the-market program		7,280,256
RSUs and Options to purchase common stock		15,745,868
Equity plans		5,021,284
2015 Employee Stock Purchase Plan (the “ESPP”)		2,002,859
Total		30,335,981

Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Direct Placement Offering [Member]	Common Stock [Member]	Common Stock [Member] Direct Placement Offering [Member]	Additional Paid-In Capital [Member]	Additional Paid-In Capital [Member] Direct Placement Offering [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Deficit [Member]
Beginning balance at Dec. 31, 2022	$ 467,449		$ 7		$ 1,161,288		$ (806)	$ (693,040)
Beginning balance, Shares at Dec. 31, 2022			68,111,385
Proceeds from "at-the-market" offering, net, Value	42,139				42,139
Proceeds from "at-the-market" offering, net, Shares			2,719,744
Proceeds from direct offering, net, value		$ 215,955		$ 1		$ 215,954
Proceeds from direct offering,net, Shares				12,432,431
Stock purchase under ESPP, Shares			34,797
Pre-funded warrant cashless exercise, shares			857,131
Stock-based compensation expense	30,951				30,951
Unrealized (gain) loss on investments	1,024						1,024
Vesting of RSU, Shares			9,102
Employee withholdings ESPP	910				910
Proceeds from exercise of stock options	$ 5,128				5,128
Proceeds from exercise of stock options, Shares	662,042		662,042
Net Income (Loss)	$ (209,360)							(209,360)
Ending balance at Dec. 31, 2023	554,196		$ 8		1,456,370		218	(902,400)
Ending balance, Shares at Dec. 31, 2023			84,826,632
Stock purchase under ESPP, Shares			64,903
Stock-based compensation expense	43,026				43,026
Unrealized (gain) loss on investments	(55)						(55)
Vesting of RSU, Shares			85,495
Employee withholdings ESPP	1,715				1,715
Proceeds from exercise of stock options	$ 8,000		$ 1		7,999
Proceeds from exercise of stock options, Shares	717,413		717,413
Net Income (Loss)	$ (318,758)							(318,758)
Ending balance at Dec. 31, 2024	288,124		$ 9		1,509,110		163	(1,221,158)
Ending balance, Shares at Dec. 31, 2024			85,694,443
Stock purchase under ESPP, Shares			164,852
Stock-based compensation expense	47,963				47,963
Unrealized (gain) loss on investments	289						289
Vesting of RSU, Shares			410,707
Employee withholdings ESPP	1,538				1,538
Proceeds from exercise of stock options	$ 12,138				12,138
Proceeds from exercise of stock options, Shares	1,135,977		1,135,977
Net Income (Loss)	$ (285,422)							(285,422)
Ending balance at Dec. 31, 2025	$ 64,630		$ 9		$ 1,570,749		$ 452	$ (1,506,580)
Ending balance, Shares at Dec. 31, 2025			87,405,979

Inventory, net (Additional Information) (Details) $ in Millions	Dec. 31, 2025 USD ($)
Inventory, Net [Abstract]
Inventory Valuation Reserves	$ 0.2

Leases (Tables)

12 Months Ended

Dec. 31, 2025

Lessee Disclosure [Abstract]

Summary of Future Minimum Lease Payments under Operating Leases

Future minimum lease payments under the Company’s operating leases, were as follows:


Maturity of lease liabilities	As of
(in thousands)	December 31, 2025
2026		656
2027		676
2028		403
Thereafter		—
Total lease payments	$	1,735
Less: imputed interest		(214	)
Total operating lease liability	$	1,521

Fair Value Measurements - Schedule of Fair Values of Financial Assets and Liabilities Measured at Fair Value (Detail) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Short-term investments	$ 259,140	$ 418,801
Long-term investments	0	119,520
Carrying Value [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Cash equivalents	115,358	154,083
Short-term investments	259,140	418,801
Long-term investments	0	119,520
Total assets	374,498	692,404
Quoted Prices in Active Markets Level 1 [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Cash equivalents	115,358	129,187
Total assets	115,358	129,187
Significant Other Observable Inputs Level 2 [Member]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Cash equivalents		24,896
Short-term investments	259,140	418,801
Long-term investments	0	119,520
Total assets	$ 259,140	$ 563,217

Document and Entity Information - USD ($) $ in Millions	12 Months Ended
Document and Entity Information - USD ($) $ in Millions	Dec. 31, 2025	Feb. 23, 2026	Jun. 30, 2025
Cover [Abstract]
Document Type	10-K
Amendment Flag	false
Document Period End Date	Dec. 31, 2025
Document Fiscal Year Focus	2025
Document Fiscal Period Focus	FY
Trading Symbol	SNDX
Entity Registrant Name	Syndax Pharmaceuticals, Inc.
Entity Central Index Key	0001395937
Current Fiscal Year End Date	--12-31
Entity Filer Category	Large Accelerated Filer
Entity Small Business	false
Entity Emerging Growth Company	false
Title of 12(b) Security	Common Stock
Entity Common Stock, Shares Outstanding		88,200,596
Entity Current Reporting Status	Yes
Entity Shell Company	false
Entity File Number	001-37708
Entity Tax Identification Number	32-0162505
Entity Address, Address Line One	730 Third Avenue
Entity Address, Address Line Two	9th Floor
Entity Address, City or Town	New York
Entity Address, State or Province	NY
Entity Address, Postal Zip Code	10017
City Area Code	781
Local Phone Number	419-1400
Entity Interactive Data Current	Yes
Entity Incorporation, State or Country Code	DE
Document Annual Report	true
Document Transition Report	false
Security Exchange Name	NASDAQ
Entity Voluntary Filers	No
Entity Well-known Seasoned Issuer	Yes
ICFR Auditor Attestation Flag	true
Document Financial Statement Error Correction [Flag]	false
Entity Public Float			$ 799.2
Auditor Name	Deloitte & Touche LLP
Auditor Location	New York, New York
Auditor Firm ID	34
Auditor Opinion	We have audited the internal control over financial reporting of Syndax Pharmaceuticals, Inc. and subsidiaries (the “Company”) as of December 31, 2025, based on criteria established in Internal Control — Integrated Framework (2013) issued by the Committee of Sponsoring Organizations of the Treadway Commission (COSO). In our opinion, the Company maintained, in all material respects, effective internal control over financial reporting as of December 31, 2025, based on criteria established in Internal Control — Integrated Framework (2013) issued by COSO. We have also audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (PCAOB), the consolidated financial statements as of and for the year ended December 31, 2025, of the Company and our report dated February 26, 2026, expressed an unqualified opinion on those financial statements.
Documents Incorporated by Reference	DOCUMENTS INCORPORATED BY REFERENCE Portions of the registrant’s definitive proxy statement for its 2025 Annual Meeting of Stockholders, which the registrant intends to file pursuant to Regulation 14A with the Securities and Exchange Commission not later than 120 days after the registrant’s fiscal year ended December 31, 2025, are incorporated by reference into Part III of this Annual Report on Form 10-K.

Pay vs Performance Disclosure - USD ($) $ in Thousands	12 Months Ended
Pay vs Performance Disclosure - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Pay vs Performance Disclosure
Net Income (Loss)	$ (285,422)	$ (318,758)	$ (209,360)

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

+ Details

Prepaid Expenses and Other Current Assets

12 Months Ended

Dec. 31, 2025

Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]

Prepaid Expenses and Other Current Assets

12. Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consisted of the following (in thousands):


	December 31,
	2025		2024
Prepaid insurance	$	1,590	$	1,276
Interest receivable on investments		2,146		2,634
Prepaid subscriptions		2,221		1,605
Prepaid state and local taxes		13		298
Prepaid rent		55		107
Prepaid inventory		6,252		2,009
Other		1,219		612
Total prepaid expenses and other current assets	$	13,496	$	8,541